{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T12:51:59Z","timestamp":1761310319689},"reference-count":224,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2005,9,9]],"date-time":"2005-09-09T00:00:00Z","timestamp":1126224000000},"content-version":"vor","delay-in-days":5730,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Teratog Carcinog Mutagen"],"published-print":{"date-parts":[[1990,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Bacterial ancestry of mitochondria and plastids is now generally accepted. Both organelles contain their own DNA and transcription\u2010translation apparatus of a prokaryotic type. Due to this fact these systems carry bacteria\u2010like properties. Thus organellar DNA and ribosomes are essentially different from nuclear DNA and cytoplasmic ribosomes in physical as well as in functional respects. Due to the bacterial character of both types of organelles they are susceptible to various antibacterial chemicals. Inhibitors of bacterial protein synthesis inhibit mitochondrial (plastidial) biogenesis. Therefore the cellular content of mitochondria (plastids)\u2010made proteins decreases during cytoplasmic turnover or cell division in the presence of these drugs. Such drug activity consequently leads to a reduced capacity for oxidative phosphorylation or photosynthesis. Organellar genomes are less stable and more sensitive to mutagenesis as compared to nuclear genome. It means also that genotoxic agents induce various disorders of mitochondrial (plastidial) functions. Impairments in the respiratory chain are associated with structural as well as functional abnormalities of mitochondria. These are clinically expressed mostly in tissues with a high demand for ATP: brain, heart, skeletal muscle, and retina. On the other hand, some antibacterial inhibitors of mitochondrial biogenesis (e.g., tetracyclines) inhibit selectively tumor cell proliferation. Therefore they may be considered for use in anticancer therapy.<\/jats:p><jats:p>The article summarizes the response of mitochondria and plastids in various organisms to drugs and environmental xenobiotics. Various model organisms suitable for detection of xenobiotic effect on mitochondria (plastids) are presented as well as the possible consequences of such interaction.<\/jats:p>","DOI":"10.1002\/tcm.1770100606","type":"journal-article","created":{"date-parts":[[2006,2,3]],"date-time":"2006-02-03T21:58:05Z","timestamp":1139003885000},"page":"477-501","source":"Crossref","is-referenced-by-count":19,"title":["Interaction of drugs with extranuclear genetic elements and its consequences"],"prefix":"10.1002","volume":"10","author":[{"given":"Libor","family":"Ebringer","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,9,9]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.71.7.2777"},{"key":"e_1_2_1_3_2","first-page":"137","article-title":"Maternal genes: mitochondrial diseases","volume":"23","author":"Wallace DC","year":"1987","journal-title":"Birth Defects"},{"key":"e_1_2_1_4_2","volume-title":"Symbiosis in Cell Evolution","author":"Margulis L","year":"1981"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02928005"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02881107"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1139\/o88-042"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1099\/00221287-71-1-35"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-66856-2_6"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-3002(60)91207-5"},{"key":"e_1_2_1_11_2","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/0926-6550(63)90356-6","article-title":"Protein synthesis in heart mitochondria","volume":"72","author":"Kroon AM","year":"1963","journal-title":"Biochim Biophys Acta"},{"key":"e_1_2_1_12_2","first-page":"409","article-title":"Protein synthese in isolierten hefe\u2010mitochondrien","volume":"341","author":"Wintersberger E","year":"1965","journal-title":"Biochem Z"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1099\/00221287-67-2-175"},{"key":"e_1_2_1_14_2","doi-asserted-by":"crossref","first-page":"4063","DOI":"10.1016\/S0021-9258(19)45139-9","article-title":"Effects