{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T11:55:33Z","timestamp":1759146933966},"reference-count":51,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2004,10,12]],"date-time":"2004-10-12T00:00:00Z","timestamp":1097539200000},"content-version":"vor","delay-in-days":3482,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Synapse"],"published-print":{"date-parts":[[1995,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In order to study the possible contribution of the substantia nigra (SN) in the positive interaction between dopamine D<jats:sub>1<\/jats:sub> receptor agonists and glutamate antagonists in unilaterally 6\u2010hydroxydopamine (6\u2010OHDA) lesioned rats, the effect of the D<jats:sub>1<\/jats:sub> agonist, SKF 38393, was studied in combination with intranigral infusions of glutamate antagonists of the NMDA (MK 801, CPP) or AMPA (NBQX) type of receptor. Local infusion into the SN of the 6\u2010OHDA lesioned side of MK 801, CPP or NBQX at doses inducing no or minimal behavioral effects significantly increased the turning behavior and the expression of c\u2010fos induced, in the lesioned caudate\u2010putamen (CPu), by a parenteral administration of SKF 38393. The same result was obtained after intra\u2010SN infusion of the GABA agonist, muscimol. High doses of MK 801, CPP or muscimol infused into the SN produced intense contralateral turning per se and induced a sparse c\u2010fos expression in the lesioned CPu which was antagonized by parenteral administration of MK 801. The results indicate that a depression of SN pars reticulata efferent neurons potentiates D<jats:sub>1<\/jats:sub>\u2010mediated responses and suggest that this area may play a role in the positive interaction between glutamate antagonists and D<jats:sub>1<\/jats:sub> receptor agonists. \u00a9 1995 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/syn.890190402","type":"journal-article","created":{"date-parts":[[2004,12,31]],"date-time":"2004-12-31T22:24:35Z","timestamp":1104531875000},"page":"233-240","source":"Crossref","is-referenced-by-count":17,"title":["Modulation of dopamine D<sub>1<\/sub>\u2010mediated turning behavior and striatal c\u2010fos expression by the substantia nigra"],"prefix":"10.1002","volume":"19","author":[{"given":"S.","family":"Fenu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Carta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Morelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,10,12]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(89)90103-0"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0166-2236(89)90074-X"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(92)90006-N"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.ne.09.030186.002041"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(89)90183-8"},{"key":"e_1_2_1_7_1","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1152\/jn.1992.68.3.767","article-title":"Dopamine and glutamate agonists stimulate neuron specific expression of fos\u2010like protein in the striatum","volume":"68","author":"Beretta S.","year":"1992","journal-title":"J. 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