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The interesting reactivities that this class of compounds possess have made them ideal building blocks to access high\u2010value organic molecules. Furthermore, the\n                    <jats:italic>gem<\/jats:italic>\n                    \u2010difunctionalized ketone moiety has featured in numerous bioactive molecules. For these reasons, a plethora of routes to access such significant molecules have been developed by research groups worldwide \u2013 this account looks at delineating the synthesis of\n                    <jats:italic>gem<\/jats:italic>\n                    \u2010difunctionalized ketones from carbonyl substrates, diazo compounds, sulfur ylides and alkynyl reactants.\n                  <\/jats:p>","DOI":"10.1002\/tcr.202000176","type":"journal-article","created":{"date-parts":[[2021,2,6]],"date-time":"2021-02-06T08:38:32Z","timestamp":1612600712000},"page":"2837-2854","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Synthetic Routes Towards the Synthesis of Geminal \u03b1\u2010Difunctionalized Ketones"],"prefix":"10.1002","volume":"21","author":[{"given":"David P.","family":"Day","sequence":"first","affiliation":[{"name":"Instituto de Qu\u00edmica de S\u00e3o Carlos Universidade de S\u00e3o Paulo  CEP 13560-970 S\u00e3o Carlos, SP Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge A. M.","family":"Vargas","sequence":"additional","affiliation":[{"name":"Instituto de Qu\u00edmica de S\u00e3o Carlos Universidade de S\u00e3o Paulo  CEP 13560-970 S\u00e3o Carlos, SP Brasil"},{"name":"Facultad de Ciencias B\u00e1sicas Universidad Santiago de Cali  Calle 5 # 62\u201300 Campus Pampalinda Santiago de Cali Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2203-1556","authenticated-orcid":false,"given":"Antonio C. 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