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Based on this concept, we have developed the <jats:italic><jats:styled-content style=\"fixed-case\">O<\/jats:styled-content><\/jats:italic>\u2010silylative Passerini reaction and the borinic acid catalyzed \u03b1\u2010addition of isocyanides to aldehydes and water. In addition, we have designed and demonstrated the addition reaction of isocyanides to nitrones in the presence of <jats:styled-content style=\"fixed-case\">TMSCl<\/jats:styled-content> to afford the corresponding 1,2,3,4\u2010tetrahydroisoquinoline\u20101\u2010carboxyamides. Furthermore, a novel [5\u2009+\u20091] cycloaddition of isocyanide was explored with <jats:italic><jats:styled-content style=\"fixed-case\">C<\/jats:styled-content><\/jats:italic>,<jats:italic><jats:styled-content style=\"fixed-case\">N<\/jats:styled-content><\/jats:italic>\u2010cyclic <jats:italic><jats:styled-content style=\"fixed-case\">N<\/jats:styled-content><\/jats:italic>\u2032\u2010acyl azomethine imines as a \u201c1,5\u2010dipole\u201d via a strategy involving intramolecular trapping of the isocyanide.<\/jats:p>","DOI":"10.1002\/tcr.201300021","type":"journal-article","created":{"date-parts":[[2014,1,22]],"date-time":"2014-01-22T12:06:18Z","timestamp":1390392378000},"page":"101-116","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Carboxylic Acid Free Novel Isocyanide\u2010Based Reactions"],"prefix":"10.1002","volume":"14","author":[{"given":"Takahiro","family":"Soeta","sequence":"first","affiliation":[{"name":"Division of Material Sciences Graduate School of Natural Science and Technology Kanazawa University  Kakuma Kanazawa Ishikawa 920\u20101192 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yutaka","family":"Ukaji","sequence":"additional","affiliation":[{"name":"Division of Material Sciences Graduate School of Natural Science and Technology Kanazawa University  Kakuma Kanazawa Ishikawa 920\u20101192 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,1,22]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.5059\/yukigoseikyokaishi.68.1239"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/jlac.18591120307"},{"key":"e_1_2_8_4_1","first-page":"126","volume":"51","author":"Passerini M.","year":"1921","journal-title":"Gazz. 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