of chloramphenicol and cycloheximide on the synthesis of mitochondrial ribosomes in Tetrahymena","volume":"247","author":"Millis AJT","year":"1972","journal-title":"J Biol Chem"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1550-7408.1973.tb00915.x"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.1040850108"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01277047"},{"key":"e_1_2_1_18_2","doi-asserted-by":"crossref","first-page":"2192","DOI":"10.1016\/S0021-9258(18)93462-9","article-title":"Impaired binding of mitochondrial ATPase in the cytoplasmic \u201cpetite\u201d m utant of Saccharomyces cerevisiae","volume":"243","author":"Schatz G","year":"1968","journal-title":"J Biol Chem"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/0005-2728(68)90143-6"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1099\/00221287-67-2-161"},{"key":"e_1_2_1_21_2","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1242\/jcs.61.1.437","article-title":"Mitochondria of Tetrahymena pyriformis: Enumeration and sizing of isolated organelles using a Coulter Counter and pulse\u2010height analyser","volume":"61","author":"Poole RK","year":"1983","journal-title":"J Cell Sci"},{"key":"e_1_2_1_22_2","first-page":"245","volume-title":"International Cell Biology 1976\u20131977","author":"O'Brien TW","year":"1977"},{"key":"e_1_2_1_23_2","first-page":"99","article-title":"Mode of action of antibiotics on various steps of protein synthesis","volume":"1","author":"Kaji A","year":"1971","journal-title":"Adv Cytopharmacol"},{"key":"e_1_2_1_24_2","first-page":"51","article-title":"Croissance des cultures et morphologie des mitochondries chez des mutants \u00e0 h\u00e9r\u00e9dit\u00e9 cytoplasmique, r\u00e9sistance au chloramph\u00e9nicol, de Tetrahymena pyriformis","volume":"37","author":"Curgy JJ","year":"1980","journal-title":"Biol Cell"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.54.1.8"},{"key":"e_1_2_1_26_2","doi-asserted-by":"publisher","DOI":"10.1099\/00221287-61-1-33"},{"key":"e_1_2_1_27_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01281784"},{"key":"e_1_2_1_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/0065-2571(80)90007-2"},{"key":"e_1_2_1_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/0378-5173(80)90102-7"},{"key":"e_1_2_1_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/0306-3623(85)90145-4"},{"key":"e_1_2_1_31_2","first-page":"279","article-title":"Modifications des mitochondries et synth\u00e8se de l'ADN mitochondrial de Tetrahymena pyriformis apres action du bromure d'ethidium","volume":"14","author":"Charret R","year":"1972","journal-title":"J Microsc"},{"key":"e_1_2_1_32_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1550-7408.1974.tb03712.x"},{"key":"e_1_2_1_33_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00333866"},{"key":"e_1_2_1_34_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00420726"},{"key":"e_1_2_1_35_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1550-7408.1964.tb01734.x"},{"key":"e_1_2_1_36_2","doi-asserted-by":"publisher","DOI":"10.1038\/2071280a0"},{"key":"e_1_2_1_37_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.37.3.660"},{"key":"e_1_2_1_38_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1550-7408.1964.tb01739.x"},{"key":"e_1_2_1_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(70)90280-7"},{"key":"e_1_2_1_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5320(72)90122-0"},{"key":"e_1_2_1_41_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.34.1.1"},{"key":"e_1_2_1_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/0005-2787(68)90119-6"},{"key":"e_1_2_1_43_2","doi-asserted-by":"publisher","DOI":"10.1099\/00221287-91-1-150"},{"key":"e_1_2_1_44_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0016672300010934"},{"key":"e_1_2_1_45_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0016672300011174"},{"key":"e_1_2_1_46_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.67.1.52"},{"key":"e_1_2_1_47_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00433106"},{"key":"e_1_2_1_48_2","doi-asserted-by":"publisher","DOI":"10.1016\/0027-5107(71)90086-8"},{"key":"e_1_2_1_49_2","doi-asserted-by":"publisher","DOI":"10.1016\/0968-0004(79)90079-3"},{"key":"e_1_2_1_50_2","doi-asserted-by":"publisher","DOI":"10.1016\/0968-0004(82)90186-4"},{"key":"e_1_2_1_51_2","doi-asserted-by":"publisher","DOI":"10.1038\/166956a0"},{"key":"e_1_2_1_52_2","volume-title":"Nucleocytoplasmic