{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T13:34:28Z","timestamp":1790775268081,"version":"4.1.0"},"reference-count":20,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2005,9,9]],"date-time":"2005-09-09T00:00:00Z","timestamp":1126224000000},"content-version":"vor","delay-in-days":5365,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Teratog Carcinog Mutagen"],"published-print":{"date-parts":[[1991,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>C57BL\/6J mice were used to study the ocular teratogenic effects of cyclophosphamide administered to pregnant females on d 9 of pregnancy at a dose of 5 mg\/kg body weight. Nile blue staining demonstrated increased cell death at the base of the optic stalk, in the optic vesicle, and in the perivesicular mesenchyme in treated embryos. Malformations studied at gestational d 11 and 16 by light and scanning electron microscopy included microphthalmos, microphakia, and aphakia and were predictable based upon patterns of increased cell death. These anomalies are similar to those reported with exposure to ethanol or isotretinoin on gestational d 7.<\/jats:p>","DOI":"10.1002\/tcm.1770110405","type":"journal-article","created":{"date-parts":[[2006,2,4]],"date-time":"2006-02-04T12:48:29Z","timestamp":1139057309000},"page":"203-212","source":"Crossref","is-referenced-by-count":15,"title":["Relationship of cell death to cyclophosphamide\u2010induced ocular malformations"],"prefix":"10.1002","volume":"11","author":[{"given":"Robert L.","family":"Peiffer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"McCullen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ajit J.","family":"Alles","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathleen K.","family":"Sulik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,9,9]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/jmor.1051400204"},{"key":"e_1_2_1_3_2","first-page":"276","volume-title":"Pharmacologic Principles of Cancer Treatment","author":"Colvin M","year":"1983"},{"key":"e_1_2_1_4_2","first-page":"651","article-title":"Studies related to the mechanism of action of cytotoxic alkylating agents: a review","volume":"22","author":"Wheeler GP","year":"1962","journal-title":"Cancer Res"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/tcm.1770050202"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/tcm.1770090403"},{"key":"e_1_2_1_7_2","first-page":"475","article-title":"The teratogenicity of cyclophosphamide in mice","volume":"28","author":"Gibson JE","year":"1968","journal-title":"Cancer Res"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/tcm.1770080403"},{"key":"e_1_2_1_9_2","first-page":"1344","article-title":"Genese des anomalies primaries de la cupule optique de l'embroyon de lapin sous l'action du cyclophosphamide","volume":"164","author":"Clavert A","year":"1970","journal-title":"CR Soc Biol (Paris)"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1159\/000144581"},{"key":"e_1_2_1_11_2","first-page":"684","article-title":"Histological study of eye malformations induced by cyclophosphamide in rat fetuses","volume":"79","author":"Singh S","year":"1984","journal-title":"Indian J Med Res"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1159\/000144581"},{"key":"e_1_2_1_13_2","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1111\/j.1469-185X.1951.tb00774.x","article-title":"Cell death in normal vertebrate ontogeny","volume":"26","author":"Glucksmann A","year":"1951","journal-title":"Biol Rev"},{"key":"e_1_2_1_14_2","first-page":"213","article-title":"Teratogens and craniofacial malformations in relationship to cell death development","volume":"103","author":"Sulik KK","year":"1988","journal-title":"Development (Suppl)"},{"key":"e_1_2_1_15_2","first-page":"169","volume-title":"Advances in Teratology","author":"Menkes B","year":"1970"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/jez.1401660104"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420020408"},{"key":"e_1_2_1_18_2","first-page":"1215","article-title":"Sequential scanning electron microscopy analyses of normal and spontaneously occurring abnormal ocular development in C57B1\/6J mice","volume":"3","author":"Cook CS","year":"1986","journal-title":"Scanning Electron Microsc"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420420504"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1987.01060110122045"},{"key":"e_1_2_1_21_2","doi-asserted-by":"crossref","first-page":"60","DOI":"10.3928\/0191-3913-19880301-04","article-title":"Keratolenticular dysgenesis (Peters anomaly) as result of acute embryonic insult during gastruation","volume":"25","author":"Cook CS","year":"1988","journal-title":"J Pediatr Ophthalmol Strabismus"}],"container-title":["Teratogenesis, Carcinogenesis, and Mutagenesis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Ftcm.1770110405","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/tcm.1770110405","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,23]],"date-time":"2023-10-23T05:12:31Z","timestamp":1698037951000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/tcm.1770110405"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1991,1]]},"references-count":20,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1991,1]]}},"alternative-id":["10.1002\/tcm.1770110405"],"URL":"https:\/\/doi.org\/10.1002\/tcm.1770110405","archive":["Portico"],"relation":{},"ISSN":["0270-3211","1520-6866"],"issn-type":[{"value":"0270-3211","type":"print"},{"value":"1520-6866","type":"electronic"}],"subject":[],"published":{"date-parts":[[1991,1]]}}}