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This has inspired the synthetic community to design and develop mimics of natural products either to answer important questions in biology or to explore their therapeutic potentials. Glycosides present themselves abundantly in nature, right from the cell surface receptors to natural products of any origin. The\n                    <jats:italic>O<\/jats:italic>\n                    \u2010Glycosides are hydrolytically less stable compared to\n                    <jats:italic>C<\/jats:italic>\n                    \u2010glycosides and this feature has presented a great opportunity for drug discovery. The discovery of Dapagliflozin, an SGLT inhibitor and\n                    <jats:italic>C<\/jats:italic>\n                    \u2010glucoside, for the treatment of diabetes is one such example. Aryl acyl\u2010anion chemistry has been explored for the synthesis of 2\u2010deoxy\u2010C\u2010aryl furanoside\/pyranoside\/septanosides. Besides success, the studies have provided valuable insight into the natural propensities of the architectural framework for the cascade to furan derivatives. The aryl acyl\u2010anion chemistry has also enabled the synthesis of biologically active diaryl heptanoids. Inspired from sucesss of Dapagliflozin, new analogues have been synthesized with pyridine and isocoumarin heterocycle as the proximal ring.\n                    <jats:italic>C<\/jats:italic>\n                    \u2010glucosides of isoliquiritigenin have been synthesized for the first time and evaluated as an efficient aldose reductase inhibitor. The synthesis and evaluation of acyl\u2010\n                    <jats:italic>C<\/jats:italic>\n                    \u2010\u03b2\u2010D\u2010glucosides and benzyl\u2010\n                    <jats:italic>C<\/jats:italic>\n                    \u2010\u03b2\u2010D\u2010glucoside as glucose\u2010uptake promoters has revealed promise in small molecules. The concept of building blocks has been used to obtain natural oxylipins, D\u2010\n                    <jats:italic>xylo<\/jats:italic>\n                    and L\u2010\n                    <jats:italic>xylo<\/jats:italic>\n                    \u2010configured alkane tetrols and novel lipophilic ketones with\n                    <jats:italic>erythro<\/jats:italic>\n                    \/\n                    <jats:italic>threo<\/jats:italic>\n                    configured trihydroxy polar head\u2010group as possible anti\u2010mycobacterial agents.\n                  <\/jats:p>","DOI":"10.1002\/tcr.202100216","type":"journal-article","created":{"date-parts":[[2021,10,29]],"date-time":"2021-10-29T09:32:05Z","timestamp":1635499925000},"page":"3131-3177","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Natural Products &amp; Bioactivity Inspired Synthetic Pursuits Interfacing with Carbohydrates: Ongoing Journey with\n                    <i>C<\/i>\n                    \u2010Glycosides"],"prefix":"10.1002","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7330-7404","authenticated-orcid":false,"given":"Indrapal","family":"Singh Aidhen","sequence":"first","affiliation":[{"name":"Department of Chemistry Indian Institute of Technology Madras  Chennai 600036 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naveenkumar","family":"Thoti","sequence":"additional","affiliation":[{"name":"Department of Chemistry Indian Institute of Technology Madras  Chennai 600036 India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,10,29]]},"reference":[{"key":"e_1_2_5_1_1","unstructured":"The corresponding author Indrapal Singh Aidhen as an Alexander von Humboldt Fellow remains indebted to the Alexander Humboldt Foundation for the fellowship. 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