{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T17:35:31Z","timestamp":1760204131959},"reference-count":43,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2005,9,9]],"date-time":"2005-09-09T00:00:00Z","timestamp":1126224000000},"content-version":"vor","delay-in-days":6461,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Teratog Carcinog Mutagen"],"published-print":{"date-parts":[[1988,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Neonatal female NMRI mice were treated with daily doses of 10<jats:sup>\u22122<\/jats:sup> or 5 \u03bcg diethylstilbestrol (DES) on one or more of days 1\u20135 after birth. Using immunohistochemical techniques and a monoclonal antibody to the estrogen receptor, we demonstrated an estrogen\u2010induced precocious appearance of receptor protein in the nuclei of the uterovaginal epithelium. High levels of peroxidase activity and a pronounced stromal infiltration with peroxidase positive cells occurred in the uterine cervix and upper vagina after estrogen treatment. This regional restriction in peroxidase activity was similar to the regional restriction for estrogen\u2010induced epithelial abnormalities (heterotopic columnar epithelium, adenosis). A combined treatment with DES and corticosterone depressed peroxidase activity but not to the control level. The distribution of abnormal epithelium was similar in DES\u2010and DES\u2010corticosterone\u2010treated females. The conclusion is that neonatal estrogen treatment induces an epithelial receptor for estrogen and a high level of cervical peroxidase activity, but the relationship between these parameters and the appearance of abnormal cervicovaginal epithelial changes could not be settled in the present study.<\/jats:p>","DOI":"10.1002\/tcm.1770080605","type":"journal-article","created":{"date-parts":[[2006,2,4]],"date-time":"2006-02-04T12:25:07Z","timestamp":1139055907000},"page":"347-361","source":"Crossref","is-referenced-by-count":13,"title":["Induction of estrogen receptor, peroxidase activity, and epithelial abnormalities in the mouse uterovaginal epithelium after neonatal treatment with diethylstilbestrol"],"prefix":"10.1002","volume":"8","author":[{"given":"Christer","family":"Andersson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John\u2010Gunnar","family":"Forsberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,9,9]]},"reference":[{"key":"e_1_2_1_2_2","volume-title":"Toxicity of Hormones in Perinatal Life","author":"Forsberg J\u2010G"},{"key":"e_1_2_1_3_2","first-page":"187","article-title":"The development of atypical epithelium in the mouse uterine cervix and vaginal fornix after neonatal estradiol treatment","volume":"50","author":"Forsberg J\u2010G","year":"1969","journal-title":"Br J Exp Pathol"},{"key":"e_1_2_1_4_2","first-page":"721","article-title":"Neonatal estrogen treatment and epithelial abnormalities in the cervicovaginal epithelium of adult mice","volume":"41","author":"Forsberg J\u2010G","year":"1981","journal-title":"Cancer Res"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(82)80177-9"},{"key":"e_1_2_1_6_2","first-page":"56","article-title":"Experimental study of the effect of diethylstilbestrol on the development of the human female reproductive tract","volume":"4","author":"Taguchi O","year":"1983","journal-title":"Biol Res Pregnancy Perinatol"},{"key":"e_1_2_1_7_2","first-page":"26","volume-title":"Developmental Effects of Diethylstilbestrol (DES) in Pregnancy","author":"Scully RE","year":"1981"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-4731(83)80011-9"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-0436.1976.tb00905.x"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-452811-6.50016-5"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-4731(79)90320-0"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-4731(80)90100-4"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/aja.1001770211"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-4731(82)90201-1"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1159\/000142780"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/0012-1606(76)90056-7"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.62.2.449"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(85)90270-9"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.3109\/00498258509045333"},{"key":"e_1_2_1_20_2","first-page":"919","article-title":"Oxidative metabolism of diethylstilbestrol by prostaglandin synthetase","volume":"42","author":"Degen GH","year":"1982","journal-title":"Cancer Res"},{"key":"e_1_2_1_21_2","doi-asserted-by":"crossref","first-page":"16865","DOI":"10.1016\/S0021-9258(19)75968-7","article-title":"Cytochrome P\u2010450\u2010mediated redox cycling of estrogens","volume":"261","author":"Liehr JG","year":"1986","journal-title":"J Biol Chem"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01002631"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.74.8.3162"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(72)90094-2"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01003075"},{"key":"e_1_2_1_26_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/55.3.283"},{"key":"e_1_2_1_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(73)90687-X"},{"key":"e_1_2_1_28_2","first-page":"41","article-title":"Studies on the developmental mechanism of estrogen\u2010induced irreversible changes in the mouse cervicovaginal epithelium","volume":"51","author":"Forsberg J\u2010G","year":"1979","journal-title":"Natl Cancer Inst Monogr"},{"key":"e_1_2_1_29_2","doi-asserted-by":"publisher","DOI":"10.1210\/endo-119-1-390"},{"key":"e_1_2_1_30_2","first-page":"273","volume-title":"Estrogens in the Environment II. 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