{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T03:13:24Z","timestamp":1761016404254},"reference-count":70,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2004,10,12]],"date-time":"2004-10-12T00:00:00Z","timestamp":1097539200000},"content-version":"vor","delay-in-days":4668,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Synapse"],"published-print":{"date-parts":[[1992,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Ligand binding to many transmitter receptors is much higher in layer Ia of rat posterior cingulate cortex than it is in other layer, and this is where most axons from the anterior thalamus terminate. The present study explores the possibility that a number of receptors may be expressed on axons from limbic thalamic nuclei that terminate in layer Ia. Unilateral thalamic lesions were placed in rats and, 2 weeks later, five ligand binding protocols, coverslip autoradiography, and single grain counting techniques were used to qunatify binding in control and ablated hemispheres. Binding to the following receptor subtypes was analyzed: M<jats:sub>2<\/jats:sub> acetylcholine, <jats:sup>3<\/jats:sup>H\u2010oxotremorine\u2010M, or <jats:sup>3<\/jats:sup>H\u2010AF\u2010DX 116 with 50 nM pirenzepine; serotonin<jats:sub>1B<\/jats:sub>, <jats:sup>125<\/jats:sup>I\u2010(\u2212)\u2010cyanopindolol with 30 \u03bcM isoproterenol; \u03b2<jats:sub>2<\/jats:sub>\u2010adrenoceptors, <jats:sup>125<\/jats:sup>I\u2010(\u2212)\u2010cyanopindolol with 1 \u03bcM serotonin and 10 \u03bcM atenolol; \u03bc\u2010opioid, <jats:sup>3<\/jats:sup>H\u2010Tyr\u2010D\u2010Ala\u2010Gly\u2010MePhe\u2010Gly\u2010ol; neurotensin, <jats:sup>3<\/jats:sup>H\u2010neurotensin. Thalamic lesions reduced binding in two laminar patterns. In one pattern, there was a major reduction in binding in most superficial layers with that in layer Ia ranging from 50 to 70% for binding to M<jats:sub>2<\/jats:sub> muscarinic and serotonin<jats:sub>1B<\/jats:sub> receptors. Binding to \u03b2<jats:sub>2<\/jats:sub>\u2010adrenoceptors was also reduced in most superficial layers but to a lesser extent. In the second pattern, reductions were limited to layer I with losses in layer Ia of 20\u201330% for \u03bc\u2010opioid and neurotensin receptors. In no instance was layer Ia binding completely abolished (i.e., postlesion peaks remained).<\/jats:p><jats:p>Since the transmitters for each of the five receptors analyzed in this study are not synthesized by anterior or laterodorsal thalamic neurons, these receptors are heteroreceptors. The greatest postlesion reduction in M<jats:sub>2<\/jats:sub> binding was for AF\u2010DX 116 and so most M<jats:sub>2<\/jats:sub> heteroreceptors are of the \u201ccardiac\u201d subtype. Finally, the diverse population of heteroreceptors on limbic thalamic axons provides for presynaptic modulation by a wide range of transmitter systems and suggests that thalamocortical transmission may not be a simple, unmodulated event.<\/jats:p>","DOI":"10.1002\/syn.890100107","type":"journal-article","created":{"date-parts":[[2004,12,31]],"date-time":"2004-12-31T20:25:13Z","timestamp":1104524713000},"page":"44-53","source":"Crossref","is-referenced-by-count":23,"title":["Multiple heteroreceptors on limbic thalamic axons: M<sub>2<\/sub> acetylcholine, serotonn<sub>1B<\/sub>, \u03b2<sub>2<\/sub>\u2010adrenoceptors, \u03bc\u2010opioid, and neurotensin"],"prefix":"10.1002","volume":"10","author":[{"given":"Brent A.","family":"Vogt","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter B.","family":"Crino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eugene L.","family":"Jensen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,10,12]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"335","volume-title":"Handbook of Chemical Neuroanatomy","author":"Abrams G. 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