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The treatment induced abnormalities of the neural suture, the severity of which increased in a dose\u2010related manner with the concentration of substrate or enzyme. Glutathione (10 mM) or catalase (50 \u03bcg\/ml) either partially or completely abolished the effects of xanthine\/xanthine oxidase, whereas the addition of superoxide dismutase (50 \u03bcg\/ml) or desferrioxamine (1mM) did not reduce the number of malformed embryos. These findings suggest that hydrogen peroxide and\/or hydroxyl radicals are responsible for the effects of xanthine and xanthine oxidase.<\/jats:p>","DOI":"10.1002\/tcm.1770060608","type":"journal-article","created":{"date-parts":[[2006,2,4]],"date-time":"2006-02-04T01:22:57Z","timestamp":1139016177000},"page":"547-554","source":"Crossref","is-referenced-by-count":36,"title":["Malformations induced in cultured rat embryos by enzymically generated active oxygen species"],"prefix":"10.1002","volume":"6","author":[{"given":"P. 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