{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T18:41:01Z","timestamp":1773081661591,"version":"3.50.1"},"reference-count":30,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2005,9,9]],"date-time":"2005-09-09T00:00:00Z","timestamp":1126224000000},"content-version":"vor","delay-in-days":9017,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Teratog Carcinog Mutagen"],"published-print":{"date-parts":[[1981,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Nickel carbonyl was administered to groups of pregnant hamsters by inhalation (0.06 mg Ni(CO)<jats:sub>4<\/jats:sub>\/liter\/15 min) on days 4, 5, 6, 7, or 8 of gestation. The dams were killed on day 15 of gestation, and the fetuses were examined for malformations. Exposure to Ni(CO)<jats:sub>4<\/jats:sub> on days 4 or 5 of gestation resulted in malformations in 5.5% (8\/146) and 5.8% (10\/171) of the progeny, respectively (P &lt; 0.05, versus 0\/95 in controls). The proportions of litters with malformed fetuses were 33% (4\/12) and 24% (4\/17) in dams exposed to Ni(CO)<jats:sub>4<\/jats:sub> on days 4 and 5 of gestation (P &lt; 0.05, versus 0\/9 in litters of control dams). Progeny of dams exposed to Ni(CO)<jats:sub>4<\/jats:sub> on days 4 and 5 included 9 fetuses with cystic lungs, 7 fetuses with exencephaly, 1 fetus with exencephaly plus fused rib, and 1 fetus with anophthalmia plus cleft palate. Hemorrhages into serous cavities were found in 18% (26\/146) and 25% (42\/171) of fetuses of dams exposed to Ni(CO)<jats:sub>4<\/jats:sub> on days 4 or 5 of gestation. Such hemorrhages were not observed in controls. In progeny of dams exposed to Ni(CO)<jats:sub>4<\/jats:sub> on days 6 or 7 of gestation, there was 1 fetus with fused ribs and there were 2 fetuses with hydronephrosis. In another experiment, pregnant hamsters were exposed to inhalation of Ni(CO)<jats:sub>4<\/jats:sub> (0.06 mg\/liter\/15 min) on day 5 of gestation; these dams were permitted to deliver their litters and to nurse their pups. On the day of delivery, there was no significant difference in the average number of live pups in the Ni(CO)<jats:sub>4<\/jats:sub>\u2010exposed litters compared to control litters. Neonatal mortality was increased in Ni(CO)<jats:sub>4<\/jats:sub>\u2010exposed litters; by day 4 postpartum, the number of live pups averaged 7.6 \u00b1 1.5 in Ni(CO)<jats:sub>4<\/jats:sub>\u2010exposed litters (P &lt; 0.01 versus 9.6 \u00b1 1.8 pups in control litters). This study demonstrates that Ni(CO)<jats:sub>4<\/jats:sub> is teratogenic and embryotoxic in Syrian hamsters.<\/jats:p>","DOI":"10.1002\/tcm.1770010210","type":"journal-article","created":{"date-parts":[[2006,2,4]],"date-time":"2006-02-04T12:17:34Z","timestamp":1139055454000},"page":"223-233","source":"Crossref","is-referenced-by-count":24,"title":["Teratogenicity and embryotoxicity of nickel carbonyl in Syrian hamsters"],"prefix":"10.1002","volume":"1","author":[{"suffix":"Jr.","given":"F. William","family":"Sunderma","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samuel K.","family":"Shen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marilyn C.","family":"Reid","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patricia R.","family":"Allpass","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,9,9]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"1","volume-title":"Nickel","author":"National Research Council (Committee on Medical and Biological Effects of Environmental Pollutants)","year":"1975"},{"key":"e_1_2_1_3_2","series-title":"IARC Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Man","first-page":"75","volume-title":"Nickel and nickel compounds","author":"International Agency for Research on Cancer","year":"1976"},{"key":"e_1_2_1_4_2","series-title":"DHEW\/NIOSH Publication No. 77\u2010164","first-page":"1","volume-title":"Criteria for a Recommended Standard: Occupational Exposure to Inorganic Nickel","author":"National Institute for Occupational Safety and Health","year":"1977"},{"key":"e_1_2_1_5_2","first-page":"377","article-title":"A review of the metabolism and toxicology of nickel","volume":"7","author":"Sunderman FW","year":"1977","journal-title":"Ann Clin Lab Sci"},{"key":"e_1_2_1_6_2","first-page":"541","volume-title":"Handbook on the Toxicology of Metals","author":"Norseth T","year":"1979"},{"key":"e_1_2_1_7_2","unstructured":"SundermanFWJr; Recent research on nickel carcinogenesis.Environ Health Perspect1980(in press)."