{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T20:35:20Z","timestamp":1762374920174},"reference-count":45,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2004,10,12]],"date-time":"2004-10-12T00:00:00Z","timestamp":1097539200000},"content-version":"vor","delay-in-days":4029,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Synapse"],"published-print":{"date-parts":[[1993,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>[<jats:sup>11<\/jats:sup>C]WIN 35,428 was evaluated as a specific in vivo radioligand for the dopamine transporter site by PET scanning in nonhuman primates and humans. In studies with a baboon (Papio anubis), [<jats:sup>11<\/jats:sup>C]WIN 35,428 accumulated in brain regions containing dopamine transporters, i.e., the striata. This accumulation was Partially blocked by prior administration of (\u2212)cocaine (4 mg\/kg, i.v. ). Placement of a unilateral lesion of dopamine\u2010containing nerve terminals with MPTP resulted in a unilateral reduction in [<jats:sup>11<\/jats:sup>C]WIN 35,428 accumulation in the striatum on the side of the lesion. Imaging of D<jats:sub>2<\/jats:sub> dopamine receptors with [<jats:sup>11<\/jats:sup>C]NMSP in the same MPTP\u2010treated animals showed much less reduction in the postsynaptic D<jats:sub>2<\/jats:sub> dopamine receptors as compared to the much larger reduction in the dopamine transporters labeled with [<jats:sup>11<\/jats:sup>C]WIN 35,428.<\/jats:p><jats:p>A total of ten normal human volunteers (five males and five females) with ages ranging from 19 to 81 years were studied. The caudate\/cerebellar and putamen\/cerebellar ratios ranged from 4.4 to 5.7 90 min after injection of the tracer. Preliminary kinetic modeling with arterial plasma sampling resulted in an average binding potential (K<jats:sub>3<\/jats:sub>\/K<jats:sub>4<\/jats:sub>) of 4.98 in the caudate nucleus and 5.13 in putamen. To demonstrate in vivo blockade with dopamine reuptake inhibitors, two subjects received prior oral doses of 6 mg mazindol. Subject 5 had significant reductions of 29% in the caudate\/cerebellar ratio at 90 min, 35% in the putamen\/cerebellar ratio at 90 min, 45% in the caudate k<jats:sup>3<\/jats:sup>\/k<jats:sup>4<\/jats:sup> ratio from 6.7 to 3.7, and 46% in the putamen k<jats:sup>3<\/jats:sup>\/k<jats:sup>4<\/jats:sup> from 4.7 to 2.5. Subject 8 had significant reductions of 20% in both the caudate\/cerebellar ratio and the putamen\/cerebellar ratio at 90 min.<\/jats:p><jats:p>During the human PET studies, a number of neuropsychological tests and physiological measurements were performed. No significant changes were found after administration of the [<jats:sup>11<\/jats:sup>C]WIN 35,428 alone. Taken together, these data indicate that [<jats:sup>11<\/jats:sup>C]WIN 35,428 is a promising radioligand for future studies of neuropsychiatric disorders that involve the dopamine transporter site. \u00a9 1993 Wiley\u2010Liss, Inc.<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"#note1\" \/><jats:fn><jats:p>This article is a US government work and as such, is in the public domain in the United States of America.<\/jats:p><\/jats:fn>\n<\/jats:p>","DOI":"10.1002\/syn.890150205","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T13:27:08Z","timestamp":1104586028000},"page":"130-142","source":"Crossref","is-referenced-by-count":124,"title":["In vivo imaging of baboon and human dopamine transporters by positron emission tomography using [<sup>11<\/sup>C]WIN 35,428"],"prefix":"10.1002","volume":"15","author":[{"given":"Dean F.","family":"Wong","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Babington","family":"Yung","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert F.","family":"Dannals","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elias K.","family":"Shaya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hayden T.","family":"Ravert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catherine A.","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Boon","family":"Chan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Traci","family":"Folio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ursula","family":"Scheffel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George A.","family":"Ricaurte","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John L.","family":"Neumeyer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr.","given":"Henry N.","family":"Wagner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael J.","family":"Kuhar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,10,12]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0404.1987.tb03582.x"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(91)90137-F"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/syn.890120104"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410300213"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/syn.890060211"},{"key":"e_1_2_1_7_1","first-page":"289","article-title":"[123I]3\u00df\u2010carboxylic acid methyl ester (RTI\u201055), a unique cocaine receptor ligand for imaging the dopamine and serotonin transporters in vivo","volume":"1","author":"Carroll F. 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