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The present study sought to relate these findings to endogenous actions of ACh by using the anticholinesterase agents eserine sulphate and soman (0\u20101,2,2\u2010trimethylpropylmethylphosphonofluoridate) to facilitate the effects of endogenous ACh. Frequency receptive fields (FRF) were determined by presenting sequences of different isointensity tones before, during, and after application of ACh, MCh, eserine, or soman; also the cholinesterase blockers were applied between applications of ACh or MCh. The major effects produced by the inhibitors were similar to those of the agonists. Predominant effects were frequency\u2010specific changes in FRF. Further, eserine and soman, similar to ACh and MCh, produced shifts in the best frequency (BF) of FRF due mainly to coordinated depression of responses to the BF and increased responses to adjacent, non\u2010BF. The results indicate that exogenous and endogenous ACh, acting via muscarinic receptors, can significantly influence the physiological functioning of cortical neurons and consequently their processing of sensory information.<\/jats:p>","DOI":"10.1002\/syn.890040106","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T15:35:31Z","timestamp":1104593731000},"page":"44-54","source":"Crossref","is-referenced-by-count":74,"title":["Cholinergic modulation of frequency receptive fields in auditory cortex: II. Frequency\u2010specific effects of anticholinesterases provide evidence for a modulatory action of endogenous Ach"],"prefix":"10.1002","volume":"4","author":[{"given":"John H.","family":"Ashe","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas M.","family":"McKenna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norman M.","family":"Weinberger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,10,12]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4684-5266-2_25"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0028-3908(84)90053-4"},{"key":"e_1_2_1_4_1","first-page":"862","article-title":"Learning specifically alters frequency receptive fields in auditory cortex","volume":"14","author":"Bakin J.","year":"1988","journal-title":"Soc. 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M.(1989) The role of context in the expression of learning\u2010induced plasticity of single neurons in auditory cortex.Behav. Neurosci.(in press).","DOI":"10.1037\/0735-7044.103.3.471"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(87)90407-0"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1121\/1.1910851"},{"key":"e_1_2_1_15_1","unstructured":"Hirschowitz B. L. Hammer R. Giachetti A. Keirns J. J. andLevine R. R.(1984) Proceeding of International Symposium on Subtypes of Muscarinic receptors.Trends in Pharmacol. 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