{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T17:40:40Z","timestamp":1760204440701},"reference-count":30,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2005,9,9]],"date-time":"2005-09-09T00:00:00Z","timestamp":1126224000000},"content-version":"vor","delay-in-days":5730,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Teratog Carcinog Mutagen"],"published-print":{"date-parts":[[1990,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The effects of two bioresponse modifiers, krestin (PSK) and levamisole hydrochloride (levamisole), on 5\u2010azacytidine (5\u2010AC)\u2010induced syndactyly, brachydactyly, and ectrodac\u2010tyly were investigated. Both PSK and levamisole suppressed 5\u2010AC\u2010induced digital malformations in the rat. The effect of PSK was significant when given 24 h before to 1 h after 5\u2010AC treatment, and levamisole when given 12 h before to 3 h after treatment. Both agents showed an immune\u2010stimulating effect and have been used as cancer chemotherapeutic drugs. However, as the contribution of fetal or maternal immune functions or the alleviation action is unknown, further investigations are required to clarify the mechanism.<\/jats:p>","DOI":"10.1002\/tcm.1770100506","type":"journal-article","created":{"date-parts":[[2010,7,9]],"date-time":"2010-07-09T09:19:51Z","timestamp":1278667191000},"page":"409-415","source":"Crossref","is-referenced-by-count":2,"title":["Suppressive effects of two bioresponse modifiers, Krestin and Levamisole, on 5\u2010azacytidine\u2010induced digital defects in rats"],"prefix":"10.1002","volume":"10","author":[{"given":"Akihiro","family":"Kurishita","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,9,9]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420350211"},{"key":"e_1_2_1_3_2","unstructured":"KurishitaA IharaT: Inhibitory effects of cobalt chloride and cinnamaldehyde on 5\u2010azacytidine induced digital malformations in rats.Teratology(in press)."},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-230X(08)60678-8"},{"key":"e_1_2_1_5_2","first-page":"817","article-title":"Mutagenisity of 5\u2010azacytidine and related nucleosides in C3H 10T1\/2 clone 8 and V79 cells","volume":"42","author":"Landolph JR","year":"1982","journal-title":"Cancer Res"},{"key":"e_1_2_1_6_2","volume-title":"Ciba Symposium on Mutation in Cellular Process","author":"Witkin EM","year":"1969"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/0027-5107(88)90200-X"},{"key":"e_1_2_1_8_2","first-page":"1342","article-title":"Comparative inhibiting effects of methylxanthines on urethan\u2010induced tumors, malformations, and presumed somatic mutations in mice","volume":"43","author":"Nomura T","year":"1983","journal-title":"Cancer Res"},{"key":"e_1_2_1_9_2","first-page":"5156","article-title":"Antiteratogenic effects of tumor inhibitors, caffeine, antipain, and retinoic acid in mice","volume":"43","author":"Nomura T","year":"1983","journal-title":"Cancer Res"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420390208"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1741-4520.1989.tb00735.x"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/0027-5107(88)90230-8"},{"key":"e_1_2_1_13_2","first-page":"11","volume-title":"Environment and Birth Defects","author":"Wilson JG","year":"1973"},{"key":"e_1_2_1_14_2","first-page":"3155","article-title":"Study on safety of KW\u20102\u2010LE\u2010T (Levamisole ? 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Abstracts of the 13th International Congress of Chemotherapy 450 1983."},{"key":"e_1_2_1_29_2","first-page":"257","article-title":"Effect of host\u2010mediated antitumor drugs on hepatic drug\u2010metabolizing enzymes","volume":"6","author":"Hashimoto Y","year":"1979","journal-title":"Cancer Chemother"},{"key":"e_1_2_1_30_2","first-page":"1699","article-title":"Influence of immunomodulators on the activation of masked compound such as futoraful & cyclophosphamide","volume":"7","author":"Maezawa S","year":"1980","journal-title":"Cancer Chemother"},{"key":"e_1_2_1_31_2","first-page":"89","article-title":"Pharmacokinetic studies on levamisole","volume":"23","author":"Koyama K","year":"1982","journal-title":"Appl Pharmacol"}],"container-title":["Teratogenesis, Carcinogenesis, and Mutagenesis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Ftcm.1770100506","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/tcm.1770100506","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,22]],"date-time":"2023-10-22T16:59:01Z","timestamp":1697993941000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/tcm.1770100506"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1990,1]]},"references-count":30,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1990,1]]}},"alternative-id":["10.1002\/tcm.1770100506"],"URL":"https:\/\/doi.org\/10.1002\/tcm.1770100506","archive":["Portico"],"relation":{},"ISSN":["0270-3211","1520-6866"],"issn-type":[{"value":"0270-3211","type":"print"},{"value":"1520-6866","type":"electronic"}],"subject":[],"published":{"date-parts":[[1990,1]]}}}