{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,23]],"date-time":"2023-10-23T06:23:21Z","timestamp":1698042201874},"reference-count":38,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2004,10,12]],"date-time":"2004-10-12T00:00:00Z","timestamp":1097539200000},"content-version":"vor","delay-in-days":5763,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Synapse"],"published-print":{"date-parts":[[1989,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In superfused rat hypothalamic slices prelabeled with [<jats:sup>3<\/jats:sup>H]\u20105\u2010hydroxytryptamine ([<jats:sup>3<\/jats:sup>H]\u20105\u2010HT), the 5\u2010HT autoreceptor agonists 5\u2010methoxytryptamine and RU 24969 inhibited in a concentration\u2010dependent manner the electrically evoked release of [<jats:sup>3<\/jats:sup>H]\u20105\u2010HT. Exposure to phorbol\u201012,13\u2010dibutyrate increased in a concentration\u2010dependent manner the stimulation\u2010evoked overflow of [<jats:sup>3<\/jats:sup>H]\u20105\u2010HT and shifted to the right the 5\u2010methoxytryptamine inhibition curve. Exposure to forskolin, a potent activator of adenylate cyclase, increased the stimulation\u2010evoked [<jats:sup>3<\/jats:sup>H]\u20105\u2010HT overflow and shifted to the left the 5\u2010methoxytryptamine or RU 24969 inhibitory curves on transmitter release. A similar interaction was observed in the presence of 1\u2010isobutyl,3\u2010methylxanthine (IBMX), a phosphodiesterase inhibitor, or 8\u2010bromo\u2010cyclic AMP and the serotonin autoreceptor agonist 5\u2010methoxytryptamine. In the presence of phorbol\u201012,13\u2010dibutyrate or forskolin, the enhancing effect of the 5\u2010HT autoreceptor antagonist methiothepin on the stimulation\u2010evoked [<jats:sup>3<\/jats:sup>H]\u20105\u2010HT overflow was significantly less pronounced than in the absence of these compounds. These results indicate that the presynaptic 5\u2010HT autoreceptors that modulate the release of [<jats:sup>3<\/jats:sup>H]\u20105\u2010HT in rat hypothalamic slices may be coupled to the phosphoinositide cycle and protein kinase C\u2010dependent mechanisms. In addition, the increase in intracellular level of cyclic AMP by forskolin, IBMX, and 8\u2010bromo\u2010cyclic AMP potentiates the inhibitory effects of the autoreceptor agonist 5\u2010methoxytryptamine on [<jats:sup>3<\/jats:sup>H]\u20105\u2010HT release, although the mechanism of the interaction remains to be elucidated.<\/jats:p>","DOI":"10.1002\/syn.890030302","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T15:34:34Z","timestamp":1104593674000},"page":"173-181","source":"Crossref","is-referenced-by-count":11,"title":["Phorbol\u201012,13\u2010dibutyrate antagonizes while forskolin potentiates the presynaptic autoreceptor\u2010mediated inhibition of [<sup>3<\/sup>H]\u20105\u2010hydroxytryptamine release in rat hypothalamic slices"],"prefix":"10.1002","volume":"3","author":[{"given":"R.","family":"Ramdine","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.\u2010M.","family":"Galzin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. 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