{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,27]],"date-time":"2023-10-27T15:22:18Z","timestamp":1698420138441},"reference-count":35,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2004,10,12]],"date-time":"2004-10-12T00:00:00Z","timestamp":1097539200000},"content-version":"vor","delay-in-days":3786,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Synapse"],"published-print":{"date-parts":[[1994,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Muscarinic agonists produce membrane depolarization and losses of spike frequency accommodation and the slow afterhyperpolarization (AHP) when applied to neurons of the basolateral amygdala (BLA). Underlying these changes are the muscarinic\u2010induced inhibitions of several K<jats:sup>+<\/jats:sup> conductances, including the voltage\u2010activated M\u2010current (I<jats:sub>M<\/jats:sub>), a slowly decaying Ca<jats:sup>2<\/jats:sup>\u2010activated current (I<jats:sub>AHP<\/jats:sub>), a voltage\u2010insensitive leak current (I<jats:sub>Leak<\/jats:sub>), and the hyperpolarization\u2010activated inward rectifier current (I<jats:sub>IR<\/jats:sub>) Similar depolarizations and losses of the slow AHP have been observed in other neuronal cell types following stimulation of metabotropic glutamate receptors. Therefore, we tested the effects of the metabotropic glutamate receptor agonist, 1\u2010aminocyclopentanels, 3r\u2010dicarboxylic acid (ACPD), on pyramidal neurons impaled with a single microelectrode for current\u2010 and voltage\u2010clamp recordings in a brain slice preparation of the rat BLA. Application of ACPD (20 or 100 \u03bcM) to BLA neurons inhibited I<jats:sub>M<\/jats:sub> and I<jats:sub>A HP<\/jats:sub>, resulting in membrane depolarization and reductions in the amplitude and duration of the slow AHP. However, ACPD did not inhibit the muscarinic\u2010sensitive current I<jats:sub>IR<\/jats:sub>, nor was I<jats:sub>Leak<\/jats:sub> blocked in the majority of neurons examined. These findings suggest the possibility that muscarinic cholinergic and metabotropic glutamatergic receptor agonists may activate separate intracellular transduction pathways which have convergent inhibitory effects onto I<jats:sub>M<\/jats:sub> and I<jats:sub>AHP<\/jats:sub> in BLA pyramidal neurons. \u00a9 1994 Wiley\u2010hiss, Inc.<\/jats:p>","DOI":"10.1002\/syn.890170202","type":"journal-article","created":{"date-parts":[[2004,12,31]],"date-time":"2004-12-31T22:20:11Z","timestamp":1104531611000},"page":"69-75","source":"Crossref","is-referenced-by-count":19,"title":["Metabotropic glutamate receptor agonist ACPD inhibits some, but not all, muscarinic\u2010sensitive K<sup>+<\/sup> conductances in basolateral amygdaloid neurons"],"prefix":"10.1002","volume":"17","author":[{"given":"Mark D.","family":"Womble","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hylan C.","family":"Moises","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,10,12]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"1299","article-title":"Long\u2010lasting enhancement of metabotropic excitatory amino acid receptor\u2010mediated' polyphosphoinositide hydrolysis in the amygdala\/pyriform cortex of deep prepiriforin cortical kindled rats. 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