{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T18:17:30Z","timestamp":1791569850272,"version":"4.3.4"},"reference-count":122,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,2,10]],"date-time":"2023-02-10T00:00:00Z","timestamp":1675987200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Chemical Record"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    During last two decades, there has been an enormous growth in the discovery of innovative active inorganic anticancer complexes (exerting remarkable cytotoxicity at sub micro\u2010molar levels) derived from myriad ligand scaffolds, mainly acting on cancerous\n                    <jats:italic>vs<\/jats:italic>\n                    healthy cells by either halting or inhibiting their uncontrolled growth. The phenomenal success of cisplatin to treat numerous forms of solid malignancies has placed metal\u2010based drugs to the forefront of treatment strategies against cancers. More than 10,000 platinum anticancer complexes have been developed during the past 40\u2005years, but only five drugs have been approved for usage in humans while ten more complexes are currently undergoing clinical trials. Most of the compounds have failed either at R&amp;D stages or in preclinical trails. This has led to extensive investigations by researchers of medicinal chemistry, including our group to design and prepare tailored 3d\u2010metallo\u2010drugs and organotin(IV) compounds from some naturally occurring bioactive compounds, such as amino\u2010acids, peptides, chromone derivatives and NSAID's etc. that were used either alone or in cocktail combination, capable of specifically targeting DNA, lnc RNAs and proteins. Furthermore, 3d\u2010metal ions such as copper, cobalt and zinc etc. incorporated in these ligand framework are biocompatible and induce a unique multi\u2010modal mechanism of cytotoxic action involving angiogenesis, ROS\u2010induced DNA damage, apoptosis by p53 mitochondrial genes and caspases etc. The results observed a positive correlation between the binding affinity of complexes with DNA (as quantified by intrinsic binding constant values) and their cytotoxic behavior. Complexes with high DNA binding propensity were typically lethal against a diverse panel of malignant cell types compared to normal cells.\n                  <\/jats:p>","DOI":"10.1002\/tcr.202200247","type":"journal-article","created":{"date-parts":[[2023,2,10]],"date-time":"2023-02-10T07:11:40Z","timestamp":1676013100000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":45,"title":["Progress of Metal\u2010Based Anticancer Chemotherapeutic Agents in Last two Decades and their Comprehensive Biological (DNA\/RNA Binding, Cleavage and Cytotoxicity Activity) Studies"],"prefix":"10.1002","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4677-2682","authenticated-orcid":false,"given":"Farukh","family":"Arjmand","sequence":"first","affiliation":[{"name":"Department of Chemistry Aligarh Muslim University  Aligarh, U.P. India- 202002"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9407-1891","authenticated-orcid":false,"given":"Huzaifa","family":"Yasir Khan","sequence":"additional","affiliation":[{"name":"Department of Chemistry Aligarh Muslim University  Aligarh, U.P. India- 202002"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5301-898X","authenticated-orcid":false,"given":"Sartaj","family":"Tabassum","sequence":"additional","affiliation":[{"name":"Department of Chemistry Aligarh Muslim University  Aligarh, U.P. India- 202002"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,2,10]]},"reference":[{"key":"e_1_2_5_1_1","unstructured":"\u00a0"},{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1021\/cr400460s"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1521-3773(19990601)38:11<1512::AID-ANIE1512>3.0.CO;2-Y"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drudis.2009.09.003"},{"key":"e_1_2_5_5_1","unstructured":"\u00a0"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/222385a0"},{"key":"e_1_2_5_7_2","first-page":"589","volume":"59","author":"Rosenberg B.","year":"1975","journal-title":"Cancer Chemother. Rep."},{"key":"e_1_2_5_8_1","first-page":"101","volume-title":"Advances in Antimicrobial and Antineoplastic Chemotherapy, Vol. 2","author":"Rosenberg B.","year":"1972"},{"key":"e_1_2_5_9_1","unstructured":"\u00a0"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrc2167"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2014.07.025"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2014.08.002"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd1691"},{"key":"e_1_2_5_14_1","unstructured":"\u00a0"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-199346030-00003"},{"key":"e_1_2_5_16_2","first-page":"637","volume":"71","author":"Kidani Y.","year":"1980","journal-title":"Jpn. J. Cancer Res."},{"key":"e_1_2_5_17_1","unstructured":"\u00a0"},{"key":"e_1_2_5_18_2","doi-asserted-by":"crossref","unstructured":"I.