Relations in Micro\u2010Organisms","author":"Ephrussi B","year":"1953"},{"key":"e_1_2_1_53_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-291X(68)90440-3"},{"key":"e_1_2_1_54_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00433228"},{"key":"e_1_2_1_55_2","first-page":"181","volume-title":"Molecular Cytogenetics","author":"Mahler HR","year":"1973"},{"key":"e_1_2_1_56_2","doi-asserted-by":"publisher","DOI":"10.1002\/jss.400010602"},{"key":"e_1_2_1_57_2","first-page":"6617","article-title":"Molecular mechanisms of mitochondrial genetic activity. Effects of ethidium bromide on the deoxyribonucleic acid and energetics of isolated mitochondria","volume":"249","author":"Bastos RN","year":"1974","journal-title":"J Biol Chem"},{"key":"e_1_2_1_58_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.71.6.2241"},{"key":"e_1_2_1_59_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00331451"},{"key":"e_1_2_1_60_2","doi-asserted-by":"publisher","DOI":"10.1016\/0165-1218(84)90056-9"},{"key":"e_1_2_1_61_2","doi-asserted-by":"publisher","DOI":"10.1016\/0165-1218(87)90038-3"},{"key":"e_1_2_1_62_2","first-page":"275","volume-title":"Antibiotics V\/2","author":"Gniazdowski M","year":"1978"},{"key":"e_1_2_1_63_2","first-page":"5646","article-title":"Induction de la mutation \u201cpepite colonie\u201d c hez la Levure par le 5\u2010fluorouracile","volume":"256","author":"Moustacchi E","year":"1963","journal-title":"C R Acad Sci Paris"},{"key":"e_1_2_1_64_2","first-page":"27","article-title":"Action of 4\u2010Nitroquinoline\u2010N\u2010oxide on mitochondrial DNA in yeast","volume":"65","author":"Morita T","year":"1974","journal-title":"GANN"},{"key":"e_1_2_1_65_2","doi-asserted-by":"publisher","DOI":"10.1099\/00221287-83-2-283"},{"key":"e_1_2_1_66_2","first-page":"99","article-title":"Effects of adriamycin on the mitochondria of Saccharomyces cerevisiae","volume":"6","author":"Evans IH","year":"1980","journal-title":"Proc Soc Gen Microbiol"},{"key":"e_1_2_1_67_2","first-page":"35","article-title":"Primary antimitochondrial activity of the cancer drug methylglyoxal bis (guanylhydrazone) in yeast cells","volume":"119","author":"Diala ES","year":"1980","journal-title":"J Gen Microbiol"},{"key":"e_1_2_1_68_2","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1980.209"},{"key":"e_1_2_1_69_2","doi-asserted-by":"publisher","DOI":"10.1248\/cpb.22.2258"},{"key":"e_1_2_1_70_2","doi-asserted-by":"publisher","DOI":"10.1016\/0027-5107(80)90070-6"},{"key":"e_1_2_1_71_2","doi-asserted-by":"publisher","DOI":"10.1016\/0005-2787(72)90092-5"},{"key":"e_1_2_1_72_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-230X(08)60545-X"},{"key":"e_1_2_1_73_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-6968.1982.tb00057.x"},{"key":"e_1_2_1_74_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00333482"},{"key":"e_1_2_1_75_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(71)90045-1"},{"key":"e_1_2_1_76_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(73)90169-X"},{"key":"e_1_2_1_77_2","first-page":"31","volume-title":"Plant Senescence: Its Biochemistry and Physiology","author":"Cummings DJ","year":"1987"},{"key":"e_1_2_1_78_2","first-page":"505","article-title":"Life\u2010span and senescence in Podospora anserina: Effect of mitochondrial genes and functions","volume":"119","author":"Belcour L","year":"1980","journal-title":"J Gen Microbiol"},{"key":"e_1_2_1_79_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00267692"},{"key":"e_1_2_1_80_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00420231"},{"key":"e_1_2_1_81_2","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1242\/jcs.7.2.501","article-title":"Chloramphenicol\u2010related