{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T15:59:50Z","timestamp":1775231990450,"version":"3.50.1"},"reference-count":51,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2005,9,9]],"date-time":"2005-09-09T00:00:00Z","timestamp":1126224000000},"content-version":"vor","delay-in-days":6826,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Teratog Carcinog Mutagen"],"published-print":{"date-parts":[[1987,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Prenatal exposure of males to diethylstilbestrol (DES) results in reproductive tract teratogenesis, ie, retention of M\u00fcllerian duct remnants. The potential of these remnants to develop pathological changes has not been studied. Therefore, pregnant outbred CD\u20101 mice were subcutaneously injected with daily doses of DES (100 \u03bcg\/kg) on days 9 through 16 of gestation. DES\u2010exposed male offspring and age\u2010matched control male mice were sacrificed at 10 to 18 mo of age and examined for reproductive tract abnormalities. Prominent M\u00fcllerian remnants were observed in 268 out of 277 (97%) of the DES\u2010exposed male mice. These remnants differentiated into \u201cfemalelike structures\u201d homologous to oviduct and uterus. The M\u00fcllerian remnants were often enlarged and cystic and shared supporting connective tissue with adjacent male structures. Previously reported lesions, termed \u201cepididymal cysts,\u201d were determined histologically to be cystic \u201coviductlike\u201d structures and were, therefore, considered a M\u00fcllerian duct abnormality. Pathological changes in these male oviductal and uterine homologs included benign and malignant lesions.<\/jats:p><jats:p>In addition, epididymal structures were altered. Inflammation and sperm granulomas were prevalent in DES\u2010treated mice as young as 10 mo old but were only observed in control mice at 18 mos. Cysts of epididymal duct origin, hyperplasia, and adenoma of the epididymal duct were also observed. No comparable abnormalities were noted in 122 control males of corresponding ages.<\/jats:p><jats:p>The data presented in this report demonstrated that transplacental exposure to DES affected the differentiation and normal development of the male genital tract involving both the M\u00fcllerian (paramesonephric) and Wolffian (mesonephric) ducts. The long\u2010term changes in these tissues include lesions, some of which resembled neoplasia although the natural history of the lesions is not known. Moreover, some previously described abnormalities referred to as \u201cepididymal cysts\u201d were associated with tissues derived from embryonic female origin.<\/jats:p>","DOI":"10.1002\/tcm.1770070405","type":"journal-article","created":{"date-parts":[[2006,2,4]],"date-time":"2006-02-04T01:18:41Z","timestamp":1139015921000},"page":"377-389","source":"Crossref","is-referenced-by-count":37,"title":["M\u00fcllerian remnants of male mice exposed prenatally to diethylstilbestrol"],"prefix":"10.1002","volume":"7","author":[{"given":"Retha R.","family":"Newbold","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bill C.","family":"Bullock","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John 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