{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T15:49:09Z","timestamp":1787500149781,"version":"build-2736575974"},"reference-count":58,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2004,10,12]],"date-time":"2004-10-12T00:00:00Z","timestamp":1097539200000},"content-version":"vor","delay-in-days":4608,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Synapse"],"published-print":{"date-parts":[[1992,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Serotonin (5HT) binding sites in autonomic portions of the dorsomedial medulla oblongata of the rat were localized using autoradiographic techniques with radioactive ligands that express high affinity for the 5HT\n                    <jats:sub>1<\/jats:sub>\n                    (\n                    <jats:sup>3<\/jats:sup>\n                    H\u20105HT), 5HT\n                    <jats:sub>1A<\/jats:sub>\n                    (\n                    <jats:sup>3<\/jats:sup>\n                    H\u20108OH\u2010DPAT), or 5HT\n                    <jats:sub>1B<\/jats:sub>\n                    (\n                    <jats:sup>125<\/jats:sup>\n                    I\u2010CYP with isoproterenol) receptor subtypes. 5HT\n                    <jats:sub>1A<\/jats:sub>\n                    sites were densely distributed in the nucleus tractus solitarius (NTS), with the highest densities localized to the interstitial subnucleus and the central subnucleus. 5HT\n                    <jats:sub>1B<\/jats:sub>\n                    sites were also found in the NTS, with the highest densities localized to the substantia gelatinosa subnucleus. The dorsal motor nucleus of the vagus nerve and nucleus ambiguus exhibited low densities of 5HT\n                    <jats:sub>1B<\/jats:sub>\n                    sites. However, the nucleus intercalatus, a cerebellar relay nucleus that also contains dendrites of vagal parasympathetic preganglionic neurons and receives autonomic forebrain afferent input, showed very dense 5HT\n                    <jats:sub>1B<\/jats:sub>\n                    sites. The promontorium, paratrigeminal islands, and the dorsomedial portion of the trigeminal nucleus (DM5), which are areas of viscerosomatic integration, exhibited high densities of both 5HT\n                    <jats:sub>1A<\/jats:sub>\n                    and 5HT\n                    <jats:sub>1B<\/jats:sub>\n                    sites. The area postrema contained low levels of both 5HT\n                    <jats:sub>1A<\/jats:sub>\n                    and 5HT\n                    <jats:sub>1B<\/jats:sub>\n                    sites.\n                  <\/jats:p>\n                  <jats:p>\n                    Visceral deafferentation via cervical vagotomy or nodose ganglionectomy caused a significant decrease in 5HT\n                    <jats:sub>1A<\/jats:sub>\n                    sites in the interstitial subnucleus of the NTS ipsilateral to the lesion. No changes were seen in 5HT\n                    <jats:sub>1B<\/jats:sub>\n                    sites.\n                  <\/jats:p>\n                  <jats:p>\n                    These studies suggest that 5HT\n                    <jats:sub>1A<\/jats:sub>\n                    and 5HT\n                    <jats:sub>1B<\/jats:sub>\n                    sites are involved in the processing of visceral sensory information in the NTS and associated areas. Based upon viscerotopic organization of the NTS, 5HT\n                    <jats:sub>1A<\/jats:sub>\n                    sites appear preferentially distributed in portions of the NTS that are associated with the coordination of swallowing, respiration, and cardiovascular function, while 5HT\n                    <jats:sub>1B<\/jats:sub>\n                    sites appear preferentially distributed in areas of the NTS associated with gastrointestinal, hepatic, pancreatic, and cardiovascular function. However, since these associations were not absolute and there was a great deal of overlap between the two sites, speculation regarding their specific functions in autonomic control must await pharmacological examination.\n                  <\/jats:p>","DOI":"10.1002\/syn.890100305","type":"journal-article","created":{"date-parts":[[2004,12,31]],"date-time":"2004-12-31T15:28:31Z","timestamp":1104506911000},"page":"217-227","source":"Crossref","is-referenced-by-count":57,"title":["Autoradiographic localization of 5HT\n                    <sub>1<\/sub>\n                    binding sites in autonomic areas of the rat dorsomedial medulla oblongata"],"prefix":"10.1002","volume":"10","author":[{"given":"Karl B.","family":"Thor","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alisa","family":"Blitz\u2010Siebert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cinda J.","family":"Helke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,10,12]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902830207"},{"issue":"106","key":"e_1_2_1_3_1","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1111\/apha.1953.29.s106.209","article-title":"On the central course of afferent fibres in the trigeminal, facial, glossopharyngeal and vagal nerves and their nuclei in the mouse","volume":"29","author":"Astrom K. E.","year":"1953","journal-title":"Acta Physiol. Scand."},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00178966"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0028-3908(81)90099-X"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902620408"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902400205"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(86)90498-1"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(83)90482-2"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-1838(82)90003-0"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(87)90218-7"},{"key":"e_1_2_1_12_1","first-page":"H231","article-title":"Fastigial nucleus cardiovascular response and brain stem lesions in the beagle","volume":"250","author":"Dormer K. J.","year":"1986","journal-title":"Am. J. Physiol."