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Paralyzed rats exhibited a greater percentage of burst\u2010firing cells (69%) than did anesthetized animals (37%). Furthermore, paralyzed rats were less sensitive to the mixed D1\/D2 DA receptor agonist apomorphine and the selective D2 DA receptor agonist quinpirole. However, significantly higher doses of d\u2010amphetamine were required in paralyzed animals only with respect to inhibiting MADA neurons. The abilities of apomorphine and quinpirole to inhibit NSDA cell firing were rate\u2010dependent in both anesthetized and paralyzed rats, whereas d\u2010amphetamine\u2010induced inhibition was rate dependent only in anesthetized animals. In contrast, apomorphine\u2010 and quinpirole\u2010induced inhibition of MADA neurons were rate\u2010dependent only in anesthetized rats, whereas d\u2010amphetamine\u2010induced inhibition was rate\u2010dependent only in paralyzed animals. These results suggest that general anesthesia exerts subtle effects on the basal activity and pharmacological responsiveness of midbrain dopamine neurons.<\/jats:p>","DOI":"10.1002\/syn.890030105","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T15:33:09Z","timestamp":1104593589000},"page":"30-37","source":"Crossref","is-referenced-by-count":70,"title":["Chloral hydrate anesthesia alters the responsiveness of identified midbrain dopamine neurons to dopamine agonist administration"],"prefix":"10.1002","volume":"3","author":[{"given":"Mark D.","family":"Kelland","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arthur S.","family":"Freeman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Louis A.","family":"Chiodo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,10,12]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(69)90172-1"},{"key":"e_1_2_1_3_1","first-page":"244","article-title":"Anesthesia and the responsiveness of individual neurons of the caudate nucleus of the cat to acetylcholine, norepinephrine and dopamine administered by microelectrophoresis","volume":"15","author":"Bloom F. 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