changes in mitochondrial ultrastructure","volume":"7","author":"Smith U","year":"1970","journal-title":"J Cell Sci"},{"key":"e_1_2_1_82_2","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1242\/jcs.41.1.291","article-title":"Biochemical and ultrastructural studies on flight muscle mitochondria from the blowfly Calliphora erythrocephala following treatment by chloramphenicol and ethidium bromide","volume":"41","author":"Ashour B","year":"1980","journal-title":"J Cell Sci"},{"key":"e_1_2_1_83_2","doi-asserted-by":"publisher","DOI":"10.1016\/0005-2787(77)90051-X"},{"key":"e_1_2_1_84_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.53.1.127"},{"key":"e_1_2_1_85_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.67.1.174"},{"key":"e_1_2_1_86_2","first-page":"601","article-title":"Chloramphenicol induced mitochondrial and ultrastructural changes in hemopoietic cells","volume":"100","author":"Skinnider LF","year":"1976","journal-title":"Arch Pathol Lab Med"},{"key":"e_1_2_1_87_2","doi-asserted-by":"publisher","DOI":"10.1002\/jmr.300010105"},{"key":"e_1_2_1_88_2","doi-asserted-by":"publisher","DOI":"10.1038\/314592a0"},{"key":"e_1_2_1_89_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-291X(68)90674-8"},{"key":"e_1_2_1_90_2","first-page":"176","article-title":"Detection of primary antimitochondrial activity of drugs in cultured mammalian cells utilizing glutamine as the carbon source","volume":"52","author":"Patel R","year":"1984","journal-title":"Exp Cell Biol"},{"key":"e_1_2_1_91_2","first-page":"37","article-title":"The effect of 5\u2010fluorouracil, ethidium bromide and chloramphenicol on some mitochondrial functions in regenerating rat liver","volume":"21","author":"Krempask\u00fd V","year":"1974","journal-title":"Neoplasma"},{"key":"e_1_2_1_92_2","first-page":"119","article-title":"The yeast cell in the antimitochondrial activity of drugs","volume":"22","author":"Wilkie D","year":"1972","journal-title":"Med Biol Illust"},{"key":"e_1_2_1_93_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.bi.54.070185.003313"},{"key":"e_1_2_1_94_2","doi-asserted-by":"crossref","first-page":"9352","DOI":"10.1016\/S0021-9258(19)83522-6","article-title":"Mitochondria contain a distinct DNA topoisomerase","volume":"254","author":"Fairfield FR","year":"1979","journal-title":"J Biol Chem"},{"key":"e_1_2_1_95_2","doi-asserted-by":"crossref","first-page":"11193","DOI":"10.1016\/S0021-9258(19)86467-0","article-title":"Search for a DNA gyrase in mammalian mitochondria","volume":"254","author":"Castora FJ","year":"1979","journal-title":"J Biol Chem"},{"key":"e_1_2_1_96_2","doi-asserted-by":"publisher","DOI":"10.1016\/0167-4781(83)90090-8"},{"key":"e_1_2_1_97_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-291X(85)90495-4"},{"key":"e_1_2_1_98_2","doi-asserted-by":"publisher","DOI":"10.1016\/0005-2787(79)90049-2"},{"key":"e_1_2_1_99_2","doi-asserted-by":"publisher","DOI":"10.1038\/286529a0"},{"key":"e_1_2_1_100_2","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/6.9.1343"},{"key":"e_1_2_1_101_2","doi-asserted-by":"crossref","first-page":"8604","DOI":"10.1016\/S0021-9258(19)84422-8","article-title":"Effect of bacterial DNA gyrase inhibitors, novobiocin, nalidixic acid, and oxolinic acid, on oxidative phosphorylation","volume":"261","author":"Gallagher M","year":"1986","journal-title":"J Biol Chem"},{"key":"e_1_2_1_102_2","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/8.11.1613"},{"key":"e_1_2_1_103_2","doi-asserted-by":"publisher","DOI":"10.1016\/0167-4781(84)90080-0"},{"key":"e_1_2_1_104_2","doi-asserted-by":"publisher","DOI":"10.1093\/mutage\/2.3.179"},{"key":"e_1_2_1_105_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.81.5.1361"},{"key":"e_1_2_1_106_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(85)90273-4"},{"key":"e_1_2_1_107_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.32.8.1182"},{"key":"e_1_2_1_108_2","first-page":"104","volume-title":"Psychopharmacological agents, Vol. II","author":"Gordon