{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T19:39:53Z","timestamp":1757705993351},"reference-count":48,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2004,10,12]],"date-time":"2004-10-12T00:00:00Z","timestamp":1097539200000},"content-version":"vor","delay-in-days":4821,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Synapse"],"published-print":{"date-parts":[[1991,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The density of [<jats:sup>125<\/jats:sup>I]iodo\u2010cyanopindolol binding to beta\u20101 and beta\u20102 adrenergic receptors was studied in post mortem basal ganglia samples of Huntington's chorea and Parkinson's disease patients using autoradiography. Whereas no significant changes were observed in sections from Parkinson's and Huntington's chorea grade 2 patients, a nearly complete loss of beta\u20101 binding sites was observed in the basal ganglia of Huntington patients at later stages of the disease. The concentration of beta\u20102 receptors was increased by a factor 2 in the posterior putamen of all choreic cases. These results are consistent with the view that beta\u20101 receptors are predominantly located on a subpopulation of neurons which degenerate at late stages of Huntington's chorea, while beta\u20102 receptors are present mainly on glial elements.<\/jats:p>","DOI":"10.1002\/syn.890080405","type":"journal-article","created":{"date-parts":[[2004,12,31]],"date-time":"2004-12-31T18:57:22Z","timestamp":1104519442000},"page":"270-280","source":"Crossref","is-referenced-by-count":33,"title":["Beta\u2010adrenergic receptor subtypes in the basal ganglia of patients with Huntington's chorea and Parkinson's disease"],"prefix":"10.1002","volume":"8","author":[{"given":"Christian","family":"Waeber","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monique","family":"Rigo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giorgia","family":"Chinaglia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alphonse","family":"Probst","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 M.","family":"Palacios","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,10,12]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/321168a0"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-510X(88)90173-6"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-510X(73)90175-5"},{"key":"e_1_2_1_5_2","first-page":"1183","article-title":"5\u2010HT1B receptors do occur in the human brain: autoradiographic and homogenate binding studies","volume":"13","author":"Biegon A.","year":"1987","journal-title":"Soc. Neurosci. Abst."},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.pa.20.040180.002533"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(84)90117-3"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(85)90444-3"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(86)91112-1"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(80)91162-2"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/263244a0"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410220207"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(89)90448-2"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197606102942402"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(76)90502-3"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1977.tb07733.x"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005072-198701000-00002"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(87)90694-9"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00325634"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/0166-2236(90)90104-I"},{"key":"e_1_2_1_21_2","first-page":"925","article-title":"Dopamine (3\u2010hydroxytyramime) and brain function","volume":"18","author":"Hornykiewicz O.","year":"1966","journal-title":"Pharmacol. Rev."},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(85)90657-0"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(86)90902-9"},{"key":"e_1_2_1_24_2","doi-asserted-by":"crossref","first-page":"2297","DOI":"10.1523\/JNEUROSCI.09-07-02297.1989","article-title":"Regulation of subtypes of \u03b2\u2010adrenergic receptors in rat brain following treatment with 6\u2010hydroxydopamine","volume":"9","author":"Johnson E. W.","year":"1989","journal-title":"J. Neurosci."},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-68029-8_5"},{"key":"e_1_2_1_26_2","doi-asserted-by":"publisher","DOI":"10.1002\/syn.890040305"},{"key":"e_1_2_1_27_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.ne.02.030179.000553"},{"key":"e_1_2_1_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(79)90226-7"},{"key":"e_1_2_1_29_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.ne.12.030189.000435"},{"key":"e_1_2_1_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/0197-0186(82)90036-5"},{"key":"e_1_2_1_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/0166-2236(86)90080-9"},{"key":"e_1_2_1_32_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01787120"},{"key":"e_1_2_1_33_2","first-page":"243","volume-title":"Progress in Brain Research","author":"Palacios J. M.","year":"1990"},{"key":"e_1_2_1_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(85)90977-1"},{"key":"e_1_2_1_35_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.52.2.201"},{"key":"e_1_2_1_36_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.81.5.1585"},{"key":"e_1_2_1_37_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.85.15.5733"},{"key":"e_1_2_1_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(79)90775-3"},{"key":"e_1_2_1_39_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.36.8.1067"},{"key":"e_1_2_1_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(83)90993-9"},{"key":"e_1_2_1_41_2","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902730304"},{"key":"e_1_2_1_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/0024-3205(83)90667-7"},{"key":"e_1_2_1_43_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005072-198511000-00003"},{"key":"e_1_2_1_44_2","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(89)90082-1"},{"key":"e_1_2_1_45_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00260602"},{"key":"e_1_2_1_46_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.34.9.1237"},{"key":"e_1_2_1_47_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(81)90502-5"},{"key":"e_1_2_1_48_2","volume-title":"Receptor binding studies in adrenergic pharmacology","author":"Williams L. T.","year":"1978"},{"key":"e_1_2_1_49_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(79)90720-0"}],"container-title":["Synapse"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fsyn.890080405","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/syn.890080405","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,23]],"date-time":"2023-10-23T01:02:22Z","timestamp":1698022942000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/syn.890080405"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1991,8]]},"references-count":48,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1991,8]]}},"alternative-id":["10.1002\/syn.890080405"],"URL":"https:\/\/doi.org\/10.1002\/syn.890080405","archive":["Portico"],"relation":{},"ISSN":["0887-4476","1098-2396"],"issn-type":[{"value":"0887-4476","type":"print"},{"value":"1098-2396","type":"electronic"}],"subject":[],"published":{"date-parts":[[1991,8]]}}}