{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T09:30:47Z","timestamp":1762075847574},"reference-count":38,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2004,10,12]],"date-time":"2004-10-12T00:00:00Z","timestamp":1097539200000},"content-version":"vor","delay-in-days":5763,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Synapse"],"published-print":{"date-parts":[[1989,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The effects of chronic blockade of D\u20101, D\u20102, or both subtypes of dopamine receptors on the densities and properties of the D\u20101 and D\u20102 subtypes of dopamine receptors were measured in rat brain. Animals were treated with 14 daily injections (i.p.) of the D\u20101\u2010selective antagonist SCH\u201023390, the D\u20102\u2010selective antagonist sulpiride, the nonselective antagonist fluphenazine, or vehicle. Serial 32\u2010\u03bcm horizontal sections that included the caudate putamen were cut and alternately assigned to assays for D\u20101 or D\u20102 receptors. D\u20101 receptors were labeled with <jats:sup>3<\/jats:sup>H\u2010SKF\u201083566 or <jats:sup>3<\/jats:sup>H\u2010SCH\u201023390, and D\u20102 receptors were labeled with <jats:sup>3<\/jats:sup>H\u2010spiroperidol. Scatchard analysis was performed on the saturation data measured in the head of the caudate putamen to obtain estimates of receptor density. As expected, administration of the D\u20101\u2010selective ligand SCH\u201023390 resulted in an increase in the density of D\u20101 receptors by approximately 47% and had no significant effect on the density of D\u20102 receptors. Similarly, administration of the D\u20102\u2010selective ligand sulpiride resulted in an increase in the density of D\u20102 receptors by 25% and had no significant effect on the density of D\u20101 receptors. Thus the subtypes of dopamine receptors appear to be independently regulated after selective blockade. In contrast to the effects observed with selective antagonists, the results obtained with fluphenazine were more complex. Administration of the relatively nonselective antagonist fluphenazine resulted in an increase in the density of D\u20102 receptors by 51% but had no significant effect on the density of D\u20101 receptors. One explanation for this result is that up\u2010regulation of D\u20102 receptors inhibits the regulation of D\u20101 receptors, suggesting that the regulation of subtypes of dopamine receptors is not entirely independent. In support of this hypothesis, coadministration of sulpiride with SCH\u201023390 attenuated the ability of SCH\u201023390 to up\u2010regulate D\u20101 receptors. To determine whether this phenomenon is observed in other brain regions, a second group of animals was chronically treated with selective and nonselective antagonists as described above, and coronal sections were cut at multiple levels of the brain. Receptors were labeled with a single concentration of either <jats:sup>3<\/jats:sup>H\u2010SCH\u201023390 or <jats:sup>3<\/jats:sup>H\u2010spiroperidol, and the binding of the radioligands in 19 discrete brain regions was measured. The effects of these treatments on D\u20101 and D\u20102 receptors in most of these regions were similar to those described above for the caudate putamen.<\/jats:p>","DOI":"10.1002\/syn.890030111","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T15:33:09Z","timestamp":1104593589000},"page":"74-82","source":"Crossref","is-referenced-by-count":44,"title":["Effects of chronic treatment with selective and nonselective antagonists on the subtypes of dopamine receptors"],"prefix":"10.1002","volume":"3","author":[{"given":"Paul","family":"McGonigle","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sally J.","family":"Boyson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susan","family":"Reuter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Perry B.","family":"Molinoff","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,10,12]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(85)90345-0"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0024-3205(84)90540-X"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.06-11-03177.1986"},{"key":"e_1_2_1_5_1","first-page":"193","article-title":"Quantitative autoradiography of D1 and D2 receptors following administration of neuroleptics","volume":"12","author":"Boyson S. 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