MM","year":"1967"},{"key":"e_1_2_1_109_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0074-7742(08)60138-5"},{"key":"e_1_2_1_110_2","first-page":"583","article-title":"The membrane actions of anesthetics and tranquilizers","volume":"24","author":"Seeman P","year":"1972","journal-title":"Pharmacol Rev"},{"key":"e_1_2_1_111_2","doi-asserted-by":"publisher","DOI":"10.1016\/0005-2736(72)90023-5"},{"key":"e_1_2_1_112_2","doi-asserted-by":"publisher","DOI":"10.1139\/y74-070"},{"key":"e_1_2_1_113_2","first-page":"155","volume-title":"Mechanisms in Bioenergetics","author":"Racker E","year":"1965"},{"key":"e_1_2_1_114_2","first-page":"857","article-title":"Non\u2010steroidal anti\u2010inflammatory effect on mitochondrial reactions","volume":"10","author":"Shiojiri H","year":"1984","journal-title":"Drugs Exp Clin Res"},{"key":"e_1_2_1_115_2","doi-asserted-by":"publisher","DOI":"10.1042\/bj0720462"},{"key":"e_1_2_1_116_2","doi-asserted-by":"publisher","DOI":"10.1038\/201629a0"},{"key":"e_1_2_1_117_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(67)90065-2"},{"key":"e_1_2_1_118_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(75)90125-2"},{"key":"e_1_2_1_119_2","doi-asserted-by":"publisher","DOI":"10.1016\/0028-3908(79)90013-3"},{"key":"e_1_2_1_120_2","doi-asserted-by":"publisher","DOI":"10.1016\/0028-3908(79)90014-5"},{"key":"e_1_2_1_121_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1975.tb41546.x"},{"key":"e_1_2_1_122_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00241732"},{"key":"e_1_2_1_123_2","first-page":"153","volume-title":"Cellular and Molecular Neurotoxicology","author":"Silbergeld EK","year":"1984"},{"key":"e_1_2_1_124_2","unstructured":"MartelJ MarionM DenizeauF:Involvement of mitochondria in the cellular mechanisms of cadmium toxicity in rat hepatocytes. Abstracts of the 4thInternational Congress of Cell Biology Montreal 1988 No 433."},{"key":"e_1_2_1_125_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI107015"},{"key":"e_1_2_1_126_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.30.2.269"},{"key":"e_1_2_1_127_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.59.2.624"},{"key":"e_1_2_1_128_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-291X(77)91233-5"},{"key":"e_1_2_1_129_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/7.6.593"},{"key":"e_1_2_1_130_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/12.6.535"},{"key":"e_1_2_1_131_2","first-page":"927","article-title":"Chloramphenicol and bone marrow mitochondria","volume":"74","author":"Martelo OJ","year":"1969","journal-title":"J Lab Clin Med"},{"key":"e_1_2_1_132_2","first-page":"157","article-title":"On the protection of bone marrow against toxic side effects of tetracyclines","volume":"3","author":"Gijzel WP","year":"1978","journal-title":"J Mol Med"},{"key":"e_1_2_1_133_2","first-page":"334","article-title":"Versuche an \u00dcberlenbendem Carcinomcrebe Atmung und Glycolyse","volume":"142","author":"Minami S","year":"1923","journal-title":"Biochem Z"},{"key":"e_1_2_1_134_2","doi-asserted-by":"publisher","DOI":"10.1159\/000401202"},{"key":"e_1_2_1_135_2","first-page":"1943","article-title":"Arrest of in vivo proliferation of Zajdela tumor cells by inhibition of mitochondrial protein synthesis","volume":"41","author":"Van den Bogert C","year":"1981","journal-title":"Cancer Res"},{"key":"e_1_2_1_136_2","first-page":"2247","article-title":"Arrest of in vivo growth of a solid Leyding cell tumor by prolonged inhibition of mitochondrial protein synthesis","volume":"43","author":"Van den Bogert C","year":"1983","journal-title":"Cancer Res"},{"key":"e_1_2_1_137_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3835(84)80023-3"},{"key":"e_1_2_1_138_2","doi-asserted-by":"publisher","DOI":"10.1016\/0145-2126(87)90088-9"},{"key":"e_1_2_1_139_2","first-page":"651","article-title":"Energy deprivation of Zajdela hepatoma cells upon in vivo treatment with thiamphenicol","volume":"30","author":"Ku\u017eela \u0160","year":"1983","journal-title":"Neoplasma"},{"key":"e_1_2_1_140_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.6623064"},{"key":"e_1_2_1_141_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.83.24.9729"},{"key":"e_1_2_1_142_2","first-page":"777","article-title":"Bleomycin\u2010induced fine structural alterations in cultured mouse fibroblasts and human lymphocytes of neoplastic origin","volume":"33","author":"Krishan A","year":"1973","journal-title":"Cancer Res"},{"key":"e_1_2_1_143_2","first-page":"3574","article-title":"Effects of bleomycin on human tongue carcinoma cells as revealed by electron microscopy","volume":"36","author":"Yasuzumi G","year":"1976","journal-title":"Cancer Res"},{"key":"e_1_2_1_144_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00284742"},{"key":"e_1_2_1_145_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(87)90263-2"},{"key":"e_1_2_1_146_2","first-page":"50","volume-title":"Accomplishments in Cancer Research","author":"Rosenberg B","year":"1984"},{"key":"e_1_2_1_147_2","unstructured":"SinghG Maniccia\u2010BozzoE:Regulation of mitochondrial DNA in mouse liver and kidney following cisdichlorodiamineplatinum treatment. Abstracts of the 4thInternational Congress of Cell Biology Montreal 1988 No 337."},{"key":"e_1_2_1_148_2","unstructured":"SzekelyJG LobreauAU RaaphorstGP:Morphological response of the human T\u2010lymphocyte line MOLT\u20104 to the anti\u2010cancer drug Lodinamine. Abstracts of the 4thInternational Congress of Cell Biology Montreal 1988 No 338."},{"key":"e_1_2_1_149_2","first-page":"766","volume-title":"Handbook of Experimental Pharmacology, Vol. 38\/2","author":"Mihich E","year":"1975"},{"key":"e_1_2_1_150_2","first-page":"2246","article-title":"Morphological evidence for an antimitochondrial action by methylglyoxal\u2010bis(guanylhydrazone)","volume":"37","author":"Pathak SN","year":"1977","journal-title":"Cancer Res"},{"key":"e_1_2_1_151_2","first-page":"1919","article-title":"The generality of methylglyoxal bis (guanylhydrazone) induced mitochondrial damage and the dependence of this effect on cell proliferation","volume":"39","author":"Mikles\u2010Robertson F","year":"1979","journal-title":"Cancer Res"},{"key":"e_1_2_1_152_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-291X(79)90865-9"},{"key":"e_1_2_1_153_2","doi-asserted-by":"publisher","DOI":"10.1038\/274209a0"},{"key":"e_1_2_1_154_2","doi-asserted-by":"publisher","DOI":"10.1038\/202781a0"},{"key":"e_1_2_1_155_2","doi-asserted-by":"publisher","DOI":"10.1042\/bj1180099"},{"key":"e_1_2_1_156_2","doi-asserted-by":"publisher","DOI":"10.1016\/0009-2797(72)90001-4"},{"key":"e_1_2_1_157_2","doi-asserted-by":"publisher","DOI":"10.1038\/287244a0"},{"key":"e_1_2_1_158_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.6770466"},{"key":"e_1_2_1_159_2","first-page":"95","article-title":"Benzo[a]pyrene differentially alters mitochondrial and nuclear DNA synthesis in primary hepatocyte cultures","volume":"42","author":"Stairs PW","year":"1983","journal-title":"Res Commun Chem Pathol Pharmacol"},{"key":"e_1_2_1_160_2","doi-asserted-by":"publisher","DOI":"10.1016\/0378-4274(84)90071-7"},{"key":"e_1_2_1_161_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.6797067"},{"key":"e_1_2_1_162_2","doi-asserted-by":"publisher","DOI":"10.1254\/jjp.24.535"},{"key":"e_1_2_1_163_2","doi-asserted-by":"publisher","DOI":"10.7164\/antibiotics.24.835"},{"key":"e_1_2_1_164_2","doi-asserted-by":"publisher","DOI":"10.1021\/bi00695a022"},{"key":"e_1_2_1_165_2","doi-asserted-by":"publisher","DOI":"10.7164\/antibiotics.28.809"},{"key":"e_1_2_1_166_2","unstructured":"FriedmanMA HigginsES:Inhibition of mitochondrial respiration in mouse liver by unmetabolized dimethylnitrosoamine. Abstract of the Proc Am Assoc Cancer Res1976 No 26."