{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T12:45:07Z","timestamp":1761741907080},"reference-count":17,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2001,4,6]],"date-time":"2001-04-06T00:00:00Z","timestamp":986515200000},"content-version":"vor","delay-in-days":95,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Teratog Carcinog Mutagen"],"published-print":{"date-parts":[[2001,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Oral administration of clomiphene at 2, 4, or 8 mg\/kg to 4\u2010day\u2010old rats caused multiple histopathological abnormalities of the reproductive tract in both male and female animals. No histopathological abnormalities were observed in 30\u2010day\u2010old male rats at any dose examined. In contrast, 30\u2010day\u2010old females showed hypertrophy of the myometrium at all doses examined, and hypertrophy of the luminal or glandular epithelium, and dilatation of the uterine lumen were observed in the highest dose group. In post\u2010pubertal rats, histopathologically marked changes were observed in the testes and epididymides in males, and in the ovaries and uterus in females in the highest dose group. In addition, relative weight of male reproductive organs in the highest dose group was decreased as compared with that in the controls. These results suggested that early neonatal exposure to clomiphene induced marked reproductive tract abnormalities in males after puberty, as well as in females. <jats:italic>Teratogenesis Carcinog. Mutagen. 21:213\u2013221, 2001.<\/jats:italic> \u00a9 2001 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/tcm.1010","type":"journal-article","created":{"date-parts":[[2002,8,25]],"date-time":"2002-08-25T20:21:39Z","timestamp":1030306899000},"page":"213-221","source":"Crossref","is-referenced-by-count":8,"title":["Oral administration of clomiphene to neonatal rats causes reproductive tract abnormalities"],"prefix":"10.1002","volume":"21","author":[{"given":"Tetsuji","family":"Nagao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sinsuke","family":"Yoshimura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2001,4,6]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"295","volume-title":"Hormones and cancer","author":"Clark JH","year":"1980"},{"key":"e_1_2_1_3_2","first-page":"103","volume-title":"Estrogens in the environment","author":"Martin L","year":"1980"},{"key":"e_1_2_1_4_2","first-page":"134","volume-title":"Ovulation, stimulation, suppression, detection","author":"Greenblatt RB","year":"1966"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.1.5741.152"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.877546"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-4731(80)90249-6"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.432668"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod21.5.1087"},{"key":"e_1_2_1_10_2","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/0002-9378(82)90221-6","article-title":"Heterotopic columnar epithelium and adenosis in the vagina of the mouse after neonatal treatment with clomiphene citrate","volume":"144","author":"Gorwill RH","year":"1982","journal-title":"Am J Obstet Gynecol"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-4731(83)90124-3"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(85)90163-2"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(87)80381-7"},{"key":"e_1_2_1_14_2","volume-title":"Principles and procedures of statistics","author":"Steel RGD","year":"1960"},{"key":"e_1_2_1_15_2","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/0002-9378(64)90489-2","article-title":"The production of ovarian dysgenesis in the rat by ethamoxytriphetol (MER\u201025)","volume":"90","author":"Heller RH","year":"1964","journal-title":"Am J Obstet Gynecol"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/0039-128X(73)90118-9"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/251446a0"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1741-4520.1999.tb00568.x"}],"container-title":["Teratogenesis, Carcinogenesis, and Mutagenesis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Ftcm.1010","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/tcm.1010","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,19]],"date-time":"2023-11-19T16:46:29Z","timestamp":1700412389000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/tcm.1010"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,1]]},"references-count":17,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2001,1]]}},"alternative-id":["10.1002\/tcm.1010"],"URL":"https:\/\/doi.org\/10.1002\/tcm.1010","archive":["Portico"],"relation":{},"ISSN":["0270-3211","1520-6866"],"issn-type":[{"value":"0270-3211","type":"print"},{"value":"1520-6866","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001,1]]}}}