\u2005A. Riddell J. Lippard Cisplatin and Oxaliplatin: Our Current Understanding of their actions. De Gruyter: Berlin2018 18 1\u201342;","DOI":"10.1515\/9783110470734-001"},{"key":"e_1_2_5_19_2","first-page":"230","volume":"28","author":"Zhang P.","year":"2006","journal-title":"Chin. J. Oncol."},{"key":"e_1_2_5_20_1","unstructured":"\u00a0"},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2016.01.001"},{"key":"e_1_2_5_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2019.102925"},{"key":"e_1_2_5_23_1","unstructured":"\u00a0"},{"key":"e_1_2_5_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinorgbio.2017.06.002"},{"key":"e_1_2_5_25_2","volume":"373","author":"Johnstone T. C.","year":"2015","journal-title":"Philos. Trans. R. Soc. London"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbpa.2007.11.013"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1039\/b514859f"},{"key":"e_1_2_5_28_1","doi-asserted-by":"crossref","unstructured":"C. Hartinger Ligand Design in Medicinal Inorganic Chemistry. Edited by Tim Storr. Angew. Chemie Int. Ed.2015 54 2324.","DOI":"10.1002\/anie.201412260"},{"key":"e_1_2_5_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41570-018-0018-6"},{"key":"e_1_2_5_30_1","doi-asserted-by":"publisher","DOI":"10.1039\/C4DT02700K"},{"key":"e_1_2_5_31_1","unstructured":"\u00a0"},{"key":"e_1_2_5_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinorgbio.2021.111624"},{"key":"e_1_2_5_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2013.02.023"},{"key":"e_1_2_5_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/0010-8545(90)85013-I"},{"key":"e_1_2_5_35_1","doi-asserted-by":"publisher","DOI":"10.1039\/C8CS00157J"},{"key":"e_1_2_5_36_1","unstructured":"\u00a0"},{"key":"e_1_2_5_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2019.02.015"},{"key":"e_1_2_5_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinorgbio.2016.04.021"},{"key":"e_1_2_5_39_1","unstructured":"\u00a0"},{"key":"e_1_2_5_40_2","doi-asserted-by":"publisher","DOI":"10.3390\/cancers11111652"},{"key":"e_1_2_5_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.gpb.2015.09.006"},{"key":"e_1_2_5_42_1","doi-asserted-by":"publisher","DOI":"10.1021\/cr0681546"},{"key":"e_1_2_5_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinorgbio.2016.04.021"},{"key":"e_1_2_5_44_1","doi-asserted-by":"publisher","DOI":"10.1021\/ar200098t"},{"key":"e_1_2_5_45_1","doi-asserted-by":"crossref","unstructured":"U. Meierhenrich\u2005in\u2005Amino\u2005acids the asymmetry of life: caught in the act of formation Springer Science & Business Media 2008.","DOI":"10.1007\/978-3-540-76886-9"},{"key":"e_1_2_5_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2003.07.013"},{"key":"e_1_2_5_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2003.07.020"},{"key":"e_1_2_5_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2012.04.046"},{"key":"e_1_2_5_49_1","doi-asserted-by":"publisher","DOI":"10.2174\/1386207023330200"},{"key":"e_1_2_5_50_1","doi-asserted-by":"publisher","DOI":"10.1038\/scientificamerican0190-108"},{"key":"e_1_2_5_51_1","doi-asserted-by":"publisher","DOI":"10.1021\/ic061753a"},{"key":"e_1_2_5_52_1","first-page":"1","volume":"3549","author":"Arjmand F.","year":"2010","journal-title":"Eur. J. Med. Chem."},{"key":"e_1_2_5_53_1","doi-asserted-by":"publisher","DOI":"10.1002\/chir.20907"},{"key":"e_1_2_5_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.saa.2011.09.006"},{"key":"e_1_2_5_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.saa.2010.06.009"},{"key":"e_1_2_5_56_1","doi-asserted-by":"publisher","DOI":"10.1039\/c2ra20660a"},{"key":"e_1_2_5_57_1","doi-asserted-by":"publisher","DOI":"10.1039\/C4MT00035H"},{"key":"e_1_2_5_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jorganchem.2016.09.015"},{"key":"e_1_2_5_59_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsomega.9b00131"},{"key":"e_1_2_5_60_1","doi-asserted-by":"publisher","DOI":"10.1039\/D0DT01527J"},{"key":"e_1_2_5_61_1","doi-asserted-by":"publisher","DOI":"10.1039\/D0DT02657C"},{"key":"e_1_2_5_62_1","doi-asserted-by":"publisher","DOI":"10.1093\/mtomcs\/mfab064"},{"key":"e_1_2_5_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ica.2012.03.019"},{"key":"e_1_2_5_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jphotobiol.2012.12.009"},{"key":"e_1_2_5_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.saa.2013.01.059"},{"key":"e_1_2_5_66_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm501026z"},{"key":"e_1_2_5_67_1","doi-asserted-by":"publisher","DOI":"10.1002\/cmdc.200600050"},{"key":"e_1_2_5_68_1","first-page":"185","volume":"9","author":"Marzano C.","year":"2009","journal-title":"Med. Chem."