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The content of 5\u2010HT, SP, and TRH in different parts of the spinal cord was determined by use of radioimmunoassay (RLA) (SP and TRH) and high\u2010performance liquid chromatography with electrochemical detection (HPLC\u2010ECD) (5\u2010HT).<\/jats:p><jats:p>For all three substances studied, immunoreactive (IR) axon terminals were found in all parts of the gray matter, but with clear regional variation in the density of innervation. Thus, all three substances showed a dense innervation in the motor nucleus, particularly in the ventral part of the nucles, while the superficial dorsal horn was very densely innervated by SP\u2010IR fibers (laminae I and II) and TRH\u2010IR fibers (laminae II and III). In the motor nucleus, the studied substances coexisted to a very high degree, but some 5\u2010HT\u2010IR fibers (about 10%) lacked peptide\u2010LI and some SP\u2010IR fibers (about10%) lacked peptide\u2010LI and some SP\u2010IR fibers (about10%) lacked 5\u2010HT\u2010LI while virtually all TRH\u2010IR fibers also contained 5\u2010HT\u2010LI. In the superficial dorsal horn (laminae I\u2010III), no coexistence was detected, while other parts of the gray matter displayed various degrees of coexistence in between those found in the motor nucleus and laminae I\u2010III.<\/jats:p><jats:p>The quantitative analyis of IR varicosities in the motor nucleus suggested that the unilateral L<jats:sub>7<\/jats:sub> motor nucleus is innerated by about 55\u2013110 \u00d7 10<jats:sup>6<\/jats:sup> 5\u2010HT\u2010IR nerve trminals, which may indicate as many as 4,000 boutons per descending 5\u2010HT cell body in the brain stem only with this restricted projection. When combining these results with the biochemical data, it could be calculated that the concentration of 5\u2010HT in IR varicosities is about 3\u20136 \u00d7 10<jats:sup>\u22123<\/jats:sup>M, while the corresponding figures for SP and TRH was 0.3\u20130.5 \u00d7 10<jats:sup>\u22123<\/jats:sup> M and 0.1\u20130.2 \u00d710<jats:sup>\u22123<\/jats:sup> M, respectively.<\/jats:p><jats:p>In cats subject to spinal cord transection at the lower thoracic level, all 5\u2010HT\u2010IR fibers in the L<jats:sub>7<\/jats:sub> segement had disapperared 44 days after the lesion, indicating a strict suprasegmental origion of 5\u2010HT\u2010IR fibers in this segment. A differential effect of the lesion was noticed, however, in that the dorsally projecting 5\u2010HT fibers without peptide\u2010LI had vanished already 74 days postoperatively, while a large part of the 5\u2010HT\u2010IR fibers to the motor nucleus with peptide\u2010LI still remained at this time interval. Furthermore, after the lesion increased numbers of SP\u2010IR cell bodies could be observed in the gray matter.<\/jats:p><jats:p>Combined spinal cord transection and unilateral dorsal rhizotomy caused a transient decrease of the dense SP\u2010IR plexus in laminae I and II on the rhizotomized side, whereas in this part of the cord CGRP\u2010LI completely disappeared.<\/jats:p><jats:p>It is concluded that the descending 5\u2010HT system constitutes a major innervation of the spinal cord and that it seems especially prominent in the motor nucleus, where it, in all probability, exerts direct effects on the motoneurons. The findings are discussed in relation to recent findings regarding possible functional implications of the 5\u2010HT pathway on spinal motoneurons in the cat.<\/jats:p>","DOI":"10.1002\/syn.890060305","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T15:39:10Z","timestamp":1104593950000},"page":"237-270","source":"Crossref","is-referenced-by-count":78,"title":["5\u2010Hydroxytryptamine, substance P, and thyrotropin\u2010releasing hormone in the adult cat spinal cord segment L<sub>7<\/sub>: Immunohistochemical and chemical studies"],"prefix":"10.1002","volume":"6","author":[{"given":"Ulf","family":"Arvidsson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Staffan","family":"Cullheim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brun","family":"Ulfhake","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geoffrey W.","family":"Bennett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin C. 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