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It is an important precursor to access of some blockbuster antiviral drugs such as Carbovir or Abacavir as well as other carbocyclic neuraminidase inhibitors as antiviral agents. The ring C=C bond of the Vince lactam allows versatile chemical manipulations to create not only functionalized \u03b3\u2010lactams, but also \u03b3\u2010amino acid derivatives with a cyclopentane framework. The aim of the current account is to summarize the chemistry of Vince lactam, its synthetic utility and application in organic and medicinal chemistry over the last decade.<\/jats:p>","DOI":"10.1002\/tcr.202400070","type":"journal-article","created":{"date-parts":[[2024,7,15]],"date-time":"2024-07-15T21:23:30Z","timestamp":1721078610000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Application of 2\u2010Azabicyclo[2.2.1]Hept\u20105\u2010En\u20103\u2010One (Vince Lactam) in Synthetic Organic and Medicinal Chemistry"],"prefix":"10.1002","volume":"24","author":[{"given":"Melinda","family":"Nonn","sequence":"first","affiliation":[{"name":"MTA TTK Lend\u00fclet Artificial Transporter Research Group Institute of Materials and Environmental Chemistry HUN-REN Research Center for Natural Sciences  H-1117 Budapest Magyar tud\u00f3sok krt. 2 Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Santos","family":"Fustero","sequence":"additional","affiliation":[{"name":"Department of Organic Chemistry University of Valencia Pharmacy Faculty  Val\u00e8ncia 46100-Burjassot Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2346-9816","authenticated-orcid":false,"given":"Lor\u00e1nd","family":"Kiss","sequence":"additional","affiliation":[{"name":"Institute of Organic Chemistry Stereochemistry Research Group HUN-REN Research Center for Natural Sciences  H-1117 Budapest Magyar tud\u00f3sok krt. 2 Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,7,15]]},"reference":[{"key":"e_1_2_6_1_1","unstructured":"\u00a0"},{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1021\/cr2004822"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tetasy.2016.08.011"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tet.2014.11.043"},{"key":"e_1_2_6_5_1","unstructured":"\u00a0"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja00747a027"},{"key":"e_1_2_6_7_2","first-page":"2043","volume":"85","author":"Durst T.","year":"1970","journal-title":"J. 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