},{"key":"e_1_2_5_69_1","doi-asserted-by":"publisher","DOI":"10.1021\/cr400135x"},{"key":"e_1_2_5_70_1","unstructured":"\u00a0"},{"key":"e_1_2_5_71_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2008.07.018"},{"key":"e_1_2_5_72_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2407-14-527"},{"key":"e_1_2_5_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejps.2021.106092"},{"key":"e_1_2_5_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drudis.2021.01.015"},{"key":"e_1_2_5_75_1","doi-asserted-by":"publisher","DOI":"10.3390\/inorganics9020009"},{"key":"e_1_2_5_76_1","doi-asserted-by":"publisher","DOI":"10.1002\/chir.22081"},{"key":"e_1_2_5_77_1","doi-asserted-by":"publisher","DOI":"10.1039\/C5DT00770D"},{"key":"e_1_2_5_78_1","doi-asserted-by":"publisher","DOI":"10.1039\/C8RA06722H"},{"key":"e_1_2_5_79_1","doi-asserted-by":"publisher","DOI":"10.1007\/PL00012514"},{"key":"e_1_2_5_80_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00894-006-0154-7"},{"key":"e_1_2_5_81_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.5b00484"},{"key":"e_1_2_5_82_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2020.104327"},{"key":"e_1_2_5_83_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.poly.2021.115638"},{"key":"e_1_2_5_84_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ica.2022.120967"},{"key":"e_1_2_5_85_1","doi-asserted-by":"publisher","DOI":"10.1002\/slct.202102537"},{"key":"e_1_2_5_86_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejic.201501480"},{"key":"e_1_2_5_87_1","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-198427030-00004"},{"key":"e_1_2_5_88_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpg.2009.11.005"},{"key":"e_1_2_5_89_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-8049(99)00333-0"},{"key":"e_1_2_5_90_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0891-5849(02)01301-1"},{"key":"e_1_2_5_91_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V93.7.2386"},{"key":"e_1_2_5_92_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.20639"},{"key":"e_1_2_5_93_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arabjc.2010.12.006"},{"key":"e_1_2_5_94_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0010-8545(02)00086-3"},{"key":"e_1_2_5_95_1","doi-asserted-by":"publisher","DOI":"10.1039\/C9RA07464C"},{"key":"e_1_2_5_96_1","doi-asserted-by":"publisher","DOI":"10.1002\/slct.201802698"},{"key":"e_1_2_5_97_1","doi-asserted-by":"publisher","DOI":"10.1021\/cr980420v"},{"key":"e_1_2_5_98_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2021.214316"},{"key":"e_1_2_5_99_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2014.04.080"},{"key":"e_1_2_5_100_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ica.2014.05.015"},{"key":"e_1_2_5_101_1","doi-asserted-by":"publisher","DOI":"10.1039\/C7NJ03602G"},{"key":"e_1_2_5_102_1","doi-asserted-by":"publisher","DOI":"10.1039\/B307853C"},{"key":"e_1_2_5_103_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2007.03.022"},{"key":"e_1_2_5_104_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2006.07.015"},{"key":"e_1_2_5_105_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm060712l"},{"key":"e_1_2_5_106_1","doi-asserted-by":"publisher","DOI":"10.1080\/00958970801930047"},{"key":"e_1_2_5_107_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arabjc.2010.05.001"},{"key":"e_1_2_5_108_1","doi-asserted-by":"publisher","DOI":"10.1002\/aoc.5687"},{"key":"e_1_2_5_109_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2012.08.019"},{"key":"e_1_2_5_110_1","doi-asserted-by":"publisher","DOI":"10.1039\/C2DT32155F"},{"key":"e_1_2_5_111_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsomega.0c01206"},{"key":"e_1_2_5_112_1","doi-asserted-by":"publisher","DOI":"10.1002\/hc.520030422"},{"key":"e_1_2_5_113_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jorganchem.2005.12.033"},{"key":"e_1_2_5_114_1","doi-asserted-by":"publisher","DOI":"10.1039\/c2mt00137c"},{"key":"e_1_2_5_115_1","doi-asserted-by":"publisher","DOI":"10.1039\/C4RA13718C"},{"key":"e_1_2_5_116_1","doi-asserted-by":"publisher","DOI":"10.1021\/om301223k"},{"key":"e_1_2_5_117_1","doi-asserted-by":"publisher","DOI":"10.1002\/hlca.200590177"},{"key":"e_1_2_5_118_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jorganchem.2007.07.044"},{"key":"e_1_2_5_119_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jphotobiol.2011.08.001"},{"key":"e_1_2_5_120_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2012.01.005"},{"key":"e_1_2_5_121_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2012.09.051"},{"key":"e_1_2_5_122_1","doi-asserted-by":"publisher","DOI":"10.1039\/c3dt50646k"}],"container-title":["The Chemical Record"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/tcr.202200247","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/tcr.202200247","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/tcr.202200247","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,22]],"date-time":"2023-08-22T10:52:41Z","timestamp":1692701561000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/tcr.202200247"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2,10]]},"references-count":122,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2023,3]]}},"alternative-id":["10.1002\/tcr.202200247"],"URL":"https:\/\/doi.org\/10.1002\/tcr.202200247","archive":["Portico"],"relation":{},"ISSN":["1527-8999","1528-0691"],"issn-type":[{"value":"1527-8999","type":"print"},{"value":"1528-0691","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,2,10]]},"assertion":[{"value":"2022-11-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-02-10","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e202200247"}}