{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,20]],"date-time":"2025-12-20T21:39:13Z","timestamp":1766266753423},"reference-count":20,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2005,9,9]],"date-time":"2005-09-09T00:00:00Z","timestamp":1126224000000},"content-version":"vor","delay-in-days":9017,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Teratog Carcinog Mutagen"],"published-print":{"date-parts":[[1981,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The frequency of x\u2010ray\u2010induced chromosome aberrations in G<jats:sub>0<\/jats:sub> human lymphocytes was greatly increased when cells were incubated with cytosine arabinoside (ara\u2010C) after irradiation. The frequency of dicentrics increased with increasing ara\u2010C incubation times (one, two, and three hours). Lymphocytes from Down syndrome individuals were more sensitive to aberration induction by x\u2010rays in G<jats:sub>0<\/jats:sub>, and the increase in dicentric frequency with ara\u2010C incubation was much more rapid than with normal cells. When G<jats:sub>2<\/jats:sub> normal lymphocytes were x\u2010irradiated and incubated for two or three hours with ara\u2010C until fixation, there was a large increase in deletion frequency compared to cells x\u2010irradiated and incubated in the absence of ara\u2010C. However, no exchanges were observed in the presence of ara\u2010C, compared to 0.29 per cell as when x\u2010rays alone were given. These results form the basis for a discussion of the mechanism of aberration induction by x\u2010rays.<\/jats:p><jats:p>Experiments with two chemicals, 4\u2010nitroquinoline\u2010N\u2010oxide and methyl methanesulfonate, show that chromosome\u2010type aberrations can be induced in G<jats:sub>1<\/jats:sub> treated lymphocytes incubated with ara\u2010C. However, these chemicals, in the absence of ara\u2010C incubation, induced no aberrations in G<jats:sub>1<\/jats:sub> at the concentrations used. The mechanism of aberration induction is discussed, particularly in terms of whether or not chemicals can be defined as S\u2010phase dependent.<\/jats:p>","DOI":"10.1002\/tcm.1770010204","type":"journal-article","created":{"date-parts":[[2006,2,4]],"date-time":"2006-02-04T13:26:31Z","timestamp":1139059591000},"page":"147-159","source":"Crossref","is-referenced-by-count":17,"title":["DNA repair and chromosome aberrations: The effect of cytosine arabinoside on the frequency of chromosome aberrations induced by radiation and chemicals"],"prefix":"10.1002","volume":"1","author":[{"given":"R. J.","family":"Preston","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,9,9]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0027-5107(74)90140-7"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0027-5107(71)90050-9"},{"key":"e_1_2_1_4_1","first-page":"52","article-title":"The repair of x\u2010ray\u2010induced chromosomal damage in trisomy 21 and normal diploid lymphocytes","volume":"37","author":"Countryman PI","year":"1977","journal-title":"Cancer Res"},{"key":"e_1_2_1_5_1","first-page":"57","volume-title":"Progress in Genetic Toxicology","author":"Evans HJ","year":"1977"},{"key":"e_1_2_1_6_1","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1093\/genetics\/49.1.17","article-title":"Influence of DNA synthesis on the production of chromatid aberrations by x\u2010rays and maleic hydrazide in Vicia faba","volume":"49","author":"Evans HJ","year":"1964","journal-title":"Genetics"},{"key":"e_1_2_1_7_1","first-page":"2636","article-title":"Studies in mouse L\u2010cells on the incorporation of 1\u2010\u03b2\u2010D\u2010arabinofuranosylcytosine with DNA and on inhibition of DNA polymerase by 1\u2010\u03b2\u2010D\u2010arabinofurano\u2010sylcytosine 5\u2032\u2010triphosphate","volume":"30","author":"Graham FL","year":"1970","journal-title":"Cancer Res"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.179.4068.86"},{"key":"e_1_2_1_9_1","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1182\/blood.V45.4.503.503","article-title":"Radiosensitivities of DNA molecules in lymphocytes from the circulating blood of man","volume":"45","author":"Hashimoto Y","year":"1975","journal-title":"Blood"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0005-2787(77)90238-6"},{"key":"e_1_2_1_11_1","volume-title":"Actions of Chemicals on Dividing Cells","author":"Kihlman BA","year":"1966"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi00717a011"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-1809.1956.tb01387.x"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/260444a0"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/0027-5107(80)90177-3"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/0027-5107(73)90202-9"},{"key":"e_1_2_1_17_1","first-page":"81","article-title":"Chromosomal radiosensitivity in Down's syndrome","volume":"14","author":"Sasaki MS","year":"1969","journal-title":"Jpn J Human Genet"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/0027-5107(70)90089-8"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/0027-5107(78)90045-3"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/258427a0"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/260441a0"}],"container-title":["Teratogenesis, Carcinogenesis, and Mutagenesis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Ftcm.1770010204","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/tcm.1770010204","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,4]],"date-time":"2023-11-04T00:35:08Z","timestamp":1699058108000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/tcm.1770010204"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1981,1]]},"references-count":20,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1981,1]]}},"alternative-id":["10.1002\/tcm.1770010204"],"URL":"https:\/\/doi.org\/10.1002\/tcm.1770010204","archive":["Portico"],"relation":{},"ISSN":["0270-3211","1520-6866"],"issn-type":[{"value":"0270-3211","type":"print"},{"value":"1520-6866","type":"electronic"}],"subject":[],"published":{"date-parts":[[1981,1]]}}}