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Firstly, the activation of aldehydic C\u2212H bonds can be successfully effected with hypervalent iodine(III) reagents, thereby allowing the synthesis of various ketones with high efficiency. Secondly, the site\u2010selective oxidation of unactivated C(sp<jats:sup>3<\/jats:sup>)\u2212H bonds of hydrocarbon substrates was realized with designer hypervalent iodine(III) reagents. Thirdly, various perfluoroalkyl and \u03b1\u2010aminoalkyl radicals can be generated from sodium perfluoroalkanesulfinates and sodium \u03b1\u2010aminoalkanesulfinates, respectively, under the influence of hypervalent iodine(III) reagents. Finally, the efficient generation of difluoromethyl radical from hypervalent difluoroacetoxyliodine(III) reagent was realized by photolysis. These four different strategies are illustrated by using various selective radical approaches.<\/jats:p>","DOI":"10.1002\/tcr.202000132","type":"journal-article","created":{"date-parts":[[2020,11,20]],"date-time":"2020-11-20T01:30:31Z","timestamp":1605835831000},"page":"1342-1357","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Development of New Radical\u2010Mediated Selective Reactions Promoted by Hypervalent Iodine(III) Reagents"],"prefix":"10.1002","volume":"21","author":[{"given":"Akira","family":"Matsumoto","sequence":"first","affiliation":[{"name":"Graduate School of Pharmaceutical Sciences Kyoto University Sakyo  Kyoto 606-8501 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyo\u2010Jun","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Chemistry Kunsan National University  Gunsan 54150 Republic of 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