},{"key":"e_1_2_1_8_2","first-page":"70","article-title":"Toxicity of nickel","volume":"9","author":"Phatak SS","year":"1950","journal-title":"J Sci Industr Res"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1952.tb26536.x"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1080\/00039896.1971.10665963"},{"key":"e_1_2_1_11_2","first-page":"51","volume-title":"Advances in Teratology, Vol 5","author":"Ferm VH","year":"1972"},{"key":"e_1_2_1_12_2","first-page":"181","article-title":"Long\u2010term toxicologic assessment of nickel in rats and dogs","volume":"13","author":"Ambrose AM","year":"1976","journal-title":"J Food Sci Technol"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/0041-008X(78)90017-0"},{"key":"e_1_2_1_14_2","first-page":"86","article-title":"Embryotoxic effect of nickel ingested with drinking water","volume":"6","author":"Nadeenko VG","year":"1979","journal-title":"Gig Sanit"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.104388"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420190202"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01055496"},{"key":"e_1_2_1_18_2","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1093\/ajcp\/26.2.107","article-title":"Nickel poisoning. III. Procedures for detection, prevention, and treatment of nickel carbonyl exposure including a method for the determination of nickel in biological materials","volume":"26","author":"Kinkaid JF","year":"1956","journal-title":"Am J Clin Pathol"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1080\/00039896.1968.10665163"},{"key":"e_1_2_1_20_2","first-page":"251","volume-title":"Teratology, Principles and Techniques","author":"Wilson JG","year":"1965"},{"key":"e_1_2_1_21_2","first-page":"145","volume-title":"Teratology, Principles and Techniques","author":"Murphy ML","year":"1965"},{"key":"e_1_2_1_22_2","first-page":"677","article-title":"Comparisons of antidotal efficacy of sodium diethylthiocarbamate, D\u2010penicillamine, and triethylenetetramine upon acute toxicity of nickel carbonyl in rats","volume":"18","author":"Baselt RC","year":"1977","journal-title":"Res Commun Chem Pathol Pharmacol"},{"key":"e_1_2_1_23_2","first-page":"59","volume-title":"Biostatistical Analysis","author":"Zar JH","year":"1974"},{"key":"e_1_2_1_24_2","first-page":"245","article-title":"Placental transfer of NiCl2 to fetuses in mice","volume":"14","author":"Lu C\u2010C","year":"1976","journal-title":"Teratology"},{"key":"e_1_2_1_25_2","first-page":"571","article-title":"Nickel and strontium distribution in some mouse tissues: Passage through placenta and mammary glands","volume":"20","author":"Jacobsen N","year":"1978","journal-title":"Res Commun Chem Pathol Pharmacol"},{"key":"e_1_2_1_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/0300-483X(79)90043-X"},{"key":"e_1_2_1_27_2","volume-title":"Proceedings of the International Symposium on Arsenic and Nickel","author":"Schneider HJ","year":"1981"},{"key":"e_1_2_1_28_2","doi-asserted-by":"publisher","DOI":"10.1079\/BJN19780079"},{"key":"e_1_2_1_29_2","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1093\/clinchem\/17.11.1123","article-title":"Abnormal concentrations of nickel in serum in cases of myocardial infarction, stroke, burns, hepatic cirrhosis, and uremia","volume":"17","author":"McNeely MD","year":"1971","journal-title":"Clin Chem"},{"key":"e_1_2_1_30_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01685587"},{"key":"e_1_2_1_31_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.424746"}],"container-title":["Teratogenesis, Carcinogenesis, and Mutagenesis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Ftcm.1770010210","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/tcm.1770010210","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,4]],"date-time":"2023-11-04T00:34:48Z","timestamp":1699058088000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/tcm.1770010210"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1981,1]]},"references-count":30,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1981,1]]}},"alternative-id":["10.1002\/tcm.1770010210"],"URL":"https:\/\/doi.org\/10.1002\/tcm.1770010210","archive":["Portico"],"relation":{},"ISSN":["0270-3211","1520-6866"],"issn-type":[{"value":"0270-3211","type":"print"},{"value":"1520-6866","type":"electronic"}],"subject":[],"published":{"date-parts":[[1981,1]]}}}