},{"key":"e_1_2_1_13_1","first-page":"851","article-title":"Effect of activation of central nervous system serotonin 1A receptors on cardiorespiratory function","volume":"248","author":"Gillis R. A.","year":"1989","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(79)95336-9"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902390204"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902220408"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/0361-9230(87)90013-X"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(85)90017-5"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(86)90446-4"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(87)90174-0"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00239551"},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(87)90214-4"},{"key":"e_1_2_1_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901930210"},{"key":"e_1_2_1_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902110304"},{"key":"e_1_2_1_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(85)90665-X"},{"key":"e_1_2_1_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(86)90117-5"},{"key":"e_1_2_1_27_1","first-page":"591","article-title":"Cerebellar afferent projections from the vestibular nuclei in the cat: An experimental study with the method of retrograde axonal transport of horseradish peroxidase","volume":"31","author":"Kotchabhakdi N.","year":"1978","journal-title":"Brain Res."},{"key":"e_1_2_1_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(84)90336-6"},{"key":"e_1_2_1_29_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1986.sp016291"},{"key":"e_1_2_1_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/0361-9230(82)90025-9"},{"key":"e_1_2_1_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(81)90136-1"},{"key":"e_1_2_1_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.903010405"},{"key":"e_1_2_1_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00569364"},{"key":"e_1_2_1_34_1","first-page":"1152","article-title":"Effects of serotonin1 and serotonin2 receptor agonists and antagonists on blood pressure, heart rate and sympathetic nerve activity","volume":"242","author":"McCall R. B.","year":"1987","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"e_1_2_1_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902550310"},{"key":"e_1_2_1_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(77)90105-7"},{"key":"e_1_2_1_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(83)90840-5"},{"key":"e_1_2_1_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902010308"},{"key":"e_1_2_1_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902730206"},{"key":"e_1_2_1_40_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4612-4560-5_4"},{"key":"e_1_2_1_41_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.ne.11.030188.000401"},{"key":"e_1_2_1_42_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00236814"},{"key":"e_1_2_1_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-1838(85)90034-7"},{"key":"e_1_2_1_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/0028-3908(89)90012-9"},{"key":"e_1_2_1_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-1838(83)90044-9"},{"key":"e_1_2_1_46_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.02-10-01424.1982"},{"key":"e_1_2_1_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(84)90191-5"},{"key":"e_1_2_1_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(85)91515-X"},{"key":"e_1_2_1_49_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902380411"},{"issue":"5","key":"e_1_2_1_50_1","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.1523\/JNEUROSCI.06-05-01220.1986","article-title":"Opioid peptide immunoreactivity in spinal and trigeminal dorsal horn neurons projecting to the parabrachial nucleus in the rat","volume":"6","author":"Standaert D. G.","year":"1986","journal-title":"J. Neurosci."},{"key":"e_1_2_1_51_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902460411"},{"key":"e_1_2_1_52_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00237674"},{"key":"e_1_2_1_53_1","first-page":"371","article-title":"Experimental studies of the vermal cerebellar projections in the brain stem of the cat (fastigiobulbar tract)","volume":"90","author":"Thomas D. M.","year":"1957","journal-title":"J. Anat."},{"key":"e_1_2_1_54_1","doi-asserted-by":"publisher","DOI":"10.1002\/syn.890100303"},{"key":"e_1_2_1_55_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902650210"},{"key":"e_1_2_1_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-3806(90)90062-4"},{"key":"e_1_2_1_57_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902880206"},{"key":"e_1_2_1_58_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902240102"},{"key":"e_1_2_1_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(88)90825-4"}],"container-title":["Synapse"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fsyn.890100305","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/syn.890100305","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,23]],"date-time":"2023-10-23T16:40:03Z","timestamp":1698079203000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/syn.890100305"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1992,3]]},"references-count":58,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1992,3]]}},"alternative-id":["10.1002\/syn.890100305"],"URL":"https:\/\/doi.org\/10.1002\/syn.890100305","archive":["Portico"],"relation":{},"ISSN":["0887-4476","1098-2396"],"issn-type":[{"value":"0887-4476","type":"print"},{"value":"1098-2396","type":"electronic"}],"subject":[],"published":{"date-parts":[[1992,3]]}}}