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Each subject received 2 PET studies with [<jats:sup>11<\/jats:sup>C]cocaine (3\u201311 m\u0308g), one before and one during alcohol intoxication (1 g\/kg). Regions of interest included dthe brain (n= 3) and heart (n = 4). arterial plasma was assayed for unchanged cocaine and for labelaed cocaethylene, a metabolite of cocaine found in individuals usig cocaine and alcohol in combination (hearn et al., 1991a). Alcohol intoxication did not change uptake and clearance or the steady\u2010state distribution volume of [<jats:sup>11<\/jats:sup>C]cocaine in brain (striatum, thalamus, and cerebellum) or in heart. Moreover, labeled cocaethylene was not detedted in the 10 minute plasma sample. These results suggest that the acute dnhancement of behavior and toxicity associated with the combined use of cocaine and alcohol is not due to an alteration in cocaine's organ distribution or to cocaethylene formation but may be related to an additive effect resulting from the direct actaons of each of these drugs. Published 1992 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/syn.890120308","type":"journal-article","created":{"date-parts":[[2004,12,31]],"date-time":"2004-12-31T22:29:49Z","timestamp":1104532189000},"page":"228-235","source":"Crossref","is-referenced-by-count":22,"title":["Alcohol inoxication does not change [<sup>11<\/sup>C]cocaine pharmacokinetics in human brain and heart"],"prefix":"10.1002","volume":"12","author":[{"given":"J. S.","family":"Fowler","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N. 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