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In this review, we have summarized the most recent advances achieved (2018\u20132020) in the research area of ketoreductase (KRED)\u2010catalyzed asymmetric synthesis of chiral secondary alcohol intermediates to pharmaceuticals and bioactive molecules. In the first part, synthesis of chiral alcohols with one stereocenter through the bioreduction of four different ketone classes, namely acyclic aliphatic ketones, benzyl or phenylethyl ketones, cyclic aliphatic ketones, and aryl ketones, is discussed. In the second part, KRED\u2010catalyzed dynamic reductive kinetic resolution and reductive desymmetrization are presented for the synthesis of chiral alcohols with two contiguous stereocenters.<\/jats:p>","DOI":"10.1002\/tcr.202100062","type":"journal-article","created":{"date-parts":[[2021,4,9]],"date-time":"2021-04-09T09:06:38Z","timestamp":1617959198000},"page":"1611-1630","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":78,"title":["Application of Ketoreductase in Asymmetric Synthesis of Pharmaceuticals and Bioactive Molecules: An Update (2018\u20132020)"],"prefix":"10.1002","volume":"21","author":[{"given":"Zhining","family":"Li","sequence":"first","affiliation":[{"name":"Department of Chemistry Engineering Center of Catalysis and Synthesis for Chiral Molecules Fudan University Shanghai Engineering Research Center of Industrial Asymmetric Catalysis of Chiral Drugs  220 Handan Road Shanghai 200433 P. R. 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