{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T04:34:34Z","timestamp":1774067674505,"version":"3.50.1"},"reference-count":10,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2005,9,9]],"date-time":"2005-09-09T00:00:00Z","timestamp":1126224000000},"content-version":"vor","delay-in-days":7191,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Teratog Carcinog Mutagen"],"published-print":{"date-parts":[[1986,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The present study is an evaluation of the developmental toxicity of dinocap in three rodent species using an in vivo teratology screen. Our protocol uses postnatal viability, weight gain, and morphological and behavioral development through weaning to assess the developmental toxicity of compounds.<\/jats:p><jats:p>Dinocap administered orally on days 7 to 16 of gestation to the CD\u20101 mouse resulted in increased postnatal mortality at 25 mg\/kg\/d (80% in block 1 and 40% in block 2). Many of the treated pups that died during the neonatal period were \u201cballooned\u201d and had cleft palates. Although there was no treatment related mortality in the 12 mg\/kg\/d dosage group, 6% (14\/226) of these mice and 24% (23\/96) of the survivors from the 25 mg\/kg\/d dosage group displayed torticollis (a twisting of the neck resulting in an abnormal tilting of the head). These tilted\u2010head mice held the head and forepart of the body tilted constantly to one side, both when resting and walking. The tilt was in either direction but was always constant for a given animal; in different mice, the angle varied considerably from almost 0 to 30\u00b0. Some mice circled repeatedly in one direction in the home cage, others bobbed their heads and did back\u2010flips, while others rolled over, always rolling in the same direction.<\/jats:p><jats:p>In the hamster, developmental toxicity was seen at (100 and 200 mg\/kg\/d) or near (50 mg\/kg\/d) maternally toxic doses but no behavioral alterations were noted and none of the pups were ballooned.<\/jats:p><jats:p>The highest dose of dinocap (100 mglkgld during days 7\u201320) used in the rat study produced mild maternal toxicity (reduced maternal weight gain from day 3 to 10 of gestation), but did not alter the postnatal development of this species.<\/jats:p>","DOI":"10.1002\/tcm.1770060105","type":"journal-article","created":{"date-parts":[[2006,2,3]],"date-time":"2006-02-03T21:54:19Z","timestamp":1139003659000},"page":"33-43","source":"Crossref","is-referenced-by-count":18,"title":["Prenatal exposure to the fungicide dinocap causes behavioral torticollis, ballooning and cleft palate in mice, but not rats or hamsters"],"prefix":"10.1002","volume":"6","author":[{"suffix":"Jr.","given":"L. Earl","family":"Gray","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John M.","family":"Rogers","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert J.","family":"Kavlock","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph S.","family":"Ostby","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janet M.","family":"Ferrell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katrina L.","family":"Gray","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,9,9]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"872","article-title":"Note on a new gas chromatographic procedure for the total active ingredient content of karathane technical","volume":"52","author":"Kurtz CP","year":"1969","journal-title":"J Assoc Off Anal Chem"},{"issue":"1","key":"e_1_2_1_3_2","first-page":"31","article-title":"Acute and chronic toxicity studies on 2,4\u2010dinitro\u20106 (1\u2010methylheptyl) phenyl crotonate (karathane)","author":"Larson PS","year":"1959","journal-title":"Arch Int Pharmacodyn Ther"},{"key":"e_1_2_1_4_2","first-page":"351","article-title":"Toxicity studies on dinocap. Part V. Preliminary studies on effects on the reproduction","author":"Fraczek S","year":"1979","journal-title":"Bromat Chem Toksykol"},{"key":"e_1_2_1_5_2","first-page":"373","article-title":"Toxicity studies on dinocap. Part I. Acute toxicity","author":"Mlodecki H","year":"1975","journal-title":"Bromat Chem Toksykol"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/tcm.1770040504"},{"key":"e_1_2_1_7_2","unstructured":"ChernoffN KavlockRJ: Anin vivoteratology screen utilizing pregnant mice.J Toxicol Environ Health10541\u2013550 1982."},{"key":"e_1_2_1_8_2","first-page":"1","volume-title":"Behavioral Toxicology: An Emerging Discipline","author":"Reiter L","year":"1977"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1951.sp004632"},{"key":"e_1_2_1_10_2","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1093\/jn\/100.6.643","article-title":"Congenital ataxia and otolith defects due to manganese deficiency in mice","volume":"100","author":"Erway L","year":"1970","journal-title":"J Nutr"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/0300-483X(81)90155-4"}],"container-title":["Teratogenesis, Carcinogenesis, and Mutagenesis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Ftcm.1770060105","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/tcm.1770060105","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,21]],"date-time":"2023-10-21T22:30:39Z","timestamp":1697927439000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/tcm.1770060105"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1986,1]]},"references-count":10,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1986,1]]}},"alternative-id":["10.1002\/tcm.1770060105"],"URL":"https:\/\/doi.org\/10.1002\/tcm.1770060105","archive":["Portico"],"relation":{},"ISSN":["0270-3211","1520-6866"],"issn-type":[{"value":"0270-3211","type":"print"},{"value":"1520-6866","type":"electronic"}],"subject":[],"published":{"date-parts":[[1986,1]]}}}