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Recently, 2D MXene has served as a ideal platform for the design and development of electrocatalysts with high activity, selectivity, and stability. This review article provides a detailed description of the structural engineering of MXene\u2010based electrocatalysts and summarizes the uses of 2D MXene in hydrogen evolution reactions, nitrogen reduction reactions, oxygen evolution reactions, oxygen reduction reactions, and methanol\/ethanol oxidation. Then, key issues and prospects for 2D MXene as a next\u2010generation platform in fundamental research and real\u2010world electrocatalysis applications are discussed. Emphasis will be given to material design and enhancement techniques. 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