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The highest densities were found in the choroid plexus, pituitary gland\u2010where IGF\u2010I receptors were mainly concentrated in the anterior lobe, pineal gland, glomerular layer of the olfactory bulb, and the molecular layer of the cerebellar cortex. Moderate densities were present in cerebral cortex, caudate nucleus, putamen, accumbens, the CA1, CA2, CA3 fields and dentate gyrus of the hippocampus, the dendate nucleus of the cerebellum, amygdala, thalamus, pontine nuclei, and substantia nigra. All other brain areas, including white matter, contained low densities of IGF\u2010I receptors. The finding that several well\u2010defined brain structures are enriched with IGF\u2010I receptors suggests a rieurotrophic\/survival or neuromodulatory role of insulin\u2010like growth factors on specific neuronal systems. 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