{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T23:48:59Z","timestamp":1759362539080,"version":"3.37.3"},"reference-count":69,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,12,17]],"date-time":"2020-12-17T00:00:00Z","timestamp":1608163200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004040","name":"KU Leuven","doi-asserted-by":"publisher","award":["C14\/19\/78"],"award-info":[{"award-number":["C14\/19\/78"]}],"id":[{"id":"10.13039\/501100004040","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Chemical Record"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The development of metal\u2010free syntheses toward 1,2,3\u2010triazoles has been a burgeoning research area throughout the past decade. Despite the numerous advances, the scarceness of methods for the preparation of 1,5\u2010disubstituted 1,2,3\u2010triazoles from readily available substrates remained a challenge that was addressed by our group in 2016. A metal\u2010free three\u2010component reaction, which we have dubbed the triazolization reaction, was established for the rapid synthesis of 1,5\u2010disubstituted, fully functionalized and <jats:italic>NH<\/jats:italic>\u20101,2,3\u2010triazoles. This novel approach stands out because it utilizes widely available starting materials, namely primary amines and enolizable ketones. Furthermore, the broad substrate scope is a major advantage, and was further expanded by the number of modified protocols that have been reported. Triazolization products have successfully found utility as intermediates in various synthetic transformations, and were the subject of a few interesting biological activity studies.<\/jats:p>","DOI":"10.1002\/tcr.202000151","type":"journal-article","created":{"date-parts":[[2020,12,18]],"date-time":"2020-12-18T07:32:41Z","timestamp":1608276761000},"page":"376-385","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Triazolization of Enolizable Ketones with Primary Amines: A General Strategy toward Multifunctional 1,2,3\u2010Triazoles"],"prefix":"10.1002","volume":"21","author":[{"given":"Rashmi","family":"Prakash","sequence":"first","affiliation":[{"name":"Molecular Design and Synthesis Department of Chemistry KU Leuven  Celestijnenlaan 200F 3001 Leuven Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8272-0292","authenticated-orcid":false,"given":"Tomas","family":"Opsomer","sequence":"additional","affiliation":[{"name":"Molecular Design and Synthesis Department of Chemistry KU Leuven  Celestijnenlaan 200F 3001 Leuven Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9597-0629","authenticated-orcid":false,"given":"Wim","family":"Dehaen","sequence":"additional","affiliation":[{"name":"Molecular Design and Synthesis Department of Chemistry KU Leuven  Celestijnenlaan 200F 3001 Leuven Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,12,17]]},"reference":[{"key":"e_1_2_8_1_1","doi-asserted-by":"publisher","DOI":"10.1039\/c003740k"},{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1039\/B613014N"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1039\/c1cc10685f"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1039\/C6SC01832G"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1039\/C9NJ06330G"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2017.06.017"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.accounts.7b00371"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2014.04.006"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1021\/ar200235m"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1080\/17460441.2019.1614910"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drudis.2017.05.014"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1021\/cr200409f"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201008142"},{"key":"e_1_2_8_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/ange.201008142"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.200806390"},{"key":"e_1_2_8_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/ange.200806390"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/med.20107"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/cmdc.201402233"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1021\/jo011148j"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/1521-3757(20020715)114:14<2708::AID-ANGE2708>3.0.CO;2-0"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1021\/cr0783479"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1039\/b904091a"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja054114s"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.6b00466"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0707090104"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja044996f"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s41061-016-0016-4"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1039\/C5CC02319J"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1039\/C5CC04114G"},{"key":"e_1_2_8_28_1","first-page":"99","volume-title":"Synthesis of Substituted 1,2,3-Triazoles through Organocatalysis.","author":"Anebouselvy K.","year":"2016"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1080\/00397911.2017.1303511"},{"key":"e_1_2_8_30_1","first-page":"29","volume":"49","author":"Jalani H. 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