{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T01:56:31Z","timestamp":1791078991199,"version":"4.1.0"},"reference-count":15,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2005,9,9]],"date-time":"2005-09-09T00:00:00Z","timestamp":1126224000000},"content-version":"vor","delay-in-days":7922,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Teratog Carcinog Mutagen"],"published-print":{"date-parts":[[1984,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>2,3,7,8\u2010Tetrachlorodibenzo\u2010p\u2010dioxin (TCDD) causes a high percentage of cleft palate in fetuses when administered during organogenesis in certain strains of mice including the C57BL\/6J, but not in certain other strains (AKR\/J). The purpose of the present study was to examine various biochemical and morphological aspects of TCDD\u2010induced changes in the developing palatal shelves. Our results indicate that when TCDD (100 \u03bcg\/kg) was given on individual days between days 8 and 10 of gestation, a high percentage of cleft palate was observed. Receptors specific for TCDD were detected in the C57BL\/6J but not AKR\/J palatal shelves. The amount of TCDD receptors is highest in the palatal shelves on day 13 as compared to other embryonic tissues including the liver. Examination of cryostat sections taken from embryos during the time of palatal elevation and fusion demonstrated that TCDD does not interfere with growth, elevation, or initial contact of the palatal shelves, but does interfere with firm adhesion and\/or degeneration of the medial epithelial cells. Our results suggest that TCDD exerts a direct effect on the embryonic palatal shelves which results in formation of cleft palate.<\/jats:p>","DOI":"10.1002\/tcm.1770040505","type":"journal-article","created":{"date-parts":[[2006,2,4]],"date-time":"2006-02-04T11:56:01Z","timestamp":1139054161000},"page":"427-436","source":"Crossref","is-referenced-by-count":81,"title":["2,3,7,8\u2010Tetrachlorodibenzo\u2010p\u2010dioxin\u2010 induced cleft palate in the mouse: Evidence for alterations in palatal shelf fusion"],"prefix":"10.1002","volume":"4","author":[{"given":"Robert M.","family":"Pratt","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lennart","family":"Dencker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virginia M.","family":"Diewert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,9,9]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"86","article-title":"2,3,7,8\u2010tetrachlorodibenzo\u2010p\u2010dioxin: Segregation of toxicity with the Ah locus","volume":"17","author":"Poland A","year":"1980","journal-title":"Mol Pharmacol"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.pa.22.040182.002505"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.3109\/10409237909105427"},{"key":"e_1_2_1_5_2","doi-asserted-by":"crossref","first-page":"11636","DOI":"10.1016\/S0021-9258(19)86532-8","article-title":"Regulatory gene product of the Ah locus: Characterization of the cytosolic inducer receptor complex and evidence for its nuclear translocation","volume":"254","author":"Okey AB","year":"1979","journal-title":"J Biol Chem"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0041-008X(71)90282-1"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/0165-6147(83)90343-7"},{"key":"e_1_2_1_8_2","first-page":"609","article-title":"Palatal process movement in the rat as demonstrated in frozen sections","volume":"128","author":"Diewert VM","year":"1979","journal-title":"J Anat"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1949.tb27297.x"},{"key":"e_1_2_1_10_2","first-page":"397","article-title":"Distribution, excretion, and metabolism of TCDD in C57BL\/6J, DBA\/2J, B6\u2010B2, and F1\u2010J mice","volume":"11","author":"Gasiewicz TA","year":"1983","journal-title":"Drug Metab Dispos"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420240206"},{"key":"e_1_2_1_12_2","first-page":"19","article-title":"In vitro development of palatal tissues from embryonic mice","volume":"38","author":"Tyler MS","year":"1977","journal-title":"J Embryol Exp Morphol"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/0300-483X(81)90037-8"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/tcm.1770010408"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.77.6.3524"},{"key":"e_1_2_1_16_2","doi-asserted-by":"crossref","first-page":"9814","DOI":"10.1016\/S0021-9258(19)83589-5","article-title":"Nuclear uptake of 2,3,7,8\u2010tetrachlorodibenzo\u2010p\u2010dioxin in C57BL\/6J and DBA\/2J mice","volume":"254","author":"Greenlee WF","year":"1979","journal-title":"J Biol Chem"}],"container-title":["Teratogenesis, Carcinogenesis, and Mutagenesis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Ftcm.1770040505","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/tcm.1770040505","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,19]],"date-time":"2023-10-19T21:05:39Z","timestamp":1697749539000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/tcm.1770040505"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1984,1]]},"references-count":15,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1984,1]]}},"alternative-id":["10.1002\/tcm.1770040505"],"URL":"https:\/\/doi.org\/10.1002\/tcm.1770040505","archive":["Portico"],"relation":{},"ISSN":["0270-3211","1520-6866"],"issn-type":[{"value":"0270-3211","type":"print"},{"value":"1520-6866","type":"electronic"}],"subject":[],"published":{"date-parts":[[1984,1]]}}}