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Among the multi\u2010component reactions, the three\u2010component processes have been developed into effective organic procedures. This personal account reviews our and other group's studies on the development of three\u2010component coupling reaction for the rapid construction of two new chemical bonds simultaneously via benzylpalladium intermediates. Catalyst\u2010switched three\u2010component reactions of benzyl halides, activated olefins, and allyltributylstannane were successfully conducted to produce the corresponding benzylallylation products. Activation and conversion of carbon monoxide and carbon dioxide via \u03c0\u2010benzylpalladium intermediates provide access to a wide range of unsaturated ketones and esters with excellent functional group tolerance. Meanwhile, other methods to produce benzylpalladium intermediates, including Heck insertion of alkenes into arylpalladium complexes, the oxidative addition of benzyl carbonate to palladium complexes and palladium\u2212carbene migratory insertion, were also highlighted.<\/jats:p>","DOI":"10.1002\/tcr.202100112","type":"journal-article","created":{"date-parts":[[2021,5,24]],"date-time":"2021-05-24T12:33:55Z","timestamp":1621859635000},"page":"3559-3572","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Palladium\u2010Catalyzed Three\u2010Component Coupling Reaction via Benzylpalladium Intermediate"],"prefix":"10.1002","volume":"21","author":[{"given":"Sheng","family":"Zhang","sequence":"first","affiliation":[{"name":"State Key Laboratory of Fine Chemicals Dalian University of Technology  Dalian 116023 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