{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T13:20:18Z","timestamp":1792761618498,"version":"4.5.0"},"reference-count":41,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,9,6]],"date-time":"2025-09-06T00:00:00Z","timestamp":1757116800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Chemical Record"],"published-print":{"date-parts":[[2025,11,27]]},"abstract":"<jats:p>\n                    An \u03b1\u2010aryl\u2010substituted enantioenriched ketone is a valuable building block for the production of both natural and medicinal compounds. Research into their asymmetric synthesis can be challenging yet rewarding because of the need to control regio\u2010, chemo\u2010, and enantioselectivity carefully. A wide range of catalytic strategies has been developed during the past three decades to gain access to these favored motifs. This review provides a comprehensive overview of catalytic approaches for the asymmetric synthesis of chiral \u03b1\u2010aryl ketones, classifying the methods according to the type of catalyst employed, including chiral Br\u00f8nsted acid and Lewis acid\u2010assisted Br\u00f8nsted acid catalysis, transition metal catalysis (palladium, nickel, copper, and cobalt systems), and\n                    <jats:italic>N<\/jats:italic>\n                    \u2010heterocyclic carbene catalysis. The mechanistic diversity of these methods, encompassing enolate arylation, acylation, hydroacylation, protonation, rearrangement, and direct C\uf8ffH functionalization, has facilitated the synthesis of various chiral \u03b1\u2010aryl ketones under consistently milder and more sustainable circumstances.\n                  <\/jats:p>","DOI":"10.1002\/tcr.202500145","type":"journal-article","created":{"date-parts":[[2025,9,6]],"date-time":"2025-09-06T10:25:33Z","timestamp":1757154333000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Advances in the Catalytic Asymmetric Synthesis of Chiral \u03b1\u2010Aryl Ketones"],"prefix":"10.1002","volume":"25","author":[{"given":"Jisna","family":"Jose","sequence":"first","affiliation":[{"name":"Department of Chemistry St. Thomas College Palai  Arunapuram P.O. Kottayam Kerala 686574 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5650-5241","authenticated-orcid":false,"given":"Thomas V.","family":"Mathew","sequence":"additional","affiliation":[{"name":"Department of Chemistry St. Thomas College Palai  Arunapuram P.O. Kottayam Kerala 686574 India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,9,6]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.0c00153"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1021\/ol401752u"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1021\/np030236r"},{"key":"e_1_2_7_5_1","first-page":"481","volume":"533","author":"Zanos P.","year":"2016","journal-title":"Nat. 2016 5337604"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/cns.12099"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.200903424"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.1c00496"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsorginorgau.1c00025"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1055\/a-1560-5245"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1021\/acscatal.9b04480"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tetasy.2004.09.035"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja00103a052"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja8041542"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1039\/c0cc02492a"},{"key":"e_1_2_7_16_1","first-page":"3758","volume":"116","author":"Ishihara K.","year":"1994","journal-title":"Angew. 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