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Thus, the realization of anti\u2010Markovnikov (AM) selectivity in these reactions is challenging. This account focuses on our recent development of Pd\u2010catalyzed AM oxidation of terminal alkenes (mainly styrenes and aliphatic alkenes), that is, oxidative acetalization (oxidation to terminal acetals) and Wacker\u2010type oxidation (oxidation to aldehydes). The key factors that enhance the yield and AM selectivity of the products found in our studies are: 1) the steric bulkiness of the oxygen nucleophiles that attack on the coordinated alkenes, 2) the electron\u2010deficient cyclic alkenes as additives that withdraw electrons from Pd, 3) the slow addition of substrates in the case of the aliphatic alkenes, which suppresses the isomerization of the terminal alkenes into internal alkenes, and 4) the halogen directing groups in the case of aliphatic alkenes.<\/jats:p>","DOI":"10.1002\/tcr.202100090","type":"journal-article","created":{"date-parts":[[2021,5,22]],"date-time":"2021-05-22T06:54:57Z","timestamp":1621666497000},"page":"3458-3469","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Realization of Anti\u2010Markovnikov Selectivity in Pd\u2010Catalyzed Oxidative Acetalization and Wacker\u2010Type Oxidation of Terminal Alkenes"],"prefix":"10.1002","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0484-1299","authenticated-orcid":false,"given":"Yasuyuki","family":"Ura","sequence":"first","affiliation":[{"name":"Department of Chemistry, Biology, and Environmental Science, Faculty of Science Nara Women's University  Kitauoyanishi-machi Nara 630-8506 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,5,21]]},"reference":[{"key":"e_1_2_6_1_1","doi-asserted-by":"publisher","DOI":"10.1002\/ange.19590710503"},{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.196200801"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja00503a029"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-1984-30848"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/0471473804.ch23"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.2174\/1385272033372851"},{"key":"e_1_2_6_7_1","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1002\/9783527619405.ch5h","volume-title":"Transition Metals for Organic Synthesis, Vol. 2","author":"Hintermann L.","year":"2004"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1021\/cr050523v"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1021\/ic061858d"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.200902194"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/ange.200902194"},{"key":"e_1_2_6_11_1","doi-asserted-by":"crossref","unstructured":"B.\u2005W. 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