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Pregnant Sprague\u2010Dawley rats were administered either saline or (\u2212)cocaine (15 mg\/kg, s.c., b.i.d.) from gestational day 13 to 20. Prenatal cocaine exposure did not alter litter size, gender number, or progeny birth weights. Functional alterations in serotonergic systems were determined in postnatal day (PD) 70 male progeny by measuring changes in 5\u2010HT mediated plasma hormones following a single 8 mg\/kg injection of the 5\u2010HT releaser p\u2010chloroamphetamine (PCA). Cocaine exposed male progeny exhibited significant reductions in adrenocorticotropic hormone (ACTH, \u221243%) and renin (\u221262%) responses to PCA. However, no alterations were observed in the corticosterone or prolactin response to PCA. In utero exposure to cocaine did not alter basal levels of ACTH, renin, corticosterone, or prolactin. There were no significant differences in the density of either hypothalamic or cortical 5\u2010HT uptake sites. Likewise, there were no significant differences in the densities of any of the 5\u2010HT<jats:sub>1<\/jats:sub> receptor subtypes or in the density of 5\u2010HT<jats:sub>2<\/jats:sub> receptors in cortex. These data, which provide the first demonstration of deficits in 5\u2010HT mediated neuroendocrine function in adult progeny following in utero exposure to cocaine, indicate long\u2010term functional alterations of brain 5\u2010HT systems. \u00a9 1993 Wiley\u2010Liss, INe.<\/jats:p>","DOI":"10.1002\/syn.890150208","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T13:27:08Z","timestamp":1104586028000},"page":"158-168","source":"Crossref","is-referenced-by-count":39,"title":["Prenatal cocaine produces deficits in serotonin mediated neuroendocrine responses in adult rat progeny: Evidence for long\u2010term functional alterations in brain serotonin pathways"],"prefix":"10.1002","volume":"15","author":[{"given":"Theresa M.","family":"Cabrera","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph M.","family":"Yracheta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qian","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew D.","family":"Levy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Louis D.","family":"Van De Kar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George","family":"Battaglia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,10,12]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(92)90450-N"},{"issue":"2","key":"e_1_2_1_3_1","first-page":"843","article-title":"Autoradiographic characterization of (\u00b1)DOI binding to 5\u2010HT2 and 5\u2010HT10 receptors in rat brain","volume":"255","author":"Appel N. 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