{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T22:45:01Z","timestamp":1790981101179,"version":"4.1.0"},"reference-count":35,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2004,10,12]],"date-time":"2004-10-12T00:00:00Z","timestamp":1097539200000},"content-version":"vor","delay-in-days":5763,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Synapse"],"published-print":{"date-parts":[[1989,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Previously we reported that acetylcholine (ACh) and acetyl\u2010beta\u2010methacholine (MCh) modify responses of neurons in auditory cortex to individual frequencies. The purpose of this study was to determine whether muscarinic agonists produce frequency\u2010specific alterations or general changes in cellular responses. Frequency\u2010specific modifications would be evident in alterations of frequency receptive fields (FRF) that differed across frequencies while general effects would be seen as changes that were more or less the same over frequencies. Responses of single neurons to designated sets of tones were recorded in the auditory cortex of chronically prepared awake cats before, during, and following ejection of ACh or MCh by iontophoresis or micropressure using multibarrel micropipettes. Frequency receptive fields were determined by presenting isointensity tones across a range of frequencies including the cell's best frequency (BF) to tone onset. FRF for \u201coff\u201d and \u201csustained (through)\u201d responses were also determined quantitatively. The effects of ACh and MCh were predominantly frequency\u2010specific (77%, 39\/51 cells); general changes (19%, 10\/51) and no effects (4%, 2\/51) were less likely. Frequency\u2010specific effects involved both facilitation and reduction of the same response component to different frequencies within the same neuron. For responses to tone onset (but not \u201cthrough\u201d and \u201coff\u201d responses), agonists were more likely to produce a decrease at the BF while simultaneously increasing responses to other frequencies. Agonists could increase or decrease frequency selectivity. Effects of agonists could be blocked by atropine, suggesting involvement of muscarinic receptors.<\/jats:p>","DOI":"10.1002\/syn.890040105","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T15:35:31Z","timestamp":1104593731000},"page":"30-43","source":"Crossref","is-referenced-by-count":117,"title":["Cholinergic modulation of frequency receptive fields in auditory cortex: I. Frequency\u2010specific effects of muscarinic agonists"],"prefix":"10.1002","volume":"4","author":[{"given":"Thomas M.","family":"McKenna","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John H.","family":"Ashe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norman M.","family":"Weinberger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,10,12]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6773(76)91108-1"},{"key":"e_1_2_1_3_1","doi-asserted-by":"crossref","unstructured":"Ashe J. H. McKenna T. M. andWeinberger N. M.(1989) Cholinergic modulation of frequency receptive fields in auditory cortex: II. Frequency specific effects of anticholinesterases provide evidence for a modulatory action of endogenous ACh.Synapse this issue.","DOI":"10.1002\/syn.890040106"},{"key":"e_1_2_1_4_1","first-page":"686","article-title":"Reflex response to clicks of cat's tensor tympani during sleep and wakefulness and the influence thereon of the auditory cortex","volume":"102","author":"Baust W.","year":"1964","journal-title":"Arch. Ital. Biol."},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(75)90157-2"},{"key":"e_1_2_1_6_1","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1152\/jn.1963.26.4.598","article-title":"Acoustical and nonacoustical factors modifying middle ear muscle activity in waking cats","volume":"26","author":"Carmel P. W.","year":"1963","journal-title":"J. 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