{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,19]],"date-time":"2023-10-19T22:40:42Z","timestamp":1697755242451},"reference-count":36,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2005,9,9]],"date-time":"2005-09-09T00:00:00Z","timestamp":1126224000000},"content-version":"vor","delay-in-days":7922,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Teratog Carcinog Mutagen"],"published-print":{"date-parts":[[1984,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The synthetic prostaglandin ONO\u2010802 was administered intravaginally to Sprague Dawley rats at doses of 1.0, 0.5, and 0.125 mg\/kg on days 6 through 15 of gestation. A vehicle control group was treated with pessaries that did not contain the drug while another group remained untreated. Body weight, food, water consumption, and clinical signs were monitored during the experiment. In Phase One, 20 pregnant animals from each group were sacrificed at term, major organs were weighed, and litter and fetal data were collected. In Phase Two ten dams per group were allowed to deliver their litters, and the offspring were evaluated for survival, growth, developmental signs, and physiological function. Selected F<jats:sub>1<\/jats:sub> offspring were retained to assess learning and emotional behavior or reproductive capacity.<\/jats:p><jats:p>Administration of either 0.5 or 1.0 mg\/kg of ONO\u2010802 resulted in a slight reduction in food consumption and body weight gain. Water consumption was increased both during and after the dosing period for the mid and high dose dams. Significantly increased weights for the heart, lungs, liver, adrenals, and ovaries and decreased weights for the thymus gland were noted at term sacrifice of the 1.0 mg\/kg dams, whereas the 0.5 mg\/kg group had increased weights of the adrenals and ovaries only. Litter parameters were unaffected by treatment. Weights of the female fetuses of the 1.0 and 0.5 mg\/kg groups were significantly reduced when compared to controls. There were no significant drug\u2010related abnormalities among the F<jats:sub>1<\/jats:sub> offspring and no evidence that treatment of the F<jats:sub>0<\/jats:sub> dams affected the development, behavior, or reproductive performance of the F<jats:sub>1<\/jats:sub> offspring. Thus, ONO\u2010802 was not teratogenic when given to rats by the intravaginal route.<\/jats:p>","DOI":"10.1002\/tcm.1770040208","type":"journal-article","created":{"date-parts":[[2006,2,4]],"date-time":"2006-02-04T04:21:20Z","timestamp":1139026880000},"page":"233-243","source":"Crossref","is-referenced-by-count":1,"title":["Two\u2010phase teratology study with the synthetic prostaglandin ONO\u2010802 given intravaginally to rats"],"prefix":"10.1002","volume":"4","author":[{"given":"Judith A.","family":"Petrere","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ronald R.","family":"Humphrey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raymond","family":"Sakowski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James 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