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There was severe depletion of [<jats:sup>3<\/jats:sup>H]\u2010mazindol binding to dopamine (DA) uptake sites in the caudate, putamen, and SNc. The loss of [<jats:sup>3<\/jats:sup>H]\u2010mazindol binding in the nucleus accumbens (NAc) and olfactory tubercle (OT) was less marked. [<jats:sup>3<\/jats:sup>H]\u2010mazindol binding in the body of caudate nucleus showed a small but significant recovery with increasing post\u2010lesion survival times.<\/jats:p><jats:p>The specific binding of [<jats:sup>3<\/jats:sup>H]\u2010SCH 23390 to D\u20101 DA receptor sites was increased after MPTP treatment in all subregions of both caudate and putamen but was unaltered in the NAc and OT. Substantia nigra pars reticulata (SNr), frontal cortex, and medial segment of globus pallidus (GPm) all demonstrated moderate levels of [<jats:sup>3<\/jats:sup>H]\u2010SCH 23390 binding in control animals, which were unaffected by MPTP treatment. Specific [<jats:sup>3<\/jats:sup>H]\u2010spiperone binding to D\u20102 DA receptor sites was not altered by MPTP treatment in the subregions of caudate\u2010putamen. Moderate levels of [<jats:sup>3<\/jats:sup>H]\u2010spiperone binding were observed in control animals in the NAc, OT, SNc, and the lateral segment of globus pallidus (GPl). [<jats:sup>3<\/jats:sup>H]\u2010spiperone binding in the SNc and OT was partially decreased in MPTP\u2010treated animals. The changes in specific [<jats:sup>3<\/jats:sup>H]\u2010spiperone and [<jats:sup>3<\/jats:sup>H]\u2010SCH 23390 binding induced by MPTP\u2010treatment did not alter with post\u2010lesion survival times.<\/jats:p><jats:p>These results demonstrate that MPTP treatment causes greater dopaminergic denervation of the caudate\u2010putamen than in NAc\/OT. This resulted in an increase in postsynaptic D\u20101 DA receptor sites in the caudate\u2010putamen but not in the NAc\/OT. Also, there appeared to be loss of presynaptic D\u20102 DA receptic sites in the SNc and OT. In the caudate\u2010putamen, the loss of presynaptic D\u20102 DA receptor sites may have masked postsynaptic D\u20102 DA receptor upregulation. \u00a9 1993 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/syn.890140212","type":"journal-article","created":{"date-parts":[[2004,12,31]],"date-time":"2004-12-31T22:17:19Z","timestamp":1104531439000},"page":"184-194","source":"Crossref","is-referenced-by-count":62,"title":["Alterations in striatal and extrastriatal D\u20101 and D\u20102 dopamine receptors in the MPTP\u2010treated common marmoset: An autoradiographic study"],"prefix":"10.1002","volume":"14","author":[{"given":"Kanna K.","family":"Gnanalingham","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lance A.","family":"Smith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. 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