},{"key":"e_1_2_1_167_2","doi-asserted-by":"publisher","DOI":"10.1016\/0009-2797(77)90095-3"},{"key":"e_1_2_1_168_2","doi-asserted-by":"publisher","DOI":"10.1016\/0165-1110(87)90028-5"},{"key":"e_1_2_1_169_2","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(88)81018-4"},{"key":"e_1_2_1_170_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(77)90286-0"},{"key":"e_1_2_1_171_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-291X(88)81207-5"},{"key":"e_1_2_1_172_2","first-page":"1141","article-title":"Role of superoxide dismutase in cancer: A review","volume":"39","author":"Oberley LW","year":"1979","journal-title":"Cancer Res"},{"key":"e_1_2_1_173_2","doi-asserted-by":"publisher","DOI":"10.3181\/00379727-69-16691"},{"key":"e_1_2_1_174_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00602008"},{"key":"e_1_2_1_175_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00602215"},{"key":"e_1_2_1_176_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02896876"},{"key":"e_1_2_1_177_2","first-page":"61","article-title":"Furan derivatives\u2014their common molecular denominator responsible for bleaching of Euglena gracilis","volume":"57","author":"Ebringer L","year":"1967","journal-title":"Arch Microbiol"},{"key":"e_1_2_1_178_2","doi-asserted-by":"publisher","DOI":"10.1099\/00221287-59-2-203"},{"key":"e_1_2_1_179_2","first-page":"229","article-title":"Mitomycins and the bleaching of Euglena gracilis","volume":"64","author":"Ebringer L","year":"1969","journal-title":"Arch Microbiol"},{"key":"e_1_2_1_180_2","first-page":"268","article-title":"Changes of the plastid system of Euglena gracilis induced with streptomycin and dihydrostreptomycin","volume":"73","author":"Ebringer L","year":"1970","journal-title":"Arch Microbiol"},{"key":"e_1_2_1_181_2","first-page":"873","volume-title":"Advances in Antimicrobial and Antineoplastic Chemotherapy, Vol. 1","author":"Ebringer L","year":"1972"},{"key":"e_1_2_1_182_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.9.4.682"},{"key":"e_1_2_1_183_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.137.3525.225"},{"key":"e_1_2_1_184_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1550-7408.1965.tb01808.x"},{"key":"e_1_2_1_185_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2836(64)80060-7"},{"key":"e_1_2_1_186_2","doi-asserted-by":"publisher","DOI":"10.1093\/jxb\/24.2.361"},{"key":"e_1_2_1_187_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1550-7408.1967.tb01995.x"},{"key":"e_1_2_1_188_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-291X(67)90523-2"},{"key":"e_1_2_1_189_2","first-page":"113","article-title":"Comparison of the effects of 7\u2010halo\u2010derivatives of lincomycin on Euglena gracilis","volume":"5","author":"Ebringer L","year":"1976","journal-title":"Acta F R N Univ Comen\u2010Microbiol"},{"key":"e_1_2_1_190_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00015819"},{"key":"e_1_2_1_191_2","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(89)80490-9"},{"key":"e_1_2_1_192_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.33.11.1883"},{"key":"e_1_2_1_193_2","first-page":"61","article-title":"Injured mitochondria in cells of Euglena gracilis after DNA gyrase inhibitors treatment","volume":"104","author":"Pol\u00f3nyi J","year":"1990","journal-title":"Z Mikrosk Anat Forschung"},{"key":"e_1_2_1_194_2","doi-asserted-by":"publisher","DOI":"10.1159\/000238601"},{"key":"e_1_2_1_195_2","first-page":"61","article-title":"The effect of elevated temperature on the mutagenicity of nitrovin in Euglena gracilis","volume":"13","author":"Chre\u00f1o O","year":"1984","journal-title":"Acta F R N Univ Comen\u2010Microbiol"},{"key":"e_1_2_1_196_2","doi-asserted-by":"publisher","DOI":"10.1002\/tcm.1770050503"},{"key":"e_1_2_1_197_2","doi-asserted-by":"publisher","DOI":"10.1002\/tcm.1770080305"},{"key":"e_1_2_1_198_2","first-page":"236","article-title":"The study of correlation between in vivo and in vitro toxicity","volume":"16","author":"Vrbovsk\u00fd L","year":"1975","journal-title":"Proc Eur Soc Toxicol"},{"key":"e_1_2_1_199_2","first-page":"499","article-title":"Trace metals and neoplasia","volume":"4","author":"Sky\u2010Peck HH","year":"1986","journal-title":"Clin Physiol