{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T04:35:16Z","timestamp":1774067716382,"version":"3.50.1"},"reference-count":8,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2005,9,9]],"date-time":"2005-09-09T00:00:00Z","timestamp":1126224000000},"content-version":"vor","delay-in-days":6826,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Teratog Carcinog Mutagen"],"published-print":{"date-parts":[[1987,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Technical\u2010grade dinocap, a complex\u2010mixture fungicide, is teratogenic in the CD\u20101 mouse, causing cleft palate and otolith defects. In this study we compared the developmental toxicities of 2,4\u2010dinitro\u20106\u2010(1\u2010methylheptyl)phenyl crotonate and 2,6\u2010dinitro\u20104\u2010(1\u2010methylheptyl)phenyl crotonate, model isomers of the major active ingredients of technical dinocap, to the known teratogenicity of the technical compound. Individual isomers, both isomers combined, or technical dinocap were administered to pregnant mice on days 7\u201316 of gestation. Some dams were killed at term and litters were removed, dead fetuses and resorptions were counted, and live fetuses were weighed and preserved in Bodian's fixative for examination for cleft palate. Other treated dams were allowed to give birth: postnatal viability and growth, development of swimming behavior, and otolith formation were evaluated. As in previous studies, technical\u2010grade dinocap caused cleft palate and weight deficits in fetuses at term and increased neonatal mortality and abnormal swimming behavior, torticollis, and deficient otolith formation in surviving pups. Neither of the purified isomers exhibited any developmental toxicity when administered under identical conditions. Thus, it is concluded that these isomers are not the active teratogenic component(s) in technical\u2010grade dinocap.<\/jats:p>","DOI":"10.1002\/tcm.1770070402","type":"journal-article","created":{"date-parts":[[2006,2,4]],"date-time":"2006-02-04T01:18:23Z","timestamp":1139015903000},"page":"341-346","source":"Crossref","is-referenced-by-count":8,"title":["Developmental toxicity of dinocap in the mouse is not due to two isomers of the major active ingredients"],"prefix":"10.1002","volume":"7","author":[{"given":"John M.","family":"Rogers","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr.","given":"L. Earl","family":"Gray","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brenda D.","family":"Carver","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert J.","family":"Kavlock","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,9,9]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"16","volume-title":"Agricultural Chemicals","author":"Rohm and Haas Co.","year":"1961"},{"key":"e_1_2_1_3_2","first-page":"887","article-title":"Gas chromatographic determination of total active ingredient content of Karathane Technical and Karathane WD I. Development of the method","volume":"53","author":"Kurtz CP","year":"1970","journal-title":"J Assoc Off Anal Chem"},{"key":"e_1_2_1_4_2","first-page":"85","article-title":"Dinocap pharmacokinetic study in female rabbits","volume":"6","author":"Longacre SL","year":"1986","journal-title":"Toxicologist"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/tcm.1770060504"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/tcm.1770060105"},{"key":"e_1_2_1_7_2","first-page":"448","article-title":"Effects of the fungicide dinocap on otolith development in the CD\u20101 mouse","volume":"43","author":"Rogers JM","year":"1986","journal-title":"Fed Proc"},{"key":"e_1_2_1_8_2","unstructured":"GrayLE Jr RogersJM OstbyJS FerrellJM GrayKL KavlockRJ: Prenatal dinocap alters the swimming behavior of mice due to agenesis of otoliths in the inner ear.Toxicol Appl Pharmacol(submitted)."},{"key":"e_1_2_1_9_2","first-page":"584","volume-title":"SAS Users Guide: Statistics","author":"SAS Institute, Inc.","year":"1982"}],"container-title":["Teratogenesis, Carcinogenesis, and Mutagenesis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Ftcm.1770070402","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/tcm.1770070402","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,21]],"date-time":"2023-10-21T04:08:22Z","timestamp":1697861302000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/tcm.1770070402"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1987,1]]},"references-count":8,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1987,1]]}},"alternative-id":["10.1002\/tcm.1770070402"],"URL":"https:\/\/doi.org\/10.1002\/tcm.1770070402","archive":["Portico"],"relation":{},"ISSN":["0270-3211","1520-6866"],"issn-type":[{"value":"0270-3211","type":"print"},{"value":"1520-6866","type":"electronic"}],"subject":[],"published":{"date-parts":[[1987,1]]}}}