{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T01:10:33Z","timestamp":1777425033339,"version":"3.51.4"},"reference-count":16,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2001,4,6]],"date-time":"2001-04-06T00:00:00Z","timestamp":986515200000},"content-version":"vor","delay-in-days":95,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Teratog Carcinog Mutagen"],"published-print":{"date-parts":[[2001,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Triterpenoid compounds, isolated from plants of <jats:italic>Abies<\/jats:italic> genus (Pinceae), are known to exert anti\u2010tumor promotion activities in mouse skin carcinogenesis. In the present study, we investigated whether AVB\u20101 and acid and acid methyl ester derivatives have inhibitory effects on rat hepatocarcinogenesis by using a liver medium\u2010term bioassay for carcinogens (Ito\u2019s test), immunohistochemically assessing the numbers and areas per cm<jats:sup>2<\/jats:sup> of preneoplastic lesions, glutathione <jats:italic>S<\/jats:italic>\u2010transferase placental form (GST\u2010P)\u2010positive foci. In experiment 1, 6\u2010week\u2010old male Fisher 344 rats were given a single intraperitoneal injection of diethylnitrosamine (200 mg\/kg b.w.) and subjected to two\u2010thirds partial hepatectomy at week 3. From weeks 2 to 8, the compounds were given three times a week at a dose of 1 mg\/kg b.w. by i.g. gavage and found to significantly decrease the number of GST\u2010P\u2010positive foci in the liver. In experiment 2, AVB\u20101 was given three times a week at doses of 3, 1, or 0.3 mg\/kg b.w. by i.g. gavage from weeks 2 to 8. All doses of AVB\u20101 significantly decreased the numbers of GST\u2010P\u2010positive foci. Thus, our results suggest that AVB\u20101 is a chemopreventive agent for rat hepatocarcinogenesis. <jats:italic>Teratogenesis Carcinog. Mutagen. 21:223\u2013229, 2001.<\/jats:italic> \u00a9 2001 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/tcm.1011","type":"journal-article","created":{"date-parts":[[2002,8,25]],"date-time":"2002-08-25T20:21:39Z","timestamp":1030306899000},"page":"223-229","source":"Crossref","is-referenced-by-count":4,"title":["Possible prevention by abieslactone of development of diethylnitrosamine\u2010initiated GST\u2010P positive foci in the rat liver"],"prefix":"10.1002","volume":"21","author":[{"given":"Shuji","family":"Iwai","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min","family":"Wei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keiichirou","family":"Morimura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideki","family":"Wanibuchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reiko","family":"Tanaka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shunyo","family":"Matsunaga","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akira","family":"Yoshitake","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuichi","family":"Seki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shoji","family":"Fukushima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2001,4,6]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.6351251"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.83.5.1490"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1021\/np50064a039"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1159\/000227592"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3835(95)03856-R"},{"key":"e_1_2_1_7_2","first-page":"5210","article-title":"Inhibition 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