{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T20:02:05Z","timestamp":1760644925942},"reference-count":19,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2004,10,12]],"date-time":"2004-10-12T00:00:00Z","timestamp":1097539200000},"content-version":"vor","delay-in-days":3482,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Synapse"],"published-print":{"date-parts":[[1995,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>I\u2010123 or C\u201011 labelled 2\u03b2\u2010carbomethoxy\u20103\u03b2\u2010(4\u2010iodophenyl)tropane (\u03b2\u2010CIT) is a recently developed radioligand for the study of dopamine and serotonin reuptake sites in humans with single photon emission tomography (SPET) or positron emission tomography (PET). Determination of the radioligand metabolite pattern is fundamental for a quantitative analysis of radioligand binding. The metabolism of [<jats:sup>123<\/jats:sup>I]\u03b2\u2010CIT was determined by a gradient HPLC method in plasma samples of six human subjects. Two metabolites of [<jats:sup>123<\/jats:sup>I]\u03b2\u2010CIT were found, a polar and a lipophilic. At 4 h after [<jats:sup>123<\/jats:sup>I]\u03b2\u2010CIT injection the percentages of parent compound and polar and lipophilic metabolites were 23 \u00b1 3% (mean \u00b1 SD), 33 \u00b1 11%, and 44 \u00b1 8%, respectively. The lipophilic metabolite might pass the blood\u2010brain barrier and account for a fraction of free and nonspecifically bound radioactivity in brain. The existence of a lipophilic metabolite of [<jats:sup>123<\/jats:sup>I]\u03b2\u2010CIT may obstruct the use of simple ratio methods for quantitation of the dopamine transporter in brain. \u00a9 1995 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/syn.890190407","type":"journal-article","created":{"date-parts":[[2004,12,31]],"date-time":"2004-12-31T22:24:35Z","timestamp":1104531875000},"page":"297-300","source":"Crossref","is-referenced-by-count":19,"title":["Lipophilic metabolite of [<sup>123<\/sup>I]\u03b2\u2010CIT in human plasma may obstruct quantitation of the dopamine transporter"],"prefix":"10.1002","volume":"19","author":[{"given":"Kim A.","family":"Bergstr\u00f6m","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christer","family":"Halldin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jyrki T.","family":"Kuikka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carl\u2010Gunnar","family":"Swahn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jari","family":"Tiihonen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jukka","family":"Hiltunen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Esko","family":"L\u00e4nsimies","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lars","family":"Farde","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,10,12]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0969-8051(93)90028-S"},{"key":"e_1_2_1_3_1","first-page":"S14","article-title":"Pharmacokinetics and biodistribution of [123I]\u03b2\u2010CIT in humans","volume":"21","author":"Bergstr\u00f6m K.","year":"1994","journal-title":"Eur. J. Nucl. Med."},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(91)90137-F"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01245007"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.2867601"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/syn.890160203"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.1994.62031154.x"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.1984.33"},{"key":"e_1_2_1_10_1","first-page":"871","article-title":"(S)\u2010 and (R)\u2010[11C]nicotine and the metabolite (R\/S)[11C]cotinine. Preparation, metabolite studies and in vivo distribution in the human brain using PET","volume":"19","author":"Halldin C.","year":"1992","journal-title":"Nucl. Med. Biol."},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.90.24.11965"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00180909"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/syn.890130402"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.1992.101"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/0969-8051(93)90045-V"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm00114a027"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.1983.1"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.1994.62020549.x"},{"key":"e_1_2_1_19_1","first-page":"284","article-title":"A rapid and efficient HPLC\u2010method for determination of ligand metabolism during PET\u2010studies\u2010exemplified with [11C]raclopride","volume":"32","author":"Swahn C.\u2010G.","year":"1993","journal-title":"J. Labelled Cmpd. Radiopharm."},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/hup.470090103"}],"container-title":["Synapse"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fsyn.890190407","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/syn.890190407","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,26]],"date-time":"2023-10-26T23:21:03Z","timestamp":1698362463000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/syn.890190407"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1995,4]]},"references-count":19,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1995,4]]}},"alternative-id":["10.1002\/syn.890190407"],"URL":"https:\/\/doi.org\/10.1002\/syn.890190407","archive":["Portico"],"relation":{},"ISSN":["0887-4476","1098-2396"],"issn-type":[{"value":"0887-4476","type":"print"},{"value":"1098-2396","type":"electronic"}],"subject":[],"published":{"date-parts":[[1995,4]]}}}