{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T22:30:53Z","timestamp":1762641053394},"reference-count":22,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2005,9,9]],"date-time":"2005-09-09T00:00:00Z","timestamp":1126224000000},"content-version":"vor","delay-in-days":7191,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Teratog Carcinog Mutagen"],"published-print":{"date-parts":[[1986,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The tolerance of <jats:italic>Drosophila melanogaster<\/jats:italic> to heavy metal compounds was investigated with special emphasis on methylmercury. A pronounced variation in tolerance to CH<jats:sub>3<\/jats:sub>HgOH, HgCl<jats:sub>2<\/jats:sub>, (C<jats:sub>2<\/jats:sub>H<jats:sub>5<\/jats:sub>)<jats:sub>3<\/jats:sub>PbCl, (CH<jats:sub>3<\/jats:sub>)<jats:sub>3<\/jats:sub>SnCl, and CdCl<jats:sub>2<\/jats:sub> was recorded between 12 wild\u2010type strains. After ranking the tolerance of the strains with respect to the five compounds rank correlations for experiments within and between compounds were calculated. The results showed a high degree of correlation within compounds but no unequivocal indication of a correlation between compounds, indicating that different mechanisms of genetic control for tolerance were operating for the five compounds. Rank correlations for experiments with 12 different mercury, lead, tin, and cadmium compounds and the same 12 wild\u2010type strains only indicated one significant correlated response, between tripropyltin and tributyltin.<\/jats:p><jats:p>A selection experiment for tolerance to methylmercury was performed with a foundation population, synthesized from four wild\u2010type strains, showing a high initial tolerance. One control and two levels of treatment doses were used. A distinct selection response was obtained and a high tolerance was reached particularly for the high\u2010dose selection line after 12 generations, when the experiment ended. Genetic analysis of the tolerance indicated a dominant and polygenic inheritance. Investigation of the uptake and excretion of CH<jats:sub>3<\/jats:sub>Hg<jats:sup>203<\/jats:sup>OH showed that the level of tolerance to methylmercury was correlated with the uptake of the mercury but apparently not with the rate of excretion.<\/jats:p><jats:p>Cystein increased the susceptibility to methylmercury. Inorganic mercury and trimethyl lead exhibited a synergistic toxic effect, evidently as the result of an in vitro transmethylation of mercury.<\/jats:p><jats:p>A high somatic susceptibility to methylmercury also applied to the induction of nondisjunction and sex\u2010linked recessive lethals.<\/jats:p>","DOI":"10.1002\/tcm.1770060405","type":"journal-article","created":{"date-parts":[[2006,2,4]],"date-time":"2006-02-04T04:20:43Z","timestamp":1139026843000},"page":"289-305","source":"Crossref","is-referenced-by-count":31,"title":["Genetic variation in the susceptibility to mercury and other metal compounds in <i>Drosophila melanogaster<\/i>"],"prefix":"10.1002","volume":"6","author":[{"given":"Jan","family":"Magnusson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claes","family":"Ramel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,9,9]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"141","volume-title":"Mercury in the environment","author":"Skerfving S","year":"1972"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-5223.1969.tb01838.x"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-5223.1969.tb01839.x"},{"key":"e_1_2_1_5_2","first-page":"169","volume-title":"Mercury in the Environment","author":"Ramel C","year":"1972"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-5223.1978.tb01627.x"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.793159"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/0009-2797(83)90029-7"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0027-5107(74)80032-1"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410070412"},{"key":"e_1_2_1_11_2","first-page":"79","article-title":"A study on methylmercury concentration in the umbilical cords of the inhabitants born in Minamata area","volume":"9","author":"Harade M","year":"1977","journal-title":"Brain Dev"},{"key":"e_1_2_1_12_2","series-title":"Carnegie Inst Wash Publ 627","volume-title":"Genetic variations of Drosophila melanogaster","author":"Lindsley DL","year":"1968"},{"key":"e_1_2_1_13_2","volume-title":"Statistical Methods","author":"Snedecor GW","year":"1971"},{"key":"e_1_2_1_14_2","first-page":"29","article-title":"Organolead compounds shown to be genetically active","volume":"1","author":"Ahlberg J","year":"1972","journal-title":"Ambio"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/0300-483X(83)90090-2"},{"key":"e_1_2_1_16_2","first-page":"494","article-title":"The connection between c\u2010mitotic activity and water solubility in some monocyclic compounds","volume":"29","author":"\u00d6stergren G","year":"1943","journal-title":"Hereditas"},{"key":"e_1_2_1_17_2","first-page":"77","article-title":"Narcotized mitosis and the precipitation hypothesis of narcosis. Mechanisme de la narcose","volume":"26","author":"\u00d6stergren G","year":"1951","journal-title":"Colloq Int Centre Nat Rech Sci"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/0300-483X(73)90017-6"},{"key":"e_1_2_1_19_2","first-page":"119","article-title":"Studies on the transmural movements of mercury compounds by rat small intestine, effect of coexisting substances on the permeability","volume":"27","author":"Matsumoto H","year":"1972","journal-title":"Jpn J Hyg"},{"key":"e_1_2_1_20_2","first-page":"390","article-title":"Heavy metals and adenosine cyclic 3\u20325\u2032 monophosphate metabolism. Possible relevance to heavy metal toxicity","volume":"12","author":"Nathanson JA","year":"1976","journal-title":"Mol Pharmacol"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/0009-2797(79)90084-X"},{"key":"e_1_2_1_22_2","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1146\/annurev.ge.11.120177.000405","article-title":"Mutation affecting fibers in Drosophila populations","volume":"11","author":"Simmons MJ","journal-title":"Ann Rev Genet"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/0165-1110(83)90022-2"}],"container-title":["Teratogenesis, Carcinogenesis, and Mutagenesis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Ftcm.1770060405","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/tcm.1770060405","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,20]],"date-time":"2023-10-20T17:05:21Z","timestamp":1697821521000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/tcm.1770060405"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1986,1]]},"references-count":22,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1986,1]]}},"alternative-id":["10.1002\/tcm.1770060405"],"URL":"https:\/\/doi.org\/10.1002\/tcm.1770060405","archive":["Portico"],"relation":{},"ISSN":["0270-3211","1520-6866"],"issn-type":[{"value":"0270-3211","type":"print"},{"value":"1520-6866","type":"electronic"}],"subject":[],"published":{"date-parts":[[1986,1]]}}}