{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T13:24:19Z","timestamp":1768397059512,"version":"3.49.0"},"reference-count":23,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2005,9,9]],"date-time":"2005-09-09T00:00:00Z","timestamp":1126224000000},"content-version":"vor","delay-in-days":5000,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Teratog Carcinog Mutagen"],"published-print":{"date-parts":[[1992,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Guinea pigs were exposed to hyperthermia for 1 hr once or twice on day 11, 12, 13, or 14 (E11\u2013E14) of pregnancy. The mean rectal temperatures were elevated by 3.4\u00b0C\u20134.0\u00b0C. This treatment resulted in a marked elevation of rates of resorption and developmental defects in embryos examined at day E23. The defects observed were those affecting the neural tube (NTD) (exencephaly, encephaloceles, and microphthalmia), kyphosis\/scoliosis, branchial arch defects, and pericardial edema. Embryos with NTD and kyphosis\/scoliosis have not been found among newborn guinea pigs to date following maternal heat exposure on days E12\u2013E14. It appears that embryos with these defects are filtered out by resorption or abortion by days E30\u2013E35. \u00a9 1992 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/tcm.1770120102","type":"journal-article","created":{"date-parts":[[2006,2,4]],"date-time":"2006-02-04T12:25:56Z","timestamp":1139055956000},"page":"1-9","source":"Crossref","is-referenced-by-count":22,"title":["Neural tube and other developmental anomalies in the guinea pig following maternal hyperthermia during early neural tube development"],"prefix":"10.1002","volume":"12","author":[{"given":"Judith","family":"Cawdell\u2010Smith","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey","family":"Upfold","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marshall","family":"Edwards","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Murray","family":"Smith","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,9,9]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420020407"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.humrep.a137250"},{"key":"e_1_2_1_4_2","first-page":"349","volume-title":"Ageing Gametes","author":"Nishimura H","year":"1975"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420310109"},{"key":"e_1_2_1_6_2","volume-title":"Proc DW Smith Conference","author":"Chernoff GF","year":"1985"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420010206"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420290313"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420140307"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420390209"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420170306"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420320214"},{"key":"e_1_2_1_13_2","volume-title":"Proc Greenwood Genetic Center","author":"Chernoff GF","year":"1983"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01900945"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420430106"},{"key":"e_1_2_1_16_2","first-page":"764","article-title":"Hyperthermia and meningomyelocele and anencephaly","volume":"1","author":"Chance PF","year":"1978","journal-title":"Lancet"},{"key":"e_1_2_1_17_2","first-page":"116A","article-title":"Hyperthermia as a possible cause of occipital encephalocele","volume":"28","author":"Fisher NL","year":"1980","journal-title":"West Soc Pediatr Res"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(78)91957-8"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420210114"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(78)90549-4"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320120306"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420330316"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420250307"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420310212"}],"container-title":["Teratogenesis, Carcinogenesis, and Mutagenesis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Ftcm.1770120102","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/tcm.1770120102","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,24]],"date-time":"2023-10-24T00:45:02Z","timestamp":1698108302000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/tcm.1770120102"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1992,1]]},"references-count":23,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1992,1]]}},"alternative-id":["10.1002\/tcm.1770120102"],"URL":"https:\/\/doi.org\/10.1002\/tcm.1770120102","archive":["Portico"],"relation":{},"ISSN":["0270-3211","1520-6866"],"issn-type":[{"value":"0270-3211","type":"print"},{"value":"1520-6866","type":"electronic"}],"subject":[],"published":{"date-parts":[[1992,1]]}}}