{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,14]],"date-time":"2023-11-14T01:18:57Z","timestamp":1699924737553},"reference-count":22,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2005,9,9]],"date-time":"2005-09-09T00:00:00Z","timestamp":1126224000000},"content-version":"vor","delay-in-days":5730,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Teratog Carcinog Mutagen"],"published-print":{"date-parts":[[1990,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The role of genetics in the expression of a complex syndrome of teratologically induced congenital malformations was examined by the use of three inbred strains and 15 related crosses of mice. The syndrome, which included various limb, brain, orofacial, gastrointestinal, and miscellaneous malformations, was induced by an intense riboflavin deficiency produced by feeding the antagonist galactoflavin during midgestation. Analyses of the data showed that, although all three strains shared the major and most other features of the syndrome, there occurred in its manifestation vast quantitative and qualitative differences among them, in which they were resembled by their related crosses, such as to constitute strain\u2010specific malformation patterns. The results can be regarded as typifying an animal counterpart of human situations, the three strains representing in toto the mouse family, each strain individually exhibiting the variety that occurs between siblings in expressing a single syndrome.<\/jats:p>","DOI":"10.1002\/tcm.1770100504","type":"journal-article","created":{"date-parts":[[2006,2,4]],"date-time":"2006-02-04T12:47:08Z","timestamp":1139057228000},"page":"385-397","source":"Crossref","is-referenced-by-count":3,"title":["Analysis of the syndrome of congenital malformations induced in genetically defined mice by acute riboflavin deficiency"],"prefix":"10.1002","volume":"10","author":[{"given":"H.","family":"Kalter","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,9,9]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.92.2391.383"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.1959.39.1.69"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/58.1.125"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/jez.1401360308"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/jmor.1051120307"},{"key":"e_1_2_1_7_2","first-page":"57","volume-title":"Teratology: Principles and Techniques","author":"Kalter H","year":"1965"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420010208"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.3181\/00379727-107-26640"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1177\/00220345620410051101"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420120306"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420190102"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420200206"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420210317"},{"key":"e_1_2_1_15_2","volume-title":"Congenital Malformations: Notes and Comments","author":"Warkany J","year":"1971"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1159\/000239839"},{"key":"e_1_2_1_17_2","first-page":"27A","article-title":"Analysis of malformation syndromes produced by acute riboflavin deficiency in mice","volume":"13","author":"Kalter H","year":"1976","journal-title":"Teratology"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1017\/S1120962300025452"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0001566000007819"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320190307"},{"key":"e_1_2_1_21_2","first-page":"479","article-title":"Growth rate and number of spontaneous mammary carcinomas and riboflavin concentration of liver, muscle, and tumor of C3H mice as influenced by dietary riboflavin","volume":"3","author":"Morris HP","year":"1943","journal-title":"JNCI"},{"key":"e_1_2_1_22_2","volume-title":"The Pathology of Development: A Study of Inherited Skeletal Disorders in Animals","author":"Gr\u00fcneberg H","year":"1963"},{"key":"e_1_2_1_23_2","first-page":"1","article-title":"Experimental production of congenital malformations in strains of inbred mice by maternal treatment with hypervitaminosis A","volume":"38","author":"Kalter H","year":"1961","journal-title":"Am J Pathol"}],"container-title":["Teratogenesis, Carcinogenesis, and Mutagenesis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Ftcm.1770100504","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/tcm.1770100504","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,22]],"date-time":"2023-10-22T16:58:47Z","timestamp":1697993927000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/tcm.1770100504"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1990,1]]},"references-count":22,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1990,1]]}},"alternative-id":["10.1002\/tcm.1770100504"],"URL":"https:\/\/doi.org\/10.1002\/tcm.1770100504","archive":["Portico"],"relation":{},"ISSN":["0270-3211","1520-6866"],"issn-type":[{"value":"0270-3211","type":"print"},{"value":"1520-6866","type":"electronic"}],"subject":[],"published":{"date-parts":[[1990,1]]}}}