{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:56:35Z","timestamp":1786978595356,"version":"build-2736575974"},"reference-count":34,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2002,6,19]],"date-time":"2002-06-19T00:00:00Z","timestamp":1024444800000},"content-version":"vor","delay-in-days":169,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Teratog Carcinog Mutagen"],"published-print":{"date-parts":[[2002,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Effects of methionine, an essential amino acid, on the embryotoxicity of selenium (Se) were examined using the rat embryo culture. Rat embryos at day 9.5 of gestation were cultured for 48 h in the presence of sodium selenite at 10 and 20 \u03bcM or sodium selenate at 30 and 100 \u03bcM with or without the addition of 1 mM DL\u2010methionine. Selenite at 20 \u03bcM or selenate at 100 \u03bcM alone increased the incidence of embryonic malformation and inhibited the embryonic growth. The addition of methionine increased the incidence of embryonic malformation at 10 \u03bcM of selenite but decreased the incidence of embryonic malformation at 100 \u03bcM of selenate. On the other hand, the addition of methionine partially restored the inhibited embryonic growth at 20 \u03bcM of selenite or at 100 \u03bcM of selenate. It was considered from these results that the methionine availability in the embryonic environment and the oxidation state of Se are critical in Se embryotoxicity. \u00a9 2002 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/tcm.10025","type":"journal-article","created":{"date-parts":[[2002,10,6]],"date-time":"2002-10-06T08:43:37Z","timestamp":1033893817000},"page":"301-308","source":"Crossref","is-referenced-by-count":6,"title":["Effects of methionine on selenium embryotoxicity in cultured rat 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