{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T05:18:12Z","timestamp":1761196692931},"reference-count":20,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2005,9,9]],"date-time":"2005-09-09T00:00:00Z","timestamp":1126224000000},"content-version":"vor","delay-in-days":5000,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Teratog Carcinog Mutagen"],"published-print":{"date-parts":[[1992,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Effects of dietary bile acids and their sodium salts on the development of pepsinogen\u2010altered pyloric glands (PAPG) were examined in male WKY\/N Crj rats initially given a single dose of 160 mg\/kg body weight of <jats:italic>N<\/jats:italic>\u2010methyl\u2010<jats:italic>N<\/jats:italic>\u2032\u2010nitro\u2010<jats:italic>N<\/jats:italic>\u2010nitrosoguanidine (MNNG) by gastric intubation. From week 3 the animals were administered basal diet containing 0.5% supplements of cholic acid (CA), deoxycholic acid (DCA), chenodeoxycholic acid (CDCA) or their sodium salts (Na\u2010C, Na\u2010DC and Na\u2010CDC), or 5% ascorbic acid (ASA) or its salt (Na\u2010AS) for 18 weeks. The concentration of DCA and Na\u2010DC was reduced to 0.3% from week 12. At week 20, animals were killed and the numbers of immunohistochemically\u2010demonstrated PAPG were determined. Values were significantly higher with Na\u2010C and Na\u2010CDC than with the corresponding parent acids, and in the Na\u2010C case PAPG development was greater than with MNNG alone. In addition, Na\u2010CDC itself induced the numbers of PAPG significantly. These results suggest that bile salts are possible intrinsic promoters of gastric carcinogenesis. They were without effect, however, on forestomach lesions. \u00a9 1992 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/tcm.1770120404","type":"journal-article","created":{"date-parts":[[2006,2,4]],"date-time":"2006-02-04T12:26:44Z","timestamp":1139056004000},"page":"179-186","source":"Crossref","is-referenced-by-count":2,"title":["Effects of various bile acids and their sodium salts on development of pepsinogen\u2010altered pyloric glands in rats"],"prefix":"10.1002","volume":"12","author":[{"given":"Yasunori","family":"Yoshida","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masae","family":"Tatematsu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katsumi","family":"Takaba","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yutaka","family":"Shichino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobuyuki","family":"Ito","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,9,9]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"312","article-title":"Enhancing effects of N\u2010ethyl\u2010N'\u2010nitro\u2010N\u2010nitrosoguanidine and sodium taurocholate on development of pepsinogen 1 decreased pyloric glands in rats initiated with N\u2010methyl\u2010N'\u2010nitro\u2010N\u2010nitrosoguanidine","volume":"78","author":"Tatematsu M","year":"1987","journal-title":"Jpn J Cancer Res (Gann)"},{"key":"e_1_2_1_3_2","first-page":"771","article-title":"Immunohistochemical demonstration of pyloric gland\u2010type cells with low\u2010pepsinogen isozyme 1 in preneoplastic and neoplastic tissues of rat stomachs treated with N\u2010methyl\u2010N'\u2010nitro\u2010N\u2010nitrosoguanidine","volume":"78","author":"Tatematsu M","year":"1987","journal-title":"JNCI"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/9.3.495"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/10.5.907"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3835(90)90022-P"},{"key":"e_1_2_1_7_2","first-page":"853","article-title":"Enhancing effect of bile and bile acid on stomach tumorigenesis induced by N\u2010methyl\u2010N'\u2010nitro\u2010N\u2010nitrosoguanidine in 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