{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,23]],"date-time":"2023-10-23T12:43:42Z","timestamp":1698065022164},"reference-count":29,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2004,10,12]],"date-time":"2004-10-12T00:00:00Z","timestamp":1097539200000},"content-version":"vor","delay-in-days":5398,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Synapse"],"published-print":{"date-parts":[[1990,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In an effort to determine the degree to which the repeated administration of phenylp0ropanolamine (PPA) results in the development o tolerance to its disruptive effects on operant responding as wellas cross\u2010tolerance to the effets of autely administered amphetamine, water\u2010deprived rats were first trained on a fixed\u2010ratio 5 (FR\u20105) schedule for water presentation. Dose\u2010response curves for the effects of PPA and amphetamine (administered IP, 15 min presession) were then determined (ED<jats:sub>5<\/jats:sub> = 35.0 and 2.6 mg\/kg, respectively) followed by the chronic administration of 40.0 mg\/kg PPA (administered IP, 15 min prior to each session). When responding returned to pre hronic rates, the dose\u2010response curves wee redetermined for both PPA (ED<jats:sub>50<\/jats:sub>=220 mg\/kg) and amphetamine (ED<jats:sub>50<\/jats:sub>=48mg\/kg). In a second set of rats, trained under similar conditions, it was observed that pretreatment with alpha\u2010methyltyrosine (AMT, 100 mg\/kg IP, 2 h presession) antagonized the disruptive effets of both PPA and amphetamine, whereas pretreatment with reserpine (0.31 mg\/kg, IP, 12 h presession) antagonized the disruptive effects of PPA, but exacerbated the disruptive effects to amphetamine. In a separate experiment, the repeated administration of PPA 1 mg\/kg IP resulted in no long\u2010lasting depetions of atstriatal dopamine, serotonin, or 3,4\u2010dinhydroxphenylacetic acid (DOPAC) concentrations. These observations indicate that PPA and amphetamine share a similar mechanism of action to the degree that cross\u2010tolerance develops, but which isnonetheless dissociable with respect to their differential sensitivity to antagonists and their neurotoxic efficacy.<\/jats:p>","DOI":"10.1002\/syn.890060112","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T15:37:11Z","timestamp":1104593831000},"page":"101-105","source":"Crossref","is-referenced-by-count":1,"title":["Evalutation of the pharmacological similarities between phenlpopanolamine andamphetamine: Effects on schedule\u2010controlled behavior"],"prefix":"10.1002","volume":"6","author":[{"given":"George C.","family":"Wagner","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael F.","family":"Jarvis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,10,12]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.245.13.1346"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2042-7158.1984.tb04852.x"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00177562"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.245.6.601"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0195-6663(87)90051-1"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0024-3205(79)90147-4"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0091-3057(80)90216-6"},{"key":"e_1_2_1_9_1","first-page":"66","article-title":"The effects of morphine and nalorphine\u2010like drugs in the nondependent, morphine\u2010dependent and cyclazocine\u2010dependent chronic spinal dog","volume":"198","author":"Gilbert P. 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