{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,2]],"date-time":"2025-08-02T04:05:16Z","timestamp":1754107516136},"reference-count":29,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2004,10,12]],"date-time":"2004-10-12T00:00:00Z","timestamp":1097539200000},"content-version":"vor","delay-in-days":4699,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Synapse"],"published-print":{"date-parts":[[1991,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The effects of arylamine spider toxins on synaptic transmission in rat hippocampal slices were investigated. Two different responses were monitored: the AMPA receptor\u2010mediated population spike recorded in control buffer (selectively antagonized by DNQX) and the NMDA receptor\u2010mediated EPSP recorded in nominally magnesium\u2010free buffer containing 20 \u03bcM DNQX (selectively antagonized by AP5, AP7, and dizocilpine (MK\u2010801)). The synthetic arylamine spider toxins JSTX\u20103, argiotoxin\u2010636, and argiotoxin\u2010659 were 26 to 73 times more potent at antagonizing the NMDA receptor\u2010mediated EPSP (IC<jats:sub>50<\/jats:sub> values ranging from 12 to 24 \u03bcM) than the AMPA receptor\u2010mediated population spike (IC<jats:sub>50<\/jats:sub> values ranging from 612 to 878 \u03bcM). These results indicate that arylamine spider toxins are selective antagonists of NMDA receptors in the mammalian CNS.<\/jats:p>","DOI":"10.1002\/syn.890090403","type":"journal-article","created":{"date-parts":[[2004,12,31]],"date-time":"2004-12-31T20:26:59Z","timestamp":1104524819000},"page":"244-250","source":"Crossref","is-referenced-by-count":20,"title":["Arylamine spider toxins antagonize NMDA receptor\u2010mediated synaptic transmission in rat hippocampal slices"],"prefix":"10.1002","volume":"9","author":[{"given":"Alan L.","family":"Mueller","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benedict C.","family":"Albensi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alan H.","family":"Ganong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linda S.","family":"Reynolds","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hunter","family":"Jackson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,10,12]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(87)90453-8"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1989.sp017690"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(89)91587-4"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(88)90378-3"},{"key":"e_1_2_1_6_1","first-page":"143","article-title":"Excitatory amino acid receptors in the vertebrate central nervous system","volume":"40","author":"Collingridge G. 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