Biochem"},{"key":"e_1_2_1_200_2","doi-asserted-by":"publisher","DOI":"10.1016\/0300-483X(82)90050-6"},{"key":"e_1_2_1_201_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(84)90718-4"},{"key":"e_1_2_1_202_2","doi-asserted-by":"publisher","DOI":"10.1021\/tx00002a003"},{"key":"e_1_2_1_203_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(17)38476-4"},{"key":"e_1_2_1_204_2","doi-asserted-by":"publisher","DOI":"10.1016\/0013-9351(85)90107-0"},{"key":"e_1_2_1_205_2","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9861(89)90550-X"},{"key":"e_1_2_1_206_2","doi-asserted-by":"publisher","DOI":"10.1080\/00028897708984403"},{"key":"e_1_2_1_207_2","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/10.6.1139"},{"key":"e_1_2_1_208_2","first-page":"133","article-title":"Covalent binding of benzene and its metabolites to DNA of rabbit bone marrow mitochondria in vitro","volume":"49","author":"Rushmore T","year":"1987","journal-title":"Chem Biol Interact"},{"key":"e_1_2_1_209_2","volume-title":"Metabolismus of Tumors","author":"Warburg O","year":"1930"},{"key":"e_1_2_1_210_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.6770466"},{"key":"e_1_2_1_211_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/17.13.5191"},{"key":"e_1_2_1_212_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.3201231"},{"key":"e_1_2_1_213_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-291X(88)90272-0"},{"key":"e_1_2_1_214_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00572761"},{"key":"e_1_2_1_215_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0404.1984.tb02423.x"},{"key":"e_1_2_1_216_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00277689"},{"key":"e_1_2_1_217_2","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1542\/peds.64.1.24","article-title":"An X\u2010linked recessive cardiomyopathy with abnormal mitochondria","volume":"64","author":"Neustein HB","year":"1979","journal-title":"Pediatrics"},{"key":"e_1_2_1_218_2","doi-asserted-by":"crossref","unstructured":"FinePEM: Mitochondrial inheritance and disease.Lancet ii:659\u2013662 1978.","DOI":"10.1016\/S0140-6736(78)92764-2"},{"key":"e_1_2_1_219_2","doi-asserted-by":"publisher","DOI":"10.1016\/0168-9525(89)90005-X"},{"key":"e_1_2_1_220_2","first-page":"155","article-title":"Nickel\u2010induced alterations in mitochondria: CTEM and EELS studies in the house cricket testis","volume":"57","author":"Kihn Y","year":"1989","journal-title":"Cytobios"},{"key":"e_1_2_1_221_2","first-page":"345","article-title":"Cardiovasculaar actions of nickel ions","volume":"55","author":"Rub\u00e1nyi G","year":"1980","journal-title":"Acta Physiol Acad Sci Hung"},{"key":"e_1_2_1_222_2","first-page":"229","article-title":"Increased lipid peroxidation in tissues of nickel\u2010chloride\u2010treated rats","volume":"15","author":"Sunderman FW","year":"1985","journal-title":"Ann Clin Lab Sci"},{"key":"e_1_2_1_223_2","first-page":"102","article-title":"Cancers of the lung and nasal sinuses in nickel workers: a reassessment of the period of risk","volume":"34","author":"Doll R","year":"1977","journal-title":"Br J Ind Med"},{"key":"e_1_2_1_224_2","doi-asserted-by":"publisher","DOI":"10.1021\/bi00418a015"},{"issue":"5","key":"e_1_2_1_225_2","first-page":"971","article-title":"Correlation between antibacterial and antichloroplastic activity of new quinolones","volume":"11","author":"Kraj\u010dovi\u010d J","year":"1989","journal-title":"Rev Infect Dis"}],"container-title":["Teratogenesis, Carcinogenesis, and Mutagenesis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Ftcm.1770100606","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/tcm.1770100606","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,22]],"date-time":"2023-10-22T17:06:53Z","timestamp":1697994413000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/tcm.1770100606"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1990,1]]},"references-count":224,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1990,1]]}},"alternative-id":["10.1002\/tcm.1770100606"],"URL":"https:\/\/doi.org\/10.1002\/tcm.1770100606","archive":["Portico"],"relation":{},"ISSN":["0270-3211","1520-6866"],"issn-type":[{"value":"0270-3211","type":"print"},{"value":"1520-6866","type":"electronic"}],"subject":[],"published":{"date-parts":[